GRADE & PURITY 10mM in DMSO

Synonyms

D-Dulcitol | DS-6321 | Dulcitol, puriss. | NSC-1944 | CAS-608-66-2 | DTXCID9026051 | meso-galactitol | Tox21_111644_1 | AC-34851 | G0005 | galactitol | NCGC00159410-03 | WURCS=2.0/1,1,0/[h2112h]/1/ | AI3-19423 | EINECS 210-165-2 | NCGC00159410-04 | NCGC00

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Dulcitol is a sugar alcohol and slightly sweet tastant for human taste cells.
Dulcitol (Galactitol), a sugar alcohol derived through reduction of galatose, is studied to determine its role and mechanisms in pathologies such as cataract formation, hepatosplenomegaly and mental retardation. Galactitol is used as a substrate to identify, differentiate and characterize galactitol dehydrogenase(s).

Specifications

Synonyms

D-Dulcitol | DS-6321 | Dulcitol, puriss. | NSC-1944 | CAS-608-66-2 | DTXCID9026051 | meso-galactitol | Tox21_111644_1 | AC-34851 | G0005 | galactitol | NCGC00159410-03 | WURCS=2.0/1, 1, 0/[h2112h]/1/ | AI3-19423 | EINECS 210-165-2 | NCGC00159410-04 | NCGC00

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

A sugar alcohol and slightly sweet tastant for human taste cells.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

• Canonical Smiles: C(C(C(C(C(CO)O)O)O)O)O
• IUPAC Name: (2R,3S,4R,5S)-hexane-1,2,3,4,5,6-hexol
• InChIKey: FBPFZTCFMRRESA-GUCUJZIJSA-N
• INCHI: 1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5+,6-
• Isomeric SMILES: C([C@H]([C@@H]([C@@H]([C@H](CO)O)O)O)O)O
• WGK Germany: 3
• Molecular Weight: 182.17
• Beilstein: 1721903
• Reaxy-Rn: 8496933
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=8496933&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic oxygen compounds
    • Class Organooxygen compounds
      • Subclass Carbohydrates and carbohydrate conjugates

• Kingdom: Organic compounds
• Superclass: Organic oxygen compounds
• Class: Organooxygen compounds
• Subclass: Carbohydrates and carbohydrate conjugates
• Intermediate Tree Nodes: Not available
• Direct Parent: Sugar alcohols
• Alternative Parents: Monosaccharides Secondary alcohols Polyols Primary alcohols Hydrocarbon derivatives
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: Sugar alcohol - Monosaccharide - Secondary alcohol - Polyol - Hydrocarbon derivative - Primary alcohol - Alcohol - Aliphatic acyclic compound
• Description: This compound belongs to the class of organic compounds known as sugar alcohols. These are hydrogenated forms of carbohydrate in which the carbonyl group (aldehyde or ketone, reducing sugar) has been reduced to a primary or secondary hydroxyl group.
• External Descriptors: hexitol

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

HT-29 (80576 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MCF7 (126967 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

NCI-H460 (60772 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Galc Galactocerebrosidase (11 Activities)

Discover Target: Galc

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CHO-K1 (1115 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Sensitivity: Moisture sensitive
• Boil Point(°C): 275～280°C
• Melt Point(°C): 188-189°C
• Molecular Weight: 182.170 g/mol
• XLogP3: -3.100
• Hydrogen Bond Donor Count: 6
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 5
• Exact Mass: 182.079 Da
• Monoisotopic Mass: 182.079 Da
• Topological Polar Surface Area: 121.000 Ų
• Heavy Atom Count: 12
• Formal Charge: 0
• Complexity: 105.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 4
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

References

1. Shao Xuefeng, Yang Sheng, Chen Chenlin, Fan Liwu, Yu Zitao.  (2021)  Temperature-Dependent Rheological Behaviors of Binary Eutectic Mixtures of Sugar Alcohols for Latent Heat Storage: A Comparative Study with Pure Sugar Alcohols.  Journal of Thermal Science,  30  (6): (2002-2014).  [PMID:] [10.1007/s11630-021-1279-9]

2. Tao Wang, Yang Liu, Rui Meng, Mingfu Zhang.  (2020)  Thermal performance of galactitol/mannitol eutectic mixture/expanded graphite composite as phase change material for thermal energy harvesting.  Journal of Energy Storage,      [PMID:] [10.1016/j.est.2020.101997]

3. Zhongwei Zou, Haiming Xu, Dongya Li, Jingyu Sun, Dongsheng Xia.  (2018)  Facile preparation and photocatalytic activity of oxygen vacancy rich BiOCl with {0 0 1} exposed reactive facets.  APPLIED SURFACE SCIENCE,      [PMID:] [10.1016/j.apsusc.2018.09.025]

4. Xue-Feng Shao, Chao Wang, Yong-Jian Yang, Biao Feng, Zi-Qin Zhu, Wu-Jun Wang, Yi Zeng, Li-Wu Fan.  (2018)  Screening of sugar alcohols and their binary eutectic mixtures as phase change materials for low-to-medium temperature latent heat storage. (Ⅰ): Non-isothermal melting and crystallization behaviors.  ENERGY,      [PMID:] [10.1016/j.energy.2018.07.081]

5. Yongchun Huang, Jie Bai, Jinman Shui, Zhanhai Su, Chengzhu Cao, Haiyan Wang, Qiong Wu, Shoude Zhang.  (2025)  Simultaneous determination of the monosaccharide types and their absolute configurations in polysaccharides based on UPLC-MS/MS.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:39788268] [10.1016/j.ijbiomac.2025.139647]

6. Du Jinjing, Lin Haiyang, Zhai Ruitong, Liu Xun, Cui Xinxin, Wang Dongbo, Wang Bin, Zhu Jun, Tang Wendan, Zuo Heng, Li Qian, He Xihong.  (2025)  Effect of hexanol-based additives on the performance of positive electrolyte for vanadium redox flow battery.  IONICS,      [PMID:] [10.1007/s11581-025-06516-6]

7. Tong Zhang, Fangyuan Sun, Libing Zheng, Dazheng Wang, Yanhui Feng.  (2023)  Study of the effect of phase state on the interfacial thermal conductance between PCMs and ceramic skeletons.  COMPOSITE INTERFACES,      [PMID:] [10.1080/09276440.2023.2210878]

8. Xue-Feng Shao, Sheng Yang, Hong-Yi Shi, Li-Wu Fan, Yan-Ping Yuan.  (2023)  A comprehensive evaluation on the cycling stability of sugar alcohols for medium-temperature latent heat storage.  Journal of Energy Storage,      [PMID:] [10.1016/j.est.2023.107190]

9. Rui Ge, Qikai Su, Jian Liang, Lu Zheng, Qing-shan Li, Li Tang.  (2025)  Dulcitol ameliorates LPS-induced acute lung injury (ALI) in mice by inhibiting TLR4/NF-κB activation.  Journal of Functional Foods,      [PMID:] [10.1016/j.jff.2025.106797]

10. Jie Bai, Yongchun Huang, Yuling Zhao, Lirong Zhang, Fuli Zhu, Yixizhuoma, Yuxin Weng, Shoude Zhang.  (2026)  Determination of the monosaccharide types and absolute configurations in polysaccharides with (S)-(-)-1-phenylethylamine based on UPLC-MS/MS.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:41638272] [10.1016/j.ijbiomac.2026.150674]

11. Shi Cong-Rong, Zhang Xiao-Juan, Xie Han, Zhang Wei, Tang Rui-Xin, Lu Zhen-Ming, Geng Yan, Lu Ran, Wang Fang-Zhou, Chai Li-Juan, Zhang Hui-Ling, Xu Hong-Yu, Shi Jin-Song, Xu Zheng-Hong.  (2026)  Metabolomic profiling of goji fermentation: enhancing functional metabolites with high-glucose-adaptive LAB.  npj Science of Food,      [PMID:] [10.1038/s41538-026-00791-x]