Cortistatin 14 - ≥97%(HPLC) , CAS No.186901-48-4

CAS: 186901-48-4 Cat. No.: C118800 Molecular Weight: 1721.01 PubChem CID: 16133803

GRADE & PURITY ≥97%(HPLC)

Synonyms

Cortistatin 14 | PUBCHEM_16133803 | Cortistatin-14, >=97% (HPLC) | CST-14 | cortistatin | AKOS024457590 | DTXSID00583202 | HY-P1212 | Cortistatin 14, human, rat | CAS_186901-48-4 | Cortistatin-14 (trifluoroacetate salt) | Corticostatin-14 | BDBM85324 | co

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

Pro-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Ser-Ser-Cys-Lys [Disulfide bridge: 2–13]

Specifications

Synonyms

Cortistatin 14 | PUBCHEM_16133803 | Cortistatin-14, >=97% (HPLC) | CST-14 | cortistatin | AKOS024457590 | DTXSID00583202 | HY-P1212 | Cortistatin 14, human, rat | CAS_186901-48-4 | Cortistatin-14 (trifluoroacetate salt) | Corticostatin-14 | BDBM85324 | co

Specifications & Purity

≥97%(HPLC)

Biochemical and Physiological Mechanisms

Somatostatin-like neuropeptide with neuronal depressant and sleep modulating properties. Exogenous cortistatin impairs short-term memory processing.Endogenous neuropeptide, expressed in the cortex and hippocampus. Structural and functional similarities to

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥97%(HPLC)

Names and Identifiers

• Canonical Smiles: CC(C1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CCCCN)CC2=CNC3=CC=CC=C32)CC4=CC=CC=C4)CC5=CC=CC=C5)CC(=O)N)CCCCN)NC(=O)C6CCCN6)C(=O)NC(CCCCN)C(=O)O)CO)CO)CC7=CC=CC=C7)O
• IUPAC Name: (2S)-6-amino-2-[[(4R,7S,10S,13S,16S,19S,22S,25S,28S,31S,34S,37R)-19,34-bis(4-aminobutyl)-31-(2-amino-2-oxoethyl)-13,25,28-tribenzyl-16-[(1R)-1-hydroxyethyl]-7,10-bis(hydroxymethyl)-22-(1H-indol-3-ylmethyl)-6,9,12,15,18,21,24,27,30,33,36-undecaoxo-37-[[(2S)-pyrrolidine-2-carbonyl]amino]-1,2-dithia-5,8,11,14,17,20,23,26,29,32,35-undecazacyclooctatriacontane-4-carbonyl]amino]hexanoic acid
• InChIKey: DDRPLNQJNRBRNY-WYYADCIBSA-N
• INCHI: 1S/C81H113N19O19S2/c1-46(103)67-80(117)95-59(38-49-24-9-4-10-25-49)73(110)96-62(42-101)76(113)97-63(43-102)77(114)99-65(79(116)90-56(81(118)119)30-15-18-34-84)45-121-120-44-64(98-68(105)53-31-19-35-86-53)78(115)89-54(28-13-16-32-82)69(106)94-61(40-66(85)104)75(112)92-57(36-47-20-5-2-6-21-47)71(108)91-58(37-48-22-7-3-8-23-48)72(109)93-60(39-50-41-87-52-27-12-11-26-51(50)52)74(111)88-55(70(107)100-67)29-14-17-33-83/h2-12,20-27,41,46,53-65,67,86-87,101-103H,13-19,28-40,42-45,82-84H2,1H3,(H2,85,104)(H,88,111)(H,89,115)(H,90,116)(H,91,108)(H,92,112)(H,93,109)(H,94,106)(H,95,117)(H,96,110)(H,97,113)(H,98,105)(H,99,114)(H,100,107)(H,118,119)/t46-,53+,54+,55+,56+,57+,58+,59+,60+,61+,62+,63+,64+,65+,67+/m1/s1
• Isomeric SMILES: C[C@H]([C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CCCCN)CC2=CNC3=CC=CC=C32)CC4=CC=CC=C4)CC5=CC=CC=C5)CC(=O)N)CCCCN)NC(=O)[C@@H]6CCCN6)C(=O)N[C@@H](CCCCN)C(=O)O)CO)CO)CC7=CC=CC=C7)O
• WGK Germany: 3
• PubChem CID: 16133803
• Molecular Weight: 1721.01

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic Polymers
    • Class Polypeptides

• Kingdom: Organic compounds
• Superclass: Organic Polymers
• Class: Polypeptides
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Polypeptides
• Alternative Parents: Cyclic peptides Macrolactams N-acyl-L-alpha-amino acids Proline and derivatives Alpha amino acid amides 3-alkylindoles Medium-chain fatty acids Pyrrolidinecarboxamides Heterocyclic fatty acids Amino fatty acids Hydroxy fatty acids Substituted pyrroles Benzene and substituted derivatives Heteroaromatic compounds Primary carboxylic acid amides Organic disulfides Amino acids Lactams Secondary alcohols Secondary carboxylic acid amides Monocarboxylic acids and derivatives Azacyclic compounds Carboxylic acids Dialkylamines Organic oxides Hydrocarbon derivatives Carbonyl compounds Primary alcohols Monoalkylamines
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Polypeptide - Cyclic alpha peptide - Macrolactam - Proline or derivatives - N-acyl-alpha-amino acid - N-acyl-l-alpha-amino acid - N-acyl-alpha amino acid or derivatives - Alpha-amino acid amide - Alpha-amino acid or derivatives - 3-alkylindole - Indole - Indole or derivatives - Pyrrolidine carboxylic acid or derivatives - Pyrrolidine-2-carboxamide - Medium-chain fatty acid - Hydroxy fatty acid - Heterocyclic fatty acid - Amino fatty acid - Monocyclic benzene moiety - Fatty acyl - Fatty acid - Benzenoid - Substituted pyrrole - Pyrrole - Heteroaromatic compound - Pyrrolidine - Primary carboxylic acid amide - Carboxamide group - Amino acid - Lactam - Amino acid or derivatives - Organic disulfide - Secondary alcohol - Secondary carboxylic acid amide - Azacycle - Organoheterocyclic compound - Carboxylic acid derivative - Carboxylic acid - Secondary amine - Secondary aliphatic amine - Monocarboxylic acid or derivatives - Organic oxide - Amine - Organic oxygen compound - Organic nitrogen compound - Carbonyl group - Alcohol - Hydrocarbon derivative - Primary amine - Primary alcohol - Organooxygen compound - Organonitrogen compound - Primary aliphatic amine - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as polypeptides. These are peptides containing ten or more amino acid residues.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

MRGPRX2 Tchem Mas-related G-protein coupled receptor member X2 (67 Activities)

Discover Target: MRGPRX2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Molecular Weight: 1721.000 g/mol
• XLogP3: -2.700
• Hydrogen Bond Donor Count: 23
• Hydrogen Bond Acceptor Count: 25
• Rotatable Bond Count: 30
• Exact Mass: 1719.79 Da
• Monoisotopic Mass: 1719.79 Da
• Topological Polar Surface Area: 676.000 Ų
• Heavy Atom Count: 121
• Formal Charge: 0
• Complexity: 3400.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 15
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

References

1. Yuanyuan Ding, Tianyou Ma, Yonghui Zhang, Chenrui Zhao, Chao Wang, Zhao Wang.  (2023)  Rosmarinic acid ameliorates skin inflammation and pruritus in allergic contact dermatitis by inhibiting mast cell-mediated MRGPRX2/PLCγ1 signaling pathway.  INTERNATIONAL IMMUNOPHARMACOLOGY,      [PMID:36931000] [10.1016/j.intimp.2023.110003]

2. Yilei Guo, Dandan Sun, Yajing Zhang, Xiaoxiao Yu, Yulai Fang, Changjun Lv, Qin Zhang, Yanrong Zhu, Simiao Qiao, Yufeng Xia, Zhifeng Wei, Yue Dai.  (2022)  The neuropeptide cortistatin attenuates Th17 cell response through inhibition of glycolysis via GHSR1.  INTERNATIONAL IMMUNOPHARMACOLOGY,      [PMID:35598399] [10.1016/j.intimp.2022.108843]