Defactinib - Moligand™, 10 mM in DMSO , CAS No.1073154-85-4

CAS: 1073154-85-4 Cat. No.: D1495477 Molecular Weight: 510.49 EC Number: 969-109-7

GRADE & PURITY Moligand™, 10 mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Defactinib (VS-6063; PF-04554878) is a novel FAK inhibitor with potential antiangiogenic and antineoplastic activities.

Specifications

Specifications & Purity

Moligand™, 10 mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

INHIBITOR

Product Properties

• ALogP: 1.4

Names and Identifiers

• Isomeric SMILES: CNC(=O)C1=CC=C(C=C1)NC2=NC=C(C(=N2)NCC3=NC=CN=C3N(C)S(=O)(=O)C)C(F)(F)F
• Alternate CAS: 1073154-85-4
• MeSH Entry Terms: defactinib;N-methyl-4-((4-(((3-methyl(methylsulfonyl)aminopyrazin-2-yl)methyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzamide;PF-04554878;VS-6063
• Molecular Weight: 510.49
• Reaxy-Rn: 18939458
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=18939458&ln=

References

1. Zhou Hao, Wang Wei, Cai Zedong, Jia Zhou-Yan, Li Yu-Yao, He Wei, Li Chen, Zhang Bang-Le.  (2024)  Injectable hybrid hydrogels enable enhanced combination chemotherapy and roused anti-tumor immunity in the synergistic treatment of pancreatic ductal adenocarcinoma.  JOURNAL OF NANOBIOTECHNOLOGY,  22  (1): (1-21).  [PMID:38902759] [10.1186/s12951-024-02646-7]