Decamethonium Bromide - 10mM in DMSO , Muscle-type nicotinic acetylcholine receptor partial agonist, CAS No.541-22-0, Muscle-type nicotinic acetylcholine receptor partial agonist

CAS: 541-22-0 Cat. No.: D408329 Molecular Weight: 418.30 EC Number: 208-772-2

GRADE & PURITY 10mM in DMSO

Synonyms

1,10-Decanediaminium, N1,N1,N1,N10,N10,N10-hexamethyl-, bromide (1:2)

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Decamethonium Bromide is a nicotinicAChRpartial agonist andneuromuscularblocking agent.
In vitro

Decamethonium (Syncurine) is a depolarizing muscle relaxant or neuromuscular blocking agent, and is used in anesthesia to induce paralysis. Decamethonium, which has a short action time, is similar to acetylcholine and acts as a partial agonist of the nicotinic acetylcholine receptor. In the motor endplate, it causes depolarization, preventing further effects to the normal release of acetylcholine from the presynaptic terminal, and therefore preventing the neural stimulus from affecting the muscle. In the process of binding, decamethonium actually activates (depolarizes) the motor endplate, but since the decamethonium itself is not degraded, the membrane remains depolarized and unresponsive to normal acetylcholine release.

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥100%

Specifications

Synonyms

1, 10-Decanediaminium, N1, N1, N1, N10, N10, N10-hexamethyl-, bromide (1:2)

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Decamethonium Bromide is a nicotinic AChR partial agonist and neuromuscular blocking agent.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

PARTIAL AGONIST

Mechanism of action

Muscle-type nicotinic acetylcholine receptor partial agonist

Names and Identifiers

• Isomeric SMILES: C[N+](C)(C)CCCCCCCCCC[N+](C)(C)C.[Br-].[Br-]
• WGK Germany: 3
• RTECS: BP5950000
• Molecular Weight: 418.30
• Reaxy-Rn: 3728288
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3728288&ln=

Associated Targets(Human)

ACHE Tclin Acetylcholinesterase (1 Activities)

Discover Target: ACHE

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• Solubility: Solubility (25°C) In vitro DMSO: 59 mg/mL (198.82 mM); Ethanol: 2 mg/mL (6.73 mM); Water: Insoluble