CU-CPT9b - Moligand™,10mM in DMSO , CAS No.2162962-69-6

CAS: 2162962-69-6 Cat. No.: C655470 Molecular Weight: 251.28 PubChem CID: 135567366

GRADE & PURITY Moligand™, 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

CU-CPT9b is a specific TLR8 antagonist, with an IC 50 of 0.7 nM. CU-CPT9b shows high binding affinity towards TLR8 with a K d of 21 nM

In Vitro

CU-CPT9b is a specific TLR8 antagonist, with an IC 50 of 0.7±0.2 nM. ITC experiments have confirmed the strong binding of CU-CPT9b with a K d of 21 nM. It is shown that CU-CPT-9b binds to the inactive TLR8 dimer in a similar way to CU-CPT8m. CU-CPT9b utilizes hydrogen bonds with G351 and V520*, which are conserved among TLR8/antagonist structures. Additionally, CU-CPT9b forms water-mediated contacts with S516* and Q519*, which are not observed in TLR8/CU-CPT8m structure, suggesting that the enhanced potency of CU-CPT9b derives from the new interactions with these polar residues. The orientation of Y567* also changes to facilitate van der Waals interactions with CU-CPT9b as compared to TLR8/CU-CPT8m. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:TLR8 0.7 nM (IC 50 ) TLR8 21 nM (Kd)

Specifications

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

CU-CPT9b is a specific TLR8 antagonist, with an IC 50 of 0.7 nM. CU-CPT9b shows high binding affinity towards TLR8 with a K d of 21 nM.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Names and Identifiers

• Isomeric SMILES: CC1=C(C=CC(=C1)C2=C3C=CC(=CC3=NC=C2)O)O
• PubChem CID: 135567366
• Molecular Weight: 251.28