10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 2 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
Costunolide Costunolide (NSC 106404), a natural sesquiterpene compound with multiple biological activities; inhibits FPTase with IC50 of 20 μM, also inhibits telomerase with IC50 of 65-90 μM.
In vitro
Costunolide inhibits the growth and telomerase activity of MCF-7 and MDA-MB-231 cells in a concentration- and time-dependent manner. Costunolide also inhibits the farnesylation process of human lamin-B by farnesyl–proteinttransferase (FPTase), in a dose dependent manner. Continuously treatment of Costunolide for 48 hours will significantly decrease proliferation of human tumor cells (A549, SK-OV-3, SK-MEL-2, XF498 and HCT-1) in a dose-dependent manner. Costunolide induces apoptosis by ROS-mediated mitochondrial permeability transition and cytochrome C release to the cytosol in HL-60 human leukemia cells. A recent study indicates that Costunolide shows significant antifungal activity, including Trichophyton mentagrophytes, T.simlii, T.rubrum, and so on.
In vivo
Costunolide inhibits angiogenic response by blocking the angiogenic factor signaling pathway. In a mouse corneal micropocket assay, Costunolide reduces VEGF-stimulated neovascularization in mice.
Cell Data
cell lines：SH-SY5Y-α7 cells
Concentrations：0-100 μM
Incubation Time：48 hours
Powder Purity:≥97%
| Isomeric SMILES | C/C/1=C\CC/C(=C/[C@@H]2[C@@H](CC1)C(=C)C(=O)O2)/C |
|---|---|
| WGK Germany | 3 |
| RTECS | LY4270000 |
| Molecular Weight | 232.32 |
| Reaxy-Rn | 22984848 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=22984848&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| Specific Rotation[α] | 118° (C=0.2,CHCl3) |
|---|---|
| Melt Point(°C) | 106°C(lit.) |
| 1. Zhu Xiaona, Bai Bin, Ge Xiangting, Zheng Bin, Xiao Zhongxiang, Tang Yue, Fang Letong, Tang Yelin, Dai Yuanrong, Zhang Bing, Zhang Yali. (2023) Costunolide attenuates LPS-induced inflammation and lung injury through inhibiting IKK/NF-κB signaling. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, [PMID:37688623] [10.1007/s00210-023-02705-0] |
| 2. Hu Yingying, Qian Rengcheng, He Yifeng, Gao Qiqi, Wang Xun, Lin Huilin, Lin Wei, Fang Yu, Zhu Jianghu, Wang Xingyun, Nan Yan, Lin Zhenlang. (2025) Inhibition of Neuroinflammation by Costunolide Attenuates Hypoxic-Ischemic Brain Damage via the PI3K/AKT Pathway in Neonatal Rats. MOLECULAR NEUROBIOLOGY, 63 (1): (39). [PMID:41236577] [10.1007/s12035-025-05372-9] |
