Diphtheria Toxin(CRM197), CAS No.MFCD00163490

CAS: MFCD00163490 Cat. No.: D684675

GRADE & PURITY ≥95%

Overview

The diphtheria toxin of Corynebacterium diphtheriae has been used in: microglia depletion, study of post-traumatic stress disorder in mice; Intraperitoneally injected in transgenic mice to select hybrids after fusion of transplanted hematopoietic stem cells and progenitor cells (HSPCs) during ablation; To study the effect on eosinophilic lineal transformed progenitor cells in eosinophilic deficient mouse strain (iPHIL).

Diphtheria toxin can be used as a toxin element in the construction of cell-specific cytotoxic immunotoxins. Bacterial toxin translocation domains with natural endosome escape mechanisms have been used to develop effective non-viral vectors for gene therapy.

Specifications

Product Name

Diphtheria Toxin(CRM197), CAS No.MFCD00163490

Synonyms

Diphtheria Toxin is known as an intact toxin.

Specifications & Purity

≥95%

Biochemical and Physiological Mechanisms

Diphtheria toxin is a bacterial toxin produced by Corynebacterium diphtheriae. It contains three domains with intracellular roles. These domains are involved in cell poisoning, cell surface binding and internalization into endosomes, transport across endo

Sequence

MGADDVVDSS KSFVMENFSS YHGTKPGYVD SIQKGIQKPK SGTQGNYDDD WKGFYSTDNK HDAAGYSVDN ENPLSGKAGG VVKVTYPGLT KVLALKVDNA ETIKKELGLS LTEPLMEQVG TEEFIKRFGD GASRVVLSLP FAEGSSSVEY INNWEQAKAL SVELEINFET RGKRGQDAKY EYMAQACAGN RVRRSVGSSL SCINLDWDVI RDKTKTKIES LKEHGPIKNK MSESPNKTVS EEKAKQYLEE FHQTALEHPE LSELKTVTGT NPVFAGANYA AWAVNVAQVI DSETADNLEK TTAALSILPG IGSVMGIADG AVHHNTEEIV AQSIALSSLM VAQAIPLVGE LVDIGFAAYN FVESIINLFQ VVHNSYNRPA YSPGHKTQPF LHHHHHH

CAS

MFCD00163490

Molecule Type

Protein

Storage and Shipping

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

References

1. Jianwen Su, Sushuang Ma, Mankai Yang, Jichang Wu, Yijie Chen, Mingchao Jin, Qin Shi, Xianrong Zhang.  (2025)  The protective role of adipogenic lineage precursors in maintaining bone marrow redox homeostasis in a mouse model of prenatal dexamethasone exposure.  Redox Biology,      [PMID:40845776] [10.1016/j.redox.2025.103820]