Darovasertib (LXS-196) - Moligand™, 10mM in DMSO , Inhibitor of protein kinase C alpha;Inhibitor of protein kinase C theta, CAS No.1874276-76-2, Inhibitor of protein kinase C alpha;Inhibitor of protein kinase C theta

CAS: 1874276-76-2 Cat. No.: D408066 Molecular Weight: 472.47 EC Number: 975-583-6

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

IDE-196 | 2-​Pyrazinecarboxamide, 3-​amino-​N-​[3-​(4-​amino-​4-​methyl-​1-​piperidinyl)​-​2-​pyridinyl]​-​6-​[3-​(trifluoromethyl)​-​2-​pyridinyl]​-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Darovasertib (LXS-196) Darovasertib (LXS-196, IDE-196) is a selective inhibitor of protein kinase C (PKC) .
In vitro

In vivo

Cell Data

cell lines：MCF7 and T47D

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyms

IDE-196 | 2-​Pyrazinecarboxamide, 3-​amino-​N-​[3-​(4-​amino-​4-​methyl-​1-​piperidinyl)​-​2-​pyridinyl]​-​6-​[3-​(trifluoromethyl)​-​2-​pyridinyl]​-

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

Darovasertib (LXS-196, IDE-196) is a selective inhibitor of protein kinase C (PKC).

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

INHIBITOR

Mechanism of action

Inhibitor of protein kinase C alpha;Inhibitor of protein kinase C theta

Product Properties

• ALogP: 1.6
• hba_count: 5
• HBD Count: 3
• Rotatable Bond: 5

Names and Identifiers

• Isomeric SMILES: CC1(CCN(CC1)C2=C(N=CC=C2)NC(=O)C3=NC(=CN=C3N)C4=C(C=CC=N4)C(F)(F)F)N
• Molecular Weight: 472.47
• Reaxy-Rn: 29306963
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=29306963&ln=

Associated Targets(Human)

PRKCA Tchem Protein kinase C alpha type (2 Activities)

Discover Target: PRKCA

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PRKCQ Tchem Protein kinase C theta type (2 Activities)

Discover Target: PRKCQ

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• DMSO(mg / mL) Max Solubility: 22
• DMSO(mM) Max Solubility: 46.5638029927826
• Water(mg / mL) Max Solubility: ＜1