E-7386 - 10mM in DMSO , CAS No.1799824-08-0

CAS: 1799824-08-0 Cat. No.: E656399 Formula: C₃₉H₄₈FN₉O₄ Molecular Weight: 725.85 PubChem CID: 91810345

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

E-7386 is an orally active CBP/beta-catenin modulator.

In Vivo

E-7386 is an orally active CBP/beta-catenin modulator which can induce T cells infiltration into tumor and enhance antitumor activity of anti-PD-1 mAb in Wnt1 tumor syngeneic mice model. E-7386 shows significant antitumor activity in Wnt1 model. Infiltration of T cells is limited in vehicle control group, but T cell infiltration into tumors is clearly observed in E-7386 treatment group . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:CBP/beta-catenin

Specifications

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

E-7386 is an orally active CBP/beta-catenin modulator.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Names and Identifiers

Isomeric SMILES

CCN1CCN(CC1)C2CN(C2)C3=CC=CC(=N3)CN4C[C@H]5N([C@H](C4=O)CC6=C(C=C(C=C6)O)F)C(=O)CN(N5C(=O)NCC7=CC=CC=C7)CC=C

PubChem CID

91810345

Molecular Weight

725.85