D-3 - ≥99% , CAS No.1967815-98-0

CAS: 1967815-98-0 Cat. No.: D651496 Formula: C₄₈H₄₇N₄O₁₀P Molecular Weight: 870.88

GRADE & PURITY ≥99%

Storage

Protected from light,Argon charged,Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

D-3, a phosphorpeptide, is an efficient, simple, and specific iPSC-eliminating agent.

In Vitro

D-3 prevents residual iPSC-induced teratoma formation in a mouse tumorigenicity assay. D-3 induces obvious loss of viability in 201B7 cells, with half maximal inhibitory concentration value of 192.3 ± 57.4 μM. D-3 induces an increase in the amount of activated elF2a, p38, and p44/42 MAPK, which\nare activated in response to cellular stress. D-3 also increases the number of Annexin-V and SYTOX-positive cells, indicating apoptotic and dead cells after D-3 treatment. D-3 has little influence on various non-iPSCs, including hepatocytes and neurons. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: Six human iPSCs lines and one human ESC line (khES1). Concentration: 400 μM. Incubation Time: 1-2 h. Result: Sufficient to induce a viability loss (>99% in all iPSC lines and >95% in khES1).

Form:Solid

Specifications

Specifications & Purity

≥99%

Biochemical and Physiological Mechanisms

D-3, a phosphorpeptide, is an efficient, simple, and specific iPSC-eliminating agent.

Storage

Protected from light,Argon charged,Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Purity

≥99%

Names and Identifiers

Molecular Weight

870.88