Diamide - ≥97%(HPLC) , CAS No.10465-78-8

CAS: 10465-78-8 Cat. No.: D165635 Formula: C₆H₁₂N₄O₂ Molecular Weight: 172.19 Beilstein Registry Number: 1910410 EC Number: 233-951-7

GRADE & PURITY ≥97%(HPLC)

Synonyms

TMAD|(+/-)-Secobarbital|Azodicarboxylic acid bis-dimethylamide|1,N-dimethylformamide)|N,N',N'-Tetramethylazobisformamide|N,N,N',N'-Tetramethylazodicarboxamide|N,N,N',N'-Tetramethylazobisformamide|DIAMIDE|Tetramethyldiazenedicarboxamide|A 19315|(E)-1,1'-azobis(N,N-dimethylformamide)|Tetramethylazodicarboxamide|Formamide,1'-azobis[N,N-dimethyl-|Azodicarboxylic acid bis(dimethylamide); diamide|(E)-N,N,N',N'-tetramethyldiazene-1,2-dicarboxamide|Azodicarboxylic acid bis(dimethylamide)|N,N,N',N'-tetramethyldiazene-1,2-dicarboxamide|SDCCGSBI-0050383.P002|N,N,N',N'-Tetramethylazodicarboxamide(TMAD)|(3E)-3-(dimethylcarbamoylimino)-1,1-dimethylurea|(3E)-3-(dimethylcarbamoylimino)-1,1-dimethyl-urea|(E)-1-[(dimethylcarbamoyl)imino]-3,3-dimethylurea|N,N',N'-Tetramethylazoformamide|1,1'-Azobis(N,N-dimethylformamide)|Formamide, 1,1'-azobis(N,N-dimethyl-|N,N',N'-Tetramethylazodicarboxamide|(1E)-1-(dimethyl-carbamoylimino)-3,3-dimethyl-urea|1,1'-Azobis (N,N-dimethyl formamide)|3-(N,N-Dimethylcarbamoylimido)-1,1-dimethylurea|N1,N1,N2,N2-Tetramethyldiazene-1,2-dicarboxamide|Diazenedicarboxylic acid bis(N,N-dimethylamide)|N,N,N',N'-Tetramethylazoformamide

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Overview

Reported to be of use as a thiol oxidizing agent. Diamide has been used to titrate protein glutathiolation to discriminate from other oxidative protein modifications. Treatment increased protein glutathiolation in a concentration-dependent manner and had comparably little effect on protein-protein disulfide formation.

Specifications

Synonyms

TMAD | (+/-)-Secobarbital | Azodicarboxylic acid bis-dimethylamide | 1,N-dimethylformamide) | N,N',N'-Tetramethylazobisformamide | N,N,N',N'-Tetramethylazodicarboxamide | N,N,N',N'-Tetramethylazobisformamide | DIAMIDE | Tetramethyldiazenedicarboxamide | A 19315 | (E)-1,1'-azobis(N,N-dimethylformamide) | Tetramethylazodicarboxamide | Forma Show more

Specifications & Purity

≥97%(HPLC)

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥97%(HPLC)

Names and Identifiers

Pubchem Sid

504763663

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/504763663

Canonical Smiles

CN(C)C(=O)N=NC(=O)N(C)C

IUPAC Name

(3E)-3-(dimethylcarbamoylimino)-1,1-dimethylurea

InChIKey

VLSDXINSOMDCBK-BQYQJAHWSA-N

INCHI

1S/C6H12N4O2/c1-9(2)5(11)7-8-6(12)10(3)4/h1-4H3/b8-7+

Isomeric SMILES

CN(C)C(=O)/N=N/C(=O)N(C)C

WGK Germany

3

RTECS

LQ1041000

Molecular Weight

172.19

Beilstein

1910410

Reaxy-Rn

1910409

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1910409&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Class Organic carbonic acids and derivatives

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Class: Organic carbonic acids and derivatives
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Organic carbonic acids and derivatives
• Alternative Parents: Azo compounds Propargyl-type 1,3-dipolar organic compounds Organopnictogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: Carbonic acid derivative - Azo compound - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Carbonyl group - Aliphatic acyclic compound
• Description: This compound belongs to the class of organic compounds known as organic carbonic acids and derivatives. These are compounds comprising the organic carbonic acid or a derivative thereof.
• External Descriptors: 1,1'-azobis(N,N-dimethylformamide)

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

VDR Tclin Vitamin D receptor (26531 Activities)

Discover Target: VDR

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ARSA Tbio Cerebroside-sulfatase (655 Activities)

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ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)

Discover Target: ALDH1A1

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APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)

Discover Target: APEX1

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EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)

Discover Target: EHMT2

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PMP22 Tbio Peripheral myelin protein 22 (699 Activities)

Discover Target: PMP22

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CBX1 Tbio Chromobox protein homolog 1 (92434 Activities)

Discover Target: CBX1

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MPHOSPH8 Tbio M-phase phosphoprotein 8 (656 Activities)

Discover Target: MPHOSPH8

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Associated Targets(non-human)

Mycobacterium tuberculosis (203094 Activities)

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Saccharomyces cerevisiae (19171 Activities)

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pfk 6-phospho-1-fructokinase (7870 Activities)

Discover Target: pfk

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Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)

Discover Target: Txnrd1

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Mycobacterium tuberculosis variant bovis BCG (1626 Activities)

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Mapt Microtubule-associated protein tau (6 Activities)

Discover Target: Mapt

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Mechanisms of Action

Chemical and Physical Properties

• Solubility: water: 19.60-21.00 mg/mL, clear to slightly hazy, orange
• Sensitivity: air sensitive；heat sensitive
• Melt Point(°C): 113-115 °C
• Molecular Weight: 172.190 g/mol
• XLogP3: 0.200
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 172.096 Da
• Monoisotopic Mass: 172.096 Da
• Topological Polar Surface Area: 65.300 Ų
• Heavy Atom Count: 12
• Formal Charge: 0
• Complexity: 188.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 1
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 1
• Covalently-Bonded Unit Count: 1

Frequently Asked Questions

What is the purity of this product, and how is it determined?

This product is supplied at ≥97% purity, determined by HPLC. Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C under argon. It is supplied under an argon blanket; reseal under inert gas after each use.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 10465-78-8, the molecular formula is C6H12N4O2, and the molecular weight is 172.19 g/mol. InChIKey VLSDXINSOMDCBK-BQYQJAHWSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.