Cyclamic acid - Moligand™, 10mM in DMSO , Antagonist of TAS2R31;Antagonist of TAS2R43, CAS No.100-88-9, Antagonist of TAS2R31;Antagonist of TAS2R43

CAS: 100-88-9 Cat. No.: C408450 Molecular Weight: 179.24 Beilstein Registry Number: 2208885 EC Number: 202-898-1

GRADE & PURITY Moligand™, 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Cyclamic acid (NSC 220327) in the form of its sodium or calcium salt is one of the most widely used artificial sweeteners.
In vitro

Cyclamic acid in the form of its sodium or calcium salt is one of the most widely used artificial sweeteners in food and pharmaceuticals. Cyclamic acid is in use in more than 50 countries, especially in combination with other sweeteners, to eliminate aftertaste. However, the petition on Cyclamic acid, calcium and sodium cyclamate is being held in abeyance with the FDA in the USA (CFSAN - Office of Food Additive Safety, 2006).

In vivo

Cell Data

cell lines：BaF3.TPR-MET, H69 and H345 cells

Concentrations：

Incubation Time：

Powder Purity:

Specifications

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

A non-nutritive sweetener.Potent TAS 1 R 3 ligand. Binds to the transmembrane domain of TAS 1 R 3 . Action is unaffected by umami compounds. Putative carcinogenic agent in vivo. Orally active.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

ANTAGONIST

Mechanism of action

Antagonist of TAS2R31;Antagonist of TAS2R43

Names and Identifiers

• Isomeric SMILES: C1CCC(CC1)NS(=O)(=O)O
• WGK Germany: 2
• RTECS: GV6950000
• Alternate CAS: 100-88-9
• NSC Number: 220327
• MeSH Entry Terms: Calcium Cyclamate;Cyclamate;Cyclamate Calcium (2:1) Salt;Cyclamate, Calcium;Cyclamate, Calcium (2:1) Salt, Dihydrate;Cyclamate, Potassium;Cyclamate, Sodium;Cyclamate, Sodium Salt;Cyclamates;Cyclamic Acid;Potassium Cyclamate;Sodium Cyclamate
• Molecular Weight: 179.24
• Beilstein: 2208885
• Reaxy-Rn: 2208885
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2208885&ln=

Associated Targets(Human)

TAS2R43 Tchem Taste receptor type 2 member 43 (0 Activities)

Discover Target: TAS2R43

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TAS2R31 Tchem Taste receptor type 2 member 31 (0 Activities)

Discover Target: TAS2R31

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• Melt Point(°C): 169 °C(dec.)

References

1. Zirong Li, Jiancheng Luo, Jun Wang, Yuanyuan Yu, Qiang Wang, Ping Wang.  (2023)  An eco-friendly technique for shrink-resist finishing of dyed wool via combined use of hydrolase and cyclamate.  Journal of Cleaner Production,      [PMID:] [10.1016/j.jclepro.2023.139276]

2. Li’na Qiao, Sihua Qian, Yuhui Wang, Hengwei Lin.  (2018)  A colorimetric sensor array based on sulfuric acid assisted KMnO4 fading for the detection and identification of pesticides.  TALANTA,      [PMID:29426516] [10.1016/j.talanta.2018.01.029]