10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 5 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
Dexamethasone Acetate Dexamethasone (NSC 39471) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects.
In vitro
Dexamethasone inhibits COX-2 mRNA expression induced by IL-1 in human articular chondrocytes. Dexamethasone suppresses the cyclooxygenase-2 induction by tumor necrosis factor α (TNFα) with an IC50 of 1 nM in MC3T3-E1 cells. Dexamethasone binds to the glucocorticoid receptor and then to the glucocorticoid response element. Dexamethasone (10 μM) induces osteoblastic differentiation of rat bone marrow stromal cell cultures with elevated mRNA expression of alkaline phosphatase osteopontin, bone sialoprotein, and osteocalcin. Dexamethasone (5 μM) treatment decreases proliferation of adult hippocampal neural progenitor cells and SRE-driven gene expression.
In vivo
Dexamethasone (2 mg/kg) reduces the number of the BrdU-labeled hepatocytes by 80% in male Fischer F344 rats. Dexamethasone (2 mg/kg) pretreatment suppresses the expression of both TNF and IL-6 after partial hepatectomy and significantly reduces the proliferative response of the hepatocytes in male Fischer F344 rats. Dexamethasone also severely diminishes the induction and expansion of oval cells induced by the 2-acetylaminofluorene/partial hepatectomy (AAF/PH) protocol but does not have any effect on the proliferation of the bile duct cells stimulated by bile duct ligation. Dexamethasone (100 μg/kg) produces a significant decrease 59.2% of BrdU(+) hippocampal progenitor cells in Sprague–Dawley rats. Dexamethasone (100 μg/kg) decreases ERK activation in granule cell layer in Sprague–Dawley rats.
Cell Data
cell lines：
Concentrations：
Incubation Time：
Powder Purity:≥99%
| ALogP | 2.8 |
|---|
| Isomeric SMILES | C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)COC(=O)C)O)C)O)F)C |
|---|---|
| WGK Germany | 3 |
| RTECS | TU4050000 |
| Molecular Weight | 434.5 |
| Beilstein | 2342608 |
| Reaxy-Rn | 3508291 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3508291&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| Solubility | Solubility (25°C) In vitro DMSO: 50 mg/mL (79.42 mM); Water: Insoluble; Ethanol: Insoluble; |
|---|---|
| Refractive Index | 87 °C |
| Specific Rotation[α] | 87 ° (C=1, Dioxane) |
| Melt Point(°C) | 240°C |
| 1. Tao Wanjun, Xie Pei, Huang Chengyuan, Wang Ying, Huang Yu, Yin Zongning. (2023) Construction of PLGA nanoparticles modified with RWrNM and DLPC and their application in acute rhinosinusitis. Drug Delivery and Translational Research, [PMID:37966678] [10.1007/s13346-023-01450-4] |
| 2. Tingfeng Xu, Huijie Li, Yi Xia, Sheng Ding, Qingliang Yang, Gensheng Yang. (2023) Three-Dimensional-Printed Oral Films Based on LCD: Influence Factors of the Film Printability and Received Qualities. Pharmaceutics, 15 (3): (758). [PMID:36986619] [10.3390/pharmaceutics15030758] |
| 3. Guihua Gao, Sijia Li, Shuo Li, Yudan Wang, Pan Zhao, Xiangyu Zhang, Xiaohong Hou. (2017) A combination of computational−experimental study on metal-organic frameworks MIL-53(Al) as sorbent for simultaneous determination of estrogens and glucocorticoids in water and urine samples by dispersive micro-solid-phase extraction coupled to UPLC-MS/MS. TALANTA, [PMID:29332823] [10.1016/j.talanta.2017.12.071] |
| 4. Fukang Kong, Yannan Kou, Xu Zhang, Yue Tian, Bin Yang, Weihao Wang. (2025) Comparative Analysis of Metabolites of Wild and Cultivated Notopterygium incisum from Different Origins and Evaluation of Their Anti-Inflammatory Activity. MOLECULES, 30 (3): (468). [PMID:39942574] [10.3390/molecules30030468] |
| 5. Haolan Zhang, Hao Xiong, Wajiha Ahmed, Yuejun Yao, Shuqin Wang, Cunyi Fan, Changyou Gao. (2020) Reactive oxygen species-responsive and scavenging polyurethane nanoparticles for treatment of osteoarthritis in vivo. CHEMICAL ENGINEERING JOURNAL, [PMID:] [10.1016/j.cej.2020.128147] |
