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Crolibulin (EPC2407) - Moligand™,≥98% , Tubulin inhibitor, CAS No.1000852-17-4, Tubulin inhibitor

CAS: 1000852-17-4 Cat. No.: C647301 Molecular Weight: 417.26 PubChem CID: 23649181
COA
Crolibulin - ≥98% CAS No(1000852-17-4) by Aladdin Scientific
AVAILABLE TO ORDER
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
Synonyms
(R)-2,7,8-triamino-4-(3-bromo-4,5-dimethoxyphenyl)-4H-chromene-3-carbonitrile | EPC2407 | EPC-2407 | Q252344 | D09882 | 1000852-17-4 | AT-20GF | JXONINOYTKKXQQ-CQSZACIVSA-N | BG0 | CROLIBULIN [WHO-DD] | UNII-9ENT43KY91 | Q27272449 | CROLIBULIN [INN] | EX-
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
★
 ·  off list, applied to all prices below.
Size
Status
Price
Qty
1mg
C647301-1mg
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.
$23.90
5mg
C647301-5mg
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.
$82.90
25mg
C647301-25mg
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.
$289.90
100mg
C647301-100mg
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.
$899.90
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SDS
Safety data
COA
Certificate
DS
Datasheet
SP
Spec sheet
Overview Specifications Product Properties Names and Identifiers Documentation Advanced Data Taxonomic Classification 3D Structure Associated Targets(Human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Solution Calculators Reviews
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Why this grade

Moligand™,≥98% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

Crolibulin (EPC2407) is a tubulin polymerization inhibitor, with potent apoptosis induction and cell growth inhibition. Crolibulin has anti-tumor activity. Crolibulin also has cardiovascular toxicity and neurotoxicity

Specifications

Synonyms
(R)-2, 7, 8-triamino-4-(3-bromo-4, 5-dimethoxyphenyl)-4H-chromene-3-carbonitrile | EPC2407 | EPC-2407 | Q252344 | D09882 | 1000852-17-4 | AT-20GF | JXONINOYTKKXQQ-CQSZACIVSA-N | BG0 | CROLIBULIN [WHO-DD] | UNII-9ENT43KY91 | Q27272449 | CROLIBULIN [INN] | EX-
Specifications & Purity
Moligand™, ≥98%
Biochemical and Physiological Mechanisms
Crolibulin (EPC2407) is a tubulin polymerization inhibitor, with potent apoptosis induction and cell growth inhibition. Crolibulin has anti-tumor activity. Crolibulin also has cardiovascular toxicity and neurotoxicity.
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Grade
Moligand™
Action Type
INHIBITOR
Mechanism of action
Tubulin inhibitor
Purity
≥98%
Product Properties
ALogP2.6
Names and Identifiers
Canonical SmilesCOC1=C(C(=CC(=C1)C2C3=C(C(=C(C=C3)N)N)OC(=C2C#N)N)Br)OC
IUPAC Name(4R)-2,7,8-triamino-4-(3-bromo-4,5-dimethoxyphenyl)-4H-chromene-3-carbonitrile
InChIKeyJXONINOYTKKXQQ-CQSZACIVSA-N
INCHI1S/C18H17BrN4O3/c1-24-13-6-8(5-11(19)17(13)25-2)14-9-3-4-12(21)15(22)16(9)26-18(23)10(14)7-20/h3-6,14H,21-23H2,1-2H3/t14-/m1/s1
Isomeric SMILES COC1=C(C(=CC(=C1)[C@@H]2C3=C(C(=C(C=C3)N)N)OC(=C2C#N)N)Br)OC
PubChem CID 23649181
Molecular Weight 417.26

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassPhenylpropanoids and polyketides
ClassNeoflavonoids
SubclassNot available
Intermediate Tree Nodes Not available
Direct ParentNeoflavonoids
Alternative Parents Dimethoxybenzenes  1-benzopyrans  Phenoxy compounds  Anisoles  Bromobenzenes  Alkyl aryl ethers  Aryl bromides  Ketene acetals  Oxacyclic compounds  Nitriles  Primary amines  Organobromides  Hydrocarbon derivatives  
Molecular FrameworkAromatic heteropolycyclic compounds
Substituents Neoflavonoid skeleton - Benzopyran - 1-benzopyran - O-dimethoxybenzene - Dimethoxybenzene - Anisole - Phenoxy compound - Phenol ether - Methoxybenzene - Alkyl aryl ether - Bromobenzene - Halobenzene - Benzenoid - Aryl bromide - Aryl halide - Monocyclic benzene moiety - Ketene acetal or derivatives - Organoheterocyclic compound - Oxacycle - Nitrile - Carbonitrile - Ether - Primary amine - Organic nitrogen compound - Cyanide - Amine - Organic oxygen compound - Organohalogen compound - Organobromide - Organonitrogen compound - Organooxygen compound - Hydrocarbon derivative - Aromatic heteropolycyclic compound
DescriptionThis compound belongs to the class of organic compounds known as neoflavonoids. These are compounds with a structure based on the 4-phenylchromene backbone.
External Descriptors Not available
3D Structure
Interactive Chemical Structure Model





Associated Targets(Human)
HT-29 (80576 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MKN-45 (2102 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
A549 (127892 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NCI-H460 (60772 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mechanisms of Action
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Chemical and Physical Properties
SolubilityDMSO : 125 mg/mL (299.57 mM; Need ultrasonic and warming)
Molecular Weight417.300 g/mol
XLogP32.600
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count3
Exact Mass416.048 Da
Monoisotopic Mass416.048 Da
Topological Polar Surface Area130.000 Ų
Heavy Atom Count26
Formal Charge0
Complexity606.000
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Solution Calculators
Reviews

Customer Reviews

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