Complement C5 from Human Plasma, CAS No.80295-53-0

CAS: 80295-53-0 Cat. No.: np001101 Molecular Weight: 190,000 Da (2 chains)

GRADE & PURITY BioReagent, Native, PBS Only, ≥95%(SDS-PAGE), Protein concentration: See COA

Accession #

P01031

Overview

Complement C5 is part of the terminal sequence in the complement pathway. In particular, it is cleaved into C5a and C5b which are responsible for chemotaxis, inflammation, and initiating the formation of the membrane attack complex (MAC). Drugs that inhibit complement C5 have been used in Paroxysmal nocturnal hemoglobinuria (PNH) patients to lessen thrombotic complications by lessening intravascular hemolysis.

Complement component C5 is processed by convertase enzymes in a cascade modulated in a unique way. The multi-subunit catalytic complex initially shows little activity against C5, but instead cleaves C3. A C3 cleavage product C3b covalently attaches to the complex and shifts its specificity to C5 by a factor of 1000.

Purity: >=95% by SDS-PAGE.

Reacts to C5 antisera on Western Blot

Not tested for biological activity.

Prepared from plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests. 

Specifications

Product Name

Complement C5 from Human Plasma, CAS No.80295-53-0

Synonyms

Complement component C5 | C5D | C5a | C5b | ECLZB | CPAMD4

Grade

BioReagent, Native, PBS Only

Specifications & Purity

BioReagent, Native, PBS Only, ≥95%(SDS-PAGE), Protein concentration: See COA

Biochemical and Physiological Mechanisms

Precursor of the C5a anaphylatoxin and complement C5b components of the complement pathways, which consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. Activated

Accession #

P01031

Predicted molecular weight

190 kDa

CAS

80295-53-0

Molecule Type

Protein

Storage and Shipping

Shape

Frozen liquid in PBS, pH 7.4

Concentration

Protein concentration: See COA

Storage

Store at -80°C,Avoid repeated freezing and thawing

Shipped In

Dry ice packs + Cold packs

Stability And Storage

Store at -80℃ long term (>1 year). Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.