Determine the necessary mass, volume, or concentration for preparing a solution.
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
≥90%(GC) for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at 2-8°C,Argon charged Ships Wet ice Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 60 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
4,4′-Methylenebis(cyclohexyl isocyanate), mixture of isomers (HMDI) is an aromatic diisocyanate with good mechanical properties. It is light stable and is resistant to hydrolysis. It is majorly used in the synthesis of polyurethane.
Application
HMDI forms NCO linkages which can be used in the synthesis of polyurethanes for a variety of biomedical applications.
| Canonical Smiles | C1CC(CCC1CC2CCC(CC2)N=C=O)N=C=O |
|---|---|
| IUPAC Name | 1-isocyanato-4-[(4-isocyanatocyclohexyl)methyl]cyclohexane |
| InChIKey | KORSJDCBLAPZEQ-UHFFFAOYSA-N |
| INCHI | 1S/C15H22N2O2/c18-10-16-14-5-1-12(2-6-14)9-13-3-7-15(8-4-13)17-11-19/h12-15H,1-9H2 |
| Isomeric SMILES | C1CC(CCC1CC2CCC(CC2)N=C=O)N=C=O |
| RTECS | NQ9250000 |
| UN Number | 2206 |
| Packing Group | II |
| Molecular Weight | 262.35 |
| Reaxy-Rn | 2217800 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2217800&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organic nitrogen compounds |
| Class | Organonitrogen compounds |
| Subclass | Isocyanates |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Isocyanates |
| Alternative Parents | Propargyl-type 1,3-dipolar organic compounds Organopnictogen compounds Organooxygen compounds Organic oxides Hydrocarbon derivatives |
| Molecular Framework | Aliphatic homomonocyclic compounds |
| Substituents | Isocyanate - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Aliphatic homomonocyclic compound |
| Description | This compound belongs to the class of organic compounds known as isocyanates. These are organic compounds containing the isocyanic acid tautomer, HN=C=O, of cyanic acid, HOC#N or its hydrocarbyl derivatives RN=C=O. |
| External Descriptors | diisocyanate |
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | Sep 19, 2025 | D155475 | |
| Certificate of Analysis | Jun 26, 2025 | D155475 | |
| Certificate of Analysis | Jun 26, 2025 | D155475 | |
| Certificate of Analysis | Jun 26, 2025 | D155475 | |
| Certificate of Analysis | Jun 26, 2025 | D155475 | |
| Certificate of Analysis | Jun 26, 2025 | D155475 | |
| Certificate of Analysis | Jun 26, 2025 | D155475 | |
| Certificate of Analysis | Jun 26, 2025 | D155475 | |
| Certificate of Analysis | Sep 09, 2024 | D155475 | |
| Certificate of Analysis | Apr 12, 2024 | D155475 | |
| Certificate of Analysis | Apr 12, 2024 | D155475 | |
| Certificate of Analysis | Apr 12, 2024 | D155475 | |
| Certificate of Analysis | Apr 12, 2024 | D155475 | |
| Certificate of Analysis | Jan 10, 2024 | D155475 | |
| Certificate of Analysis | Jan 10, 2024 | D155475 | |
| Certificate of Analysis | Jan 10, 2024 | D155475 | |
| Certificate of Analysis | Jan 10, 2024 | D155475 | |
| Certificate of Analysis | Jan 10, 2024 | D155475 | |
| Certificate of Analysis | Jan 10, 2024 | D155475 | |
| Certificate of Analysis | Dec 28, 2022 | D155475 | |
| Certificate of Analysis | Dec 28, 2022 | D155475 | |
| Certificate of Analysis | Dec 28, 2022 | D155475 | |
| Certificate of Analysis | Dec 28, 2022 | D155475 | |
| Certificate of Analysis | Dec 28, 2022 | D155475 | |
| Certificate of Analysis | Dec 28, 2022 | D155475 | |
| Certificate of Analysis | Oct 31, 2022 | D155475 |
| Solubility | Soluble in water; Soluble in Acetone |
|---|---|
| Sensitivity | Moisture sensitive;Heat sensitive |
| Refractive Index | 1.5 |
| Boil Point(°C) | 168 °C/1.5 mmHg |
| Molecular Weight | 262.350 g/mol |
| XLogP3 | 5.300 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 4 |
| Exact Mass | 262.168 Da |
| Monoisotopic Mass | 262.168 Da |
| Topological Polar Surface Area | 58.900 Ų |
| Heavy Atom Count | 19 |
| Formal Charge | 0 |
| Complexity | 332.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
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| 12. Xiaobo Zhu, Wujun Zhang, Guangming Lu, Haichao Zhao, Liping Wang. (2022) Ultrahigh Mechanical Strength and Robust Room-Temperature Self-Healing Properties of a Polyurethane–Graphene Oxide Network Resulting from Multiple Dynamic Bonds. ACS Nano, [PMID:36215403] [10.1021/acsnano.2c06264] |
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| 44. Fangfang Kong, Xiaozhen Ma, Xiaobo Xu, Minghui Cui, Honglong Zhao, Jin Zhu, Jing Chen. (2024) Itaconic acid-based sustainable polyurethane covalent adaptable networks with robust mechanical, reshaping and UV-resistant properties based on reversible disulfide bond. Materials Today Chemistry, [PMID:] [10.1016/j.mtchem.2023.101881] |
| 45. Yage Hu, Yao Xiong, Yuan Wei, Jingze Liu, Tiantian Zheng, Cheng Zheng, Gaocan Li, Rifang Luo, Li Yang, Fanjun Zhang, Yunbing Wang. (2024) Polymeric artificial heart valves derived from modified diol-based polycarbonate polyurethanes. Acta Biomaterialia, [PMID:39486778] [10.1016/j.actbio.2024.10.045] |
| 46. Jinlong Fan, Jie Zhang. (2024) Preparation of Self-healing Thermoplastic Polysiloxane–Polyurea/Polyether–Polyurea Elastomer Blends with a Co-continuous Microphase Structure and In-Depth Research on Their Synergistic Effects. ACS Applied Materials & Interfaces, [PMID:39320961] [10.1021/acsami.4c12019] |
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