Dioscin - Moligand™, 10mM in DMSO , Antagonist of CXCR3, CAS No.19057-60-4, Antagonist of CXCR3

CAS: 19057-60-4 Cat. No.: D408362 Formula: C₄₅H₇₂O₁₆ Molecular Weight: 869.05 EC Number: 866-819-8

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

Collettiside III, Saponin | β-D-Glucopyranoside, (3β,25R)-spirost-5-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[6-deoxy-α-L-mannopyranosyl-(1→4)]-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Dioscin (Collettiside III, Saponin) is a saponin extracted and isolated from Polygonatum Zanlanscianense Pamp, showing antitumor activities.
In vitro

Dioscin is extracted and isolated from Polygonatum Zanlanscianense Pamp with IC50 of 2.6, 0.8, 7.5, and 4.5 μM for the inhibition of the growth of the MDA-MB-435, H14, HL60, and HeLa cell lines, respectively. Dioscin induces apotosis in Hela cells by down regulating caspase-8 activity and up regulating caspase-9 activity.

In vivo

LD50: Mice >300mg/kg
Cell Data

cell lines：Mesangial cells

Concentrations：

Incubation Time：

Powder Purity:

Specifications

Synonyms

Collettiside III, Saponin | β-D-Glucopyranoside, (3β,25R)-spirost-5-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[6-deoxy-α-L-mannopyranosyl-(1→4)]-

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

Dioscin (Collettiside III, Saponin) is a saponin extracted and isolated from Polygonatum Zanlanscianense Pamp, showing antitumor activities.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

ANTAGONIST

Mechanism of action

Antagonist of CXCR3

Names and Identifiers

Isomeric SMILES

C[C@@H]1CC[C@@]2([C@H]([C@H]3[C@@H](O2)C[C@@H]4[C@@]3(CC[C@H]5[C@H]4CC=C6[C@@]5(CC[C@@H](C6)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)CO)O[C@H]8[C@@H]([C@@H]([C@H]([C@@H](O8)C)O)O)O)O)O[C@H]9[C@@H]([C@@H]([C@H]([C@@H](O9)C)O)O)O)C)C)C)OC1

Alternate CAS

19057-60-4

MeSH Entry Terms

dioscin

Molecular Weight

869.05

Reaxy-Rn

42293031

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=42293031&ln=

Associated Targets(Human)

CXCR3 Tchem C-X-C chemokine receptor type 3 (1 Activities)

Discover Target: CXCR3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)