Dimethyl Fumarate - Moligand™, 10mM in DMSO , Kelch-like ECH-associated protein 1 inhibitor, CAS No.624-49-7, Kelch-like ECH-associated protein 1 inhibitor

CAS: 624-49-7 Cat. No.: D408186 Molecular Weight: 144.13 Beilstein Registry Number: 774590 EC Number: 210-849-0

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

DMF | (2E)​-​2-​butenedioic acid 1,​4-​dimethyl ester

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Dimethyl Fumarate Dimethyl fumarate (DMF) is the methyl ester of fumaric acid, used to treat people with relapsing forms of multiple sclerosis. Dimethyl fumarate is a nuclear factor (erythroid-derived)-like 2 (Nrf2) pathway activator and induces upregul
In vitro

Dimethyl fumarate causes short-lived oxidative stress, which leads to increased levels and nuclear localization of the transcription factor nuclear factor erythroid 2-related factor 2 and a subsequent increase in glutathione synthesis and recycling in neuronal cells. Dimethyl fumarate inhibits dendritic cell (DC) maturation by reducing inflammatory cytokine production (IL-12 and IL-6) and the expression of MHC class II, CD80, and CD86. Dimethyl fumarate impairs nuclear factor κB (NF-κB) signaling via reduced p65 nuclear translocalization and phosphorylation. Dimethyl fumarate inhibits maturation of DCs and subsequently Th1 and Th17 cell differentiation by suppression of both NF-κB and ERK1/2-MSK1 signaling. Dimethyl fumarate inhibits TNF-alpha-induced nuclear entry of NF-kappaB in rat heart endothelial cells (RHEC). Dimethyl fumarate, an immune modulator and inducer of the antioxidant response, suppresses HIV replication and neurotoxin release. Dimethyl fumarate attenuates CCL2-induced monocyte chemotaxis, suggesting that Dimethyl fumarate could decrease recruitment of activated monocytes to the CNS in response to inflammatory mediators.

In vivo

Dimethyl fumarate inhibits nuclear entry of NF-kappaB in RHEC and reduces myocardial infarct size after ischemia and reperfusion in rats in vivo. Dimethyl fumarate oral administration is shown to upregulate mRNA and protein levels of Nrf2 and Nrf2-regulated cytoprotective genes, attenuate 6-OHDA induced striatal oxidative stress and inflammation in C57BL/6 mice.
Cell Data

cell lines：HNE1 and CNE1-LMP1

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyms

DMF | (2E)​-​2-​butenedioic acid 1, ​4-​dimethyl ester

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

Dimethyl fumarate (DMF) is the methyl ester of fumaric acid, used to treat people with relapsing forms of multiple sclerosis. Dimethyl fumarate is a nuclear factor (erythroid-derived)-like 2 (Nrf2) pathway activator and induces upregulation of antioxidant

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

INHIBITOR

Mechanism of action

Kelch-like ECH-associated protein 1 inhibitor

Names and Identifiers

• Isomeric SMILES: COC(=O)/C=C/C(=O)OC
• WGK Germany: 1
• RTECS: EM6125000
• Molecular Weight: 144.13
• Beilstein: 774590
• Reaxy-Rn: 8137488
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=8137488&ln=

Chemical and Physical Properties

• Boil Point(°C): 193°C
• Melt Point(°C): 103—104°C

References

1. Caihong Wang, Yong Liu, Fengshen Han, Yongzhe Han, Tianyu Liu, Haitao Ren, Xu Han.  (2023)  Nitrogen-doped carbocatalyst activated persulfate (PS) for oxidation polymerization of bisphenol A (BPA): importance of nonradical activation of PS.  PHYSICAL CHEMISTRY CHEMICAL PHYSICS,  25  (19): (13716-13727).  [PMID:37158256] [10.1039/D3CP00659J]

2. Shao-Qi Zhi, Jun-Yuan Zhang, Song-Hai Wu, Wen-Shuang Zhu, Yu-Dong Shan, Yong Liu, Xu Han.  (2023)  Oxidative Desulfurization of Benzothiophene by Persulfate and Cu-Loaded g-C3 N4 via the Polymerization Pathway.  INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH,      [PMID:] [10.1021/acs.iecr.2c04484]

3. Xin‐Lin Zhang, Ting‐Yu Wang, Zheng Chen, Hong‐Wei Wang, Yong Yin, Lian Wang, Yong Wang, Biao Xu, Wei Xu.  (2022)  HMGB1‐Promoted Neutrophil Extracellular Traps Contribute to Cardiac Diastolic Dysfunction in Mice.  Journal of the American Heart Association,      [PMID:35156391] [10.1161/JAHA.121.023800]

4. Tian-Yu Liu, Cong Wang, Yong-Zhe Han, Chang Bai, Hai-Tao Ren, Yong Liu, Xu Han.  (2022)  Oxidative polymerization of bisphenol A (BPA) via H-abstraction by Bi2.15WO6 and persulfate: Importance of the surface complexes.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2022.134816]

5. Chang Bai, Yong Liu, Cong Wang, Xiao-Cong Zhang, Jia-Xuan Wu, Hai-Tao Ren, Xu Han.  (2021)  Conversion of aniline contaminant to valuable polyaniline polymers from wastewater under alkaline conditions.  Molecular Catalysis,      [PMID:] [10.1016/j.mcat.2021.111430]

6. Xiao-Cong Zhang, Song-Hai Wu, Shao-Yi Jia, Cong Wang, Shi-Wei Sun, Xiang-Ming Wang, Zi-He Meng, Yi-Ying Lin, Yong Liu, Hai-Tao Ren, Xu Han.  (2020)  Turning thiophene contaminant into polymers from wastewater by persulfate and CuO.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2020.125351]

7. Haiyan Zhu, Yijing Yang, Yenan Duan, Xin Zheng, Zixiong Lin, Jie Zhou.  (2024)  Nrf2/FSP1/CoQ10 axis-mediated ferroptosis is involved in sodium aescinate-induced nephrotoxicity.  ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS,      [PMID:39033970] [10.1016/j.abb.2024.110100]

8. Xin Zheng, Xinyi Tang, Yinan Xu, Haiyan Zhu, Lianwei Zhong, Chen Chen, Jiajun Cui, Jie Zhou.  (2025)  Sodium aescinate induces hepatotoxicity through apoptosis and ferroptosis by inhibiting the Nrf2/CTH pathway.  JOURNAL OF ETHNOPHARMACOLOGY,      [PMID:40064321] [10.1016/j.jep.2025.119608]