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DS1 - Moligand™ , CAS No.372497-52-4

CAS: 372497-52-4 Cat. No.: D346530 Molecular Weight: 511.62 EC Number: 684-519-3
COA
DS1 - Moligand™ CAS No(372497-52-4) by Aladdin Scientific
AVAILABLE TO ORDER
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.
Synonyms
8R2YWY4LXF | 4-Chloro-N-[6,8-dibromo-2-(2-thienyl)imidazo[1,2-a]pyridin-3-yl]benzamide | GTPL4183 | BDBM50457439 | 4-Chloro-N-[6,8-dibromo-2-(2-thienyl)imidazo[1,2-a]pyridine-3-yl]benzamide | AKOS001667044 | DS1 | DTXSID60359667 | Q5206094 | EN300-1850125
Storage
Store at 2-8°C
Shipped In
Wet ice
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 ·  off list, applied to all prices below.
Size
Status
Price
Qty
5mg
D346530-5mg
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.
$210.90
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SDS
Safety data
COA
Certificate
DS
Datasheet
SP
Spec sheet
Overview Specifications Names and Identifiers Documentation Advanced Data Taxonomic Classification 3D Structure Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Solution Calculators Reviews
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Why this grade

Moligand™ Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at 2-8°C Ships Wet ice Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

Potently (low nM) enhances GABA-evoked currents mediated by α4β3δ receptors. It has little effect on GABA responses mediated by α4β3 2 receptors. At similar concentrations, DS1 directly activates this receptor and is the most potent known agonist of α4β3δ receptors. This compound has an opportunity to be become an agonist golden stardard for δ-GABA|A|receptors.

Specifications

Synonyms
8R2YWY4LXF | 4-Chloro-N-[6, 8-dibromo-2-(2-thienyl)imidazo[1, 2-a]pyridin-3-yl]benzamide | GTPL4183 | BDBM50457439 | 4-Chloro-N-[6, 8-dibromo-2-(2-thienyl)imidazo[1, 2-a]pyridine-3-yl]benzamide | AKOS001667044 | DS1 | DTXSID60359667 | Q5206094 | EN300-1850125
Specifications & Purity
Moligand™
Storage
Store at 2-8°C
Shipped In
Wet ice
This product requires cold chain shipping. Ground and other economy services are not available.
Grade
Moligand™
Action Type
AGONIST
Names and Identifiers
Canonical SmilesC1=CSC(=C1)C2=C(N3C=C(C=C(C3=N2)Br)Br)NC(=O)C4=CC=C(C=C4)Cl
IUPAC Name4-chloro-N-(6,8-dibromo-2-thiophen-2-ylimidazo[1,2-a]pyridin-3-yl)benzamide
InChIKeyMEWSBNIVOLYKGU-UHFFFAOYSA-N
INCHI1S/C18H10Br2ClN3OS/c19-11-8-13(20)16-22-15(14-2-1-7-26-14)17(24(16)9-11)23-18(25)10-3-5-12(21)6-4-10/h1-9H,(H,23,25)
Isomeric SMILES C1=CSC(=C1)C2=C(N3C=C(C=C(C3=N2)Br)Br)NC(=O)C4=CC=C(C=C4)Cl
WGK Germany 3
Molecular Weight 511.62
Reaxy-Rn 29648785
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=29648785&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

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📊 Datasheet

Quick-reference summary of product specifications and applications.

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🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassBenzenoids
ClassBenzene and substituted derivatives
SubclassBenzoic acids and derivatives
Intermediate Tree Nodes Halobenzoic acids and derivatives
Direct Parent4-halobenzoic acids and derivatives
Alternative Parents Benzamides  Imidazo[1,2-a]pyridines  Imidazopyridines  Benzoyl derivatives  Polyhalopyridines  Chlorobenzenes  Aryl bromides  Aryl chlorides  N-substituted imidazoles  Heteroaromatic compounds  Thiophenes  Secondary carboxylic acid amides  Azacyclic compounds  Organonitrogen compounds  Organooxygen compounds  Hydrocarbon derivatives  Organopnictogen compounds  Organic oxides  Organobromides  Organochlorides  
Molecular FrameworkAromatic heteropolycyclic compounds
Substituents 4-halobenzoic acid or derivatives - Imidazopyridine - Imidazo[1,2-a]pyridine - Benzamide - Polyhalopyridine - Benzoyl - Halobenzene - Chlorobenzene - Aryl halide - Aryl chloride - Pyridine - Aryl bromide - N-substituted imidazole - Thiophene - Imidazole - Azole - Heteroaromatic compound - Carboxamide group - Secondary carboxylic acid amide - Azacycle - Organoheterocyclic compound - Carboxylic acid derivative - Organonitrogen compound - Organooxygen compound - Organic oxygen compound - Organic nitrogen compound - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organochloride - Organobromide - Organohalogen compound - Aromatic heteropolycyclic compound
DescriptionThis compound belongs to the class of organic compounds known as 4-halobenzoic acids and derivatives. These are benzoic acids or derivatives carrying a halogen atom at the 4-position of the benzene ring.
External Descriptors Not available
3D Structure
Interactive Chemical Structure Model





Associated Targets(Human)
GABRA1 Tclin GABA-A receptor; alpha-1/beta-3/gamma-2 (1565 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GABRB2 Tclin GABA A receptor alpha-6/beta-2/gamma-2 (27 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GABRB3 Tclin Gamma-aminobutyric acid receptor subunit alpha-6/beta-3 (3 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Associated Targets(non-human)
Gabra4 Gamma-aminobutyric acid receptor subunit alpha-4/beta-3 (9 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Gabrd Gamma-aminobutyric acid receptor subunit alpha-4/beta-3/delta (11 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Gabrg2 Gamma-aminobutyric acid receptor subunit alpha-4/beta-3/gamma-2 (8 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Gabrd Gamma-aminobutyric acid receptor subunit alpha-6/beta-3/delta (24 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Gabrg2 Gamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2 (184 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Gabra6 Gamma-aminobutyric acid receptor subunit alpha-6/beta-2 (5 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Gabrd Gamma-aminobutyric acid receptor subunit alpha-6/beta-2/delta (10 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Gabrg2 Gamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2 (2 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Gabra1 Gamma-aminobutyric acid receptor subunit alpha-1/beta-3 (29 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mechanisms of Action
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Chemical and Physical Properties
SolubilitySoluble in DMSO
Molecular Weight511.600 g/mol
XLogP36.300
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Exact Mass510.858 Da
Monoisotopic Mass508.86 Da
Topological Polar Surface Area74.600 Ų
Heavy Atom Count26
Formal Charge0
Complexity523.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Solution Calculators
Reviews

Customer Reviews

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