(D)-PPA 1 TFA - ≥99% , CAS No.D658817

CAS: D658817 Cat. No.: D658817 Molecular Weight: 1669.67

GRADE & PURITY ≥99%

Storage

Protected from light,Argon charged,Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

(D)-PPA 1 TFA is a hydrolysisresistant d-peptide antagonist. (D)-PPA 1 TFA serves as a potent PD-1/PD-L1 inhibitor. (D)-PPA 1 TFA binds to PD-1 with the affinity 0f 0.51 μM with in vitro and in vivo efficacy.

Appearance:Solid

In Vitro:(D)-PPA 1 TFA (0.2 mg/mL, 1.0 mg/mL) blocks the interaction between PD-1/PD-L1 at 1.0 mg/mL. (D)-PPA 1 TFA (3.125-100 μM; 24 h, 48 h) doesn’t kill tumor cells directly with no affect on CT26 cells growth. MCE has not independently confirmed the

In Vivo:(D)-PPA 1 TFA (2mg/kg; s.c. or i.p.; once daily for 7 d) inhibits CT26 tumor growth in vivo in mice. (D)-PPA 1 TFA (40 μg/mouse in 200 μL; i.v.; single dose) has the ability to target to tumor tissue in CT26-tumor-bearing mice. MCE has not inde

Biological Activity:(D)-PPA 1 TFA is a hydrolysisresistant d-peptide antagonist. (D)-PPA 1 TFA serves as a potent PD-1/PD-L1 inhibitor. (D)-PPA 1 TFA binds to PD-1 with the affinity 0f 0.51 μM with in vitro and in vivo efficacy.

Specifications

Specifications & Purity

≥99%

Storage

Protected from light, Argon charged, Desiccated, Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Purity

≥99%

Names and Identifiers

• Molecular Weight: 1669.67

Chemical and Physical Properties

• Solubility: H2O : 100 mg/mL (59.89 mM; Need ultrasonic)