10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 32 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
Dihydromyricetin (Ampelopsin, Ampeloptin) is a natural antioxidant flavonoid from Ampelopsis grossedentata.
In vitro
Dihydromyricetin shows antioxidant activity as an effective scavenger of 1,1-diphenyl-2-picrylhydrazyl radical (DPPH). It also inhibits the increase of lipid peroxidation (LPO) values in linolei acid system catalyzed by FeSO4-edetic acid. DHM (1 μM) as a novel anti-alcohol intoxication medication antagonizes both acute EtOH-induced potentiation of GABA(A)Rs and EtOH exposure/withdrawal-induced GABA(A)R plasticity and increases in GABA(A)R alpha4 subunit expression in hippocampus and cultured neurons.
In vivo
Dihydromyricetin (1 mg/kg, i.p.) counteracts acute alcohol (EtOH) intoxication, and also withdrawals signs in rats including tolerance, increased anxiety, and seizure susceptibity. LD50: Mice 1.41g/kg (i.p.)
Cell Data
cell lines：
Concentrations：
Incubation Time：
Powder Purity:≥99%
| Isomeric SMILES | C1=C(C=C(C(=C1O)O)O)[C@@H]2[C@H](C(=O)C3=C(C=C(C=C3O2)O)O)O |
|---|---|
| WGK Germany | 3 |
| Molecular Weight | 320.25 |
| Reaxy-Rn | 332335 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=332335&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| Solubility | Solubility (25°C) In vitro DMSO: 57 mg/mL (199.13 mM); Water: Insoluble; Ethanol: Insoluble; |
|---|---|
| Specific Rotation[α] | +15.5 to +17.0 deg(C=0.9, methanol) |
| Melt Point(°C) | 248 °C |
| 1. Chengyun He, Lu Bai, Daqun Liu, Benguo Liu. (2023) Interaction mechanism of okra (Abelmoschus esculentus L.) seed protein and flavonoids: Fluorescent and 3D-QSAR studies. Food Chemistry-X, [PMID:38144792] [10.1016/j.fochx.2023.101023] |
| 2. Dongqing Zhang, Wenqi Liu, Ke Ye, Xiaojin Li. (2023) High CO and sulfur tolerant proton exchange membrane fuel cell anodes enabled by “work along both lines” mechanism of 2,6-dihydroxymethyl pyridine molecule blocking layer. JOURNAL OF COLLOID AND INTERFACE SCIENCE, [PMID:37722170] [10.1016/j.jcis.2023.09.076] |
| 3. Songqi Liu, Zaihan Chen, Huange Zhang, Yuanli Li, Taxipalati Maierhaba, Jianhui An, Zhi Zhou, Lingli Deng. (2022) Comparison of eugenol and dihydromyricetin loaded nanofibers by electro-blowing spinning for active packaging. Food Bioscience, [PMID:] [10.1016/j.fbio.2022.102294] |
| 4. Jie Zhao, Lin Huang, Renjie Li, Zhuangwei Zhang, Jin Chen, Hongjin Tang. (2022) Insights from multi-spectroscopic analysis and molecular modeling to understand the structure–affinity relationship and the interaction mechanism of flavonoids with gliadin. Food & Function, 13 (9): (5061-5074). [PMID:35404372] [10.1039/D1FO03816H] |
| 5. Xu Jinfang, Li Xinying, Xu Yaqin, Wang Anqi, Xu Zhilang, Wu Xia, Li Defu, Mu Changdao, Ge Liming. (2021) Dihydromyricetin-Loaded Pickering Emulsions Stabilized by Dialdehyde Cellulose Nanocrystals for Preparation of Antioxidant Gelatin–Based Edible Films. Food and Bioprocess Technology, 14 (9): (1648-1661). [PMID:] [10.1007/s11947-021-02664-5] |
| 6. Qian Zhou, Jia-Yi Yin, Wei-Yue Liang, Dong-Mei Chen, Qing Yuan, Bao-long Feng, Ying-Hua Zhang, Yu-Tang Wang. (2021) Various machine learning approaches coupled with molecule simulation in the screening of natural compounds with xanthine oxidase inhibitory activity. Food & Function, 12 (4): (1580-1589). [PMID:33470259] [10.1039/D0FO03059G] |
| 7. Hongjin Tang, Lin Huang, Dongsheng Zhao, Chunyong Sun, Ping Song. (2020) Interaction mechanism of flavonoids on bovine serum albumin: Insights from molecular property-binding affinity relationship. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, [PMID:32480277] [10.1016/j.saa.2020.118519] |
| 8. Jie Zhao, Lin Huang, Chunyong Sun, Dongsheng Zhao, Hongjin Tang. (2020) Studies on the structure-activity relationship and interaction mechanism of flavonoids and xanthine oxidase through enzyme kinetics, spectroscopy methods and molecular simulations. FOOD CHEMISTRY, [PMID:32330646] [10.1016/j.foodchem.2020.126807] |
| 9. Chengyun He, Xiaoling Liu, Zhaojing Jiang, Sheng Geng, Hanjun Ma, Benguo Liu. (2019) Interaction Mechanism of Flavonoids and α-Glucosidase: Experimental and Molecular Modelling Studies. Foods, 8 (9): (355). [PMID:31438605] [10.3390/foods8090355] |
| 10. Hao Liu, Wenmei Zhao, Qi Hu, Ling Zhao, Yumeng Wei, Chao Pi, Yuhan Yang, Xuerong Yang, Hang Yuan, Yuhan Zhang, Kunyan Qu, Xinyu Shi, Yao Huang, Houyin Shi. (2019) Gastric floating sustained-release tablet for dihydromyricetin: Development, characterization, and pharmacokinetics study. SAUDI PHARMACEUTICAL JOURNAL, [PMID:31997907] [10.1016/j.jsps.2019.08.002] |
| 11. Meihui Fan, Huafang Ding, Guowen Zhang, Xing Hu, Deming Gong. (2019) Relationships of dietary flavonoid structure with its tyrosinase inhibitory activity and affinity. LWT-FOOD SCIENCE AND TECHNOLOGY, [PMID:] [10.1016/j.lwt.2019.02.076] |
| 12. Shuzhen Yang, Jie Zhou, Dongmei Li, Chunyu Shang, Litao Peng, Siyi Pan. (2016) The structure-antifungal activity relationship of 5,7-dihydroxyflavonoids against Penicillium italicum. FOOD CHEMISTRY, [PMID:28159264] [10.1016/j.foodchem.2016.12.001] |
| 13. Shian Zhong, Yanyue Kong, Ling Zhou, Chengyun Zhou, Xiaona Zhang, Yan Wang. (2013) Efficient conversion of myricetin from Ampelopsis grossedentata extracts and its purification by MIP-SPE. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, [PMID:24321759] [10.1016/j.jchromb.2013.11.036] |
| 14. Fei Wang, Xiang Yu, Haojie Li, Ming Li, Qimin Feng. (2013) Graphene-Nafion Composite Film Modified Electrode for Voltammetric Sensor for Determination of Dihydromyricetin. JOURNAL OF THE CHINESE CHEMICAL SOCIETY, 60 (8): (1019-1026). [PMID:] [10.1002/jccs.201300020] |
| 15. Chao-Yue Sun, Wan-Qing Li, Jing-Wen Lu, Ao-Yue Zhang, Qing-Xia Chu, Li Tang, Wei Gao, Jin-Jie Cai, Ying Lu, Dong Liu. (2025) Ampelopsis grossedentata protects against ethanol-induced acute duodenal injury by inhibiting TNF-triggered caspases-dependent apoptosis in mice. JOURNAL OF ETHNOPHARMACOLOGY, [PMID:40854417] [10.1016/j.jep.2025.120462] |
| 16. Mingxiang Lu, Renzhi Liu, Zhifei Chen, Chen Su, Luqing Pan. (2023) Effects of dietary dihydromyricetin on growth performance, antioxidant capacity, immune response and intestinal microbiota of shrimp (Litopenaeus vannamei). FISH & SHELLFISH IMMUNOLOGY, [PMID:37722436] [10.1016/j.fsi.2023.109086] |
| 17. Shiyu Zhen, Sheng Geng, Hanjun Ma, Benguo Liu. (2022) Interaction of α-lactalbumin with dihydromyricetin and its application in nano-emulsion. INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY, 58 (3): (1120-1129). [PMID:] [10.1111/ijfs.16255] |
| 18. Han Peng, Zeyuan Deng, Xuan Chen, Yong Sun, Bing Zhang, Hongyan Li. (2018) Major chemical constituents and antioxidant activities of different extracts from the peduncles of Hovenia acerba Lindl. INTERNATIONAL JOURNAL OF FOOD PROPERTIES, [PMID:] [10.1080/10942912.2018.1497059] |
| 19. Umair Muhammad, Hedong Lu, Juan Wang, Jinzhi Han, Xiaoyu Zhu, Zhaoxin Lu, Sultana Tayyaba, Yousef I. Hassan. (2017) Optimizing the Maximum Recovery of Dihydromyricetin from Chinese Vine Tea, Ampelopsis grossedentata, Using Response Surface Methodology. MOLECULES, 22 (12): (2250). [PMID:29258286] [10.3390/molecules22122250] |
| 20. Han Peng, Wenting Li, Hongyan Li, Zeyuan Deng, Bing Zhang. (2017) Extractable and non-extractable bound phenolic compositions and their antioxidant properties in seed coat and cotyledon of black soybean (Glycinemax (L.) merr). Journal of Functional Foods, [PMID:] [10.1016/j.jff.2017.03.003] |
| 21. Shimei Qi, Xianjuan Kou, Jun Lv, Zhilin Qi, Liang Yan. (2015) Ampelopsin induces apoptosis in HepG2 human hepatoma cell line through extrinsic and intrinsic pathways: Involvement of P38 and ERK. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, [PMID:26476886] [10.1016/j.etap.2015.09.015] |
| 22. Yimei Zheng, Boyu Chen, Xuanxiang Huang, Xiamei Tao, Chao Ai, Yanan Zhao, Peng Liang, Lei Chen. (2024) A designed self-microemulsifying delivery system: Stability and Anti-inflammation in vivo enhancement of dihydromyricetin. Journal of Functional Foods, [PMID:] [10.1016/j.jff.2024.106266] |
| 23. Xiaojing Si, Yue Huang, Mei Han, Liqiang Luo. (2025) Electrochemical Sensor Based on Co-MOF for the Detection of Dihydromyricetin in Ampelopsis grossedentata. MOLECULES, 30 (1): (180). [PMID:39795236] [10.3390/molecules30010180] |
| 24. Yucan Zhang, Chenxi Shi, Jin Yuan, Yue Zhang, Xiaohui Jin, Shaopo Zu, Honglei Zhang, Hui Hu. (2024) Rapid Construction of Recombinant PDCoV Expressing an Enhanced Green Fluorescent Protein for the Antiviral Screening Assay Based on Transformation-Associated Recombination Cloning in Yeast. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, [PMID:38181302] [10.1021/acs.jafc.3c08327] |
| 25. Mingxiang Lu, Futao Jing, Renzhi Liu, Zhifei Chen, Ruixue Tong, Yaobing Li, Luqing Pan. (2024) The effects and mechanisms of dietary ferulic acid (FA) and dihydromyricetin (DMY) on growth and physiological responses of the shrimp (Litopenaeus vannamei). AQUACULTURE, [PMID:] [10.1016/j.aquaculture.2024.740967] |
| 26. Yi Wu, Shuohan He, Meng Li, Yan Li, Shaopeng Liu, Hongwei Xiong, Qianxiang Meng, Peng Liu, Kaiyong Cai. (2025) Breaking Age-Impaired Bone Healing Challenge: Smart Hydrogel-Coated Implant Reprograms Aging Bone Microenvironments via Senolytic and Pro-Angiogenic Dual Therapy. Advanced Healthcare Materials, [PMID:40947643] [10.1002/adhm.202501928] |
| 27. Yuwen Guan, Qiuyue Lv, Xinyu Wang, Baoping Jiang, Peigen Xiao. (2025) Dihydromyricetin as a Dietary Supplement Enhances Hypoglycemic Efficacy: Synergistic Modulation of the Gut-Liver with Sangzhi Alkaloids. Food Bioscience, [PMID:] [10.1016/j.fbio.2025.106197] |
| 28. Ze-Rui Sun, Hui-Zhen Peng, Mao-Si Fan, Dong Chang, Ming-Yue Wang, Meng-Fei An, Li-Juan Zhang, Rui Zan, Jun Sheng, Yun-Li Zhao, Xuan-Jun Wang. (2025) Dihydromyricetin ameliorates hyperuricemia through inhibiting uric acid reabsorption. JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, [PMID:40202030] [10.1002/jsfa.14126] |
| 29. Jia Li, Lijia Li, Tahui Lin, Houtan Huang, Jie Ren, Jengyuan Yao. (2025) Dihydromyricetin preserves β-cell function in type 1 diabetes via PI3K/AKT-mediated metabolic reprogramming. Frontiers in Nutrition, [PMID:41112749] [10.3389/fnut.2025.1682308] |
| 30. Ling Tang, Jinqing Chen, Jiali Luo, Huijuan Wei, Lina Lan, Hailan Qin, Qiumei He, Xiangyu Kong, Liting Lai, Wenya Ding, Jian Xiao. (2025) Dihydromyricetin-loaded TPGS/gelatin grafted-β-Cyclodextrin/ chitosan grafted-β-Cyclodextrin nano-delivery system for improving oral absorption. FOOD RESEARCH INTERNATIONAL, [PMID:41652702] [10.1016/j.foodres.2025.118296] |
| 31. Gerui Ren, Ruiqi Hu, Jiajun Mao, Xinpei Cai, Tianrong Wang, Xin Song, Wentao Wu, Caixin Zhuge, Min Huang, Hujun Xie, Kejun Cheng. (2026) From poor solubility to precision delivery: Zein–κ-carrageenan nanovehicles unlock dihydromyricetin's bioactive potential. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, [PMID:41708022] [10.1016/j.ijbiomac.2026.150961] |
| 32. Shen Yemei, Gao Xuemei, Huan Xuanrong, He Cui, Liu Yu, Li Yuan. (2026) Dihydromyricetin exhibits potent antiplatelet activity with minimal impact on coagulation system: an in vitro study. BLOOD COAGULATION & FIBRINOLYSIS, [PMID:41693263] [10.1097/MBC.0000000000001416] |
