Digitoxin - Moligand™, 10 mM in DMSO , CAS No.71-63-6

CAS: 71-63-6 Cat. No.: D1499529 Molecular Weight: 764.94 Beilstein Registry Number: 76678 EC Number: 200-760-5

GRADE & PURITY Moligand™, 10 mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Digitoxin is an anti-cancer agent. Digitoxin induces apoptosis , inhibits influenza cytokine storm, causes DNA double-stranded breaks (DSBs) and blocks the cell cycle at the G2/M phase. Digitoxin induces calcium uptake into cells by forming transmembrane calcium channels and can be used for research of heart failure.

Specifications

Specifications & Purity

Moligand™, 10 mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Names and Identifiers

• Isomeric SMILES: C[C@@H]1[C@H]([C@H](C[C@@H](O1)O[C@@H]2[C@H](O[C@H](C[C@@H]2O)O[C@@H]3[C@H](O[C@H](C[C@@H]3O)O[C@H]4CC[C@]5([C@@H](C4)CC[C@@H]6[C@@H]5CC[C@]7([C@@]6(CC[C@@H]7C8=CC(=O)OC8)O)C)C)C)C)O)O
• WGK Germany: 3
• RTECS: IH2275000
• UN Number: 2811
• Packing Group: I
• Molecular Weight: 764.94
• Beilstein: 76678
• Reaxy-Rn: 24717874
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=24717874&ln=

Chemical and Physical Properties

• Melt Point(°C): 240 °C (dec.) (lit.)

References

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2. Jiao Xinyi, Peng Xingru, Jin Xin, Liu Ning, Yu Yang, Liu Rui, Li Zheng.  (2023)  Nano-composite system of traditional Chinese medicine for ocular applications: molecular docking and three-dimensional modeling insight for intelligent drug evaluation.  Drug Delivery and Translational Research,      [PMID:37355484] [10.1007/s13346-023-01376-x]

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4. Meiqing Zhu, Xiaohui Pang, Jie Wan, Xiaoping Xu, Xueyu Wei, Rimao Hua, Xiaoying Zhang, Yi Wang, Xiaofan Yang.  (2022)  Potential toxic effects of sulfonamides antibiotics: Molecular modeling, multiple-spectroscopy techniques and density functional theory calculations.  ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,      [PMID:35987082] [10.1016/j.ecoenv.2022.113979]

5. Hengjun Rao, Wei Qi, Rongxin Su, Zhimin He, Xin Peng.  (2020)  Mechanistic and conformational studies on the interaction of human serum albumin with rhodamine B by NMR, spectroscopic and molecular modeling methods.  JOURNAL OF MOLECULAR LIQUIDS,      [PMID:] [10.1016/j.molliq.2020.113889]

6. Shufen Wu, Xiaochan Wang, Yuxin Bao, Chuanying Zhang, Huanhuan Liu, Zhenjing Li, Mianhua Chen, Changlu Wang, Qingbin Guo, Xin Peng.  (2020)  Molecular insight on the binding of monascin to bovine serum albumin (BSA) and its effect on antioxidant characteristics of monascin.  FOOD CHEMISTRY,      [PMID:31991257] [10.1016/j.foodchem.2020.126228]

7. Xin Peng, Xiangchao Wang, Wei Qi, Rongxin Su, Zhimin He.  (2015)  Affinity of rosmarinic acid to human serum albumin and its effect on protein conformation stability.  FOOD CHEMISTRY,      [PMID:26304336] [10.1016/j.foodchem.2015.06.109]

8. Xin Peng, Xiangchao Wang, Wei Qi, Renliang Huang, Rongxin Su, Zhimin He.  (2015)  Deciphering the binding patterns and conformation changes upon the bovine serum albumin–rosmarinic acid complex.  Food & Function,  6  (8): (2712-2726).  [PMID:26146359] [10.1039/C5FO00597C]

9. Xin Peng, Wei Qi, Renliang Huang, Rongxin Su, Zhimin He.  (2015)  Elucidating the Influence of Gold Nanoparticles on the Binding of Salvianolic Acid B and Rosmarinic Acid to Bovine Serum Albumin.  PLoS One,  10  (4): (e0118274).  [PMID:25861047] [10.1371/journal.pone.0118274]

10. Peng Xin, Sun Yinhe, Qi Wei, Su Rongxin, He Zhimin.  (2014)  Study of the Interaction Between Coenzyme Q10 and Human Serum Albumin: Spectroscopic Approach.  JOURNAL OF SOLUTION CHEMISTRY,  43  (3): (585-607).  [PMID:] [10.1007/s10953-014-0146-7]

11. Xiao-Lin Xie, Zhao Zhang, Wen Xiong, Jie Wang, Wei Gong, Wen Xu, Shuang Cai, Jing Li.  (2024)  Fluorescent sensing of rutin by carbon dots derived from the heart of cumin seeds.  Arabian Journal of Chemistry,      [PMID:] [10.1016/j.arabjc.2024.105888]

12. Wu Huaxin, Huang Ting, Zhang Wei, Yao Huan, Li Xueyao, Su Ping, Yang Yi.  (2025)  Purity determination of digitoxin by two-signal suppression–internal standard correction–high-performance liquid chromatography–quantitative nuclear magnetic resonance.  ANALYTICAL AND BIOANALYTICAL CHEMISTRY,      [PMID:40119928] [10.1007/s00216-025-05836-w]

13. Huilin Liu, Chao Huang, Zhenni Liu, Yuhan Li, Yanan Zhu, Min Gao, Jing Chen, Hui Zhang, Zhengtao Xiao, Wei Zhao.  (2024)  Systematic drug screening and target analysis identify digitoxin as a potential therapy for uveal melanoma.  BRITISH JOURNAL OF PHARMACOLOGY,      [PMID:39617007] [10.1111/bph.17405]

14. Junqiao Zhou, Jiayin Li, Cong Cheng, YuJuan Yao, Yu Li, Hao Liu, Laiyan Wu.  (2024)  Unraveling the binding behavior of the antifouling biocide 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one with human serum albumin: Multi-spectroscopic, atomic force microscope, computational simulation, and esterase activity.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:38906347] [10.1016/j.ijbiomac.2024.133266]