Diphenhydramine Hydrochloride - ≥98%(HPLC) , Histamine H1 receptor antagonist, CAS No.147-24-0, Histamine H1 receptor antagonist

Name: Diphenhydramine Hydrochloride - ≥98%(HPLC) , Histamine H1 receptor antagonist, CAS No.147-24-0, Histamine H1 receptor antagonist
Brand: Aladdin Scientific
SKU: D129201
Availability: InStock

CAS: 147-24-0 Cat. No.: D129201 Molecular Weight: 291.82 EC Number: 205-687-2

3 Citations COA

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Diphenhydramine Hydrochloride - ≥98%(HPLC) CAS No(147-24-0) by Aladdin Scientific

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AVAILABLE TO ORDER

GRADE & PURITY ≥98%(HPLC)

Synonyms

Storage

Store at 2-8°C,Protected from light

Shipped In

Wet ice

Overview Specifications Names and Identifiers Documentation Advanced Data Taxonomic Classification 3D Structure Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Citations of This Product References Solution Calculators Reviews

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Why this grade

≥98%(HPLC) for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at 2-8°C,Protected from light Ships Wet ice Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 3 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

A histamine H1-receptor antagonist.

Specifications

Synonyms

Specifications & Purity

≥98%(HPLC)

Biochemical and Physiological Mechanisms

Potent H 1 receptor antagonist (K i = 1 nM). Shows antihistaminergic, antiemetic, sedative and hypnotic effects.

Storage

Store at 2-8°C, Protected from light

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

ANTAGONIST

Mechanism of action

Histamine H1 receptor antagonist

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥98%(HPLC)

Names and Identifiers

Canonical Smiles	CN(C)CCOC(C1=CC=CC=C1)C2=CC=CC=C2.Cl
IUPAC Name	2-benzhydryloxy-N,N-dimethylethanamine;hydrochloride
InChIKey	PCHPORCSPXIHLZ-UHFFFAOYSA-N
INCHI	1S/C17H21NO.ClH/c1-18(2)13-14-19-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16;/h3-12,17H,13-14H2,1-2H3;1H
Isomeric SMILES	CN(C)CCOC(C1=CC=CC=C1)C2=CC=CC=C2.Cl
WGK Germany	3
RTECS	KR7000000
Molecular Weight	291.82
Reaxy-Rn	3918132
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3918132&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Benzenoids
  - Class Benzene and substituted derivatives
    - Subclass Diphenylmethanes

Kingdom	Organic compounds
Superclass	Benzenoids
Class	Benzene and substituted derivatives
Subclass	Diphenylmethanes
Intermediate Tree Nodes	Not available
Direct Parent	Diphenylmethanes
Alternative Parents	Benzylethers Trialkylamines Dialkyl ethers Organopnictogen compounds Hydrochlorides Hydrocarbon derivatives
Molecular Framework	Aromatic homomonocyclic compounds
Substituents	Diphenylmethane - Benzylether - Tertiary aliphatic amine - Tertiary amine - Ether - Dialkyl ether - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Hydrocarbon derivative - Hydrochloride - Organooxygen compound - Organonitrogen compound - Amine - Aromatic homomonocyclic compound
Description	This compound belongs to the class of organic compounds known as diphenylmethanes. These are compounds containing a diphenylmethane moiety, which consists of a methane wherein two hydrogen atoms are replaced by two phenyl groups.
External Descriptors	hydrochloride - organoammonium salt
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

3D Structure

Associated Targets(Human)

ESR1 Tclin Estrogen receptor alpha (17718 Activities)

Discover Target: ESR1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KCNH2 Tclin HERG (29587 Activities)

Discover Target: KCNH2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

THRB Tclin Thyroid hormone receptor beta-1 (7926 Activities)

Discover Target: THRB

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RXRA Tclin Retinoid X receptor alpha (3637 Activities)

Discover Target: RXRA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ACHN (49357 Activities)

Lot Number	Certificate Type	Date	Item
G1629048	Certificate of Analysis	Sep 16, 2025	D129201
L2306111	Certificate of Analysis	Sep 09, 2025	D129201
B2224196	Certificate of Analysis	Sep 09, 2025	D129201
B2224203	Certificate of Analysis	Sep 09, 2025	D129201
B2224216	Certificate of Analysis	Sep 09, 2025	D129201
B2224278	Certificate of Analysis	Sep 09, 2025	D129201
E2512081	Certificate of Analysis	May 15, 2025	D129201
L2410671	Certificate of Analysis	Jun 17, 2024	D129201
L2410673	Certificate of Analysis	Jun 17, 2024	D129201
L2417053	Certificate of Analysis	Jun 17, 2024	D129201
A2604071	Certificate of Analysis	Jun 14, 2024	D129201
L2410666	Certificate of Analysis	Jun 14, 2024	D129201
L2410667	Certificate of Analysis	Jun 14, 2024	D129201
L2410669	Certificate of Analysis	Jun 14, 2024	D129201
I2124092	Certificate of Analysis	Jul 14, 2023	D129201
C2024094	Certificate of Analysis	Jan 25, 2022	D129201

Solubility	Soluble in water (1000 mg/ml), DMSO (58 mg/ml at 25 °C), DMF (~10 mg/ml), methanol, and ethanol (500 mg/ml).
Sensitivity	Light sensitive
Melt Point(°C)	170°C
Molecular Weight	291.800 g/mol
XLogP3
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	6
Exact Mass	291.139 Da
Monoisotopic Mass	291.139 Da
Topological Polar Surface Area	12.500 Å²
Heavy Atom Count	20
Formal Charge	0
Complexity	211.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	2

Diphenhydramine Hydrochloride - ≥98%(HPLC) , Histamine H1 receptor antagonist, CAS No.147-24-0, Histamine H1 receptor antagonist

Why this grade

Storage & shipping

Quality documents

Literature proof

Overview

Specifications

Documentation

📋 Safety Data Sheet (SDS)

✅ Certificate of Analysis (COA)

📊 Datasheet

🔬 Specification Sheet

Advanced Data

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