Efaproxiral (RSR13) - Moligand™,10mM in DMSO , Hemoglobin HbA negative modulator, CAS No.131179-95-8, Hemoglobin HbA negative modulator

CAS: 131179-95-8 Cat. No.: E656594 Molecular Weight: 341.40

GRADE & PURITY Moligand™, 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Efaproxiral is a haemoglobin (Hb) synthetic allosteric modifier, decreases Hb-oxygen (O2) binding affinity and enhances oxygenation of hypoxic tumours during radiation therapy

In Vitro

Efaproxiral binds to only one pair of symmetry-related sites in the Hb central water cavity. Efaproxiral readily crosses the red cell membrane in the presence of serum albumin solutions. Efaproxiral is not inhibited from entering erythrocytes in the presence of an anion-channel blocking agent (DIDS). MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Efaproxiral (150 mg/kg, i.p.) increase tumor oxygenation，and increase the tumor growth inhibition of radiotherapy over 5 days of treatment. Efaproxiral reduces hemoglobin-oxygen binding affinity, which facilitates oxygen release from hemoglobin into surrounding tissues and potentially increases the pO(2) of the tumorsMCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Female C3H/HEJ mice (18–20 g), with radiation-induced fibrosarcoma tumor (RIF-1) cells xenograftDosage: 150 mg/kg Administration: Intraperitoneal injection; prior to X Irradiation (4 Gy/day), for 5 days Result: Significantly increased tumor oxygenation by 8.4 to 43.4 mmHg within 5 days, with maximum increases at 22–31 minutes after treatment.

IC50& Target:haemoglobin (Hb)

Specifications

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

Efaproxiral is a haemoglobin (Hb) synthetic allosteric modifier, decreases Hb-oxygen (O2) binding affinity and enhances oxygenation of hypoxic tumours during radiation therapy.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

NEGATIVE MODULATOR

Mechanism of action

Hemoglobin HbA negative modulator

Product Properties

• ALogP: 3.6

Names and Identifiers

• Isomeric SMILES: CC1=CC(=CC(=C1)NC(=O)CC2=CC=C(C=C2)OC(C)(C)C(=O)O)C
• Molecular Weight: 341.40

References

1. Zhang Kai, Xin Jiaying, Lu Xuechun.  (2024)  Enhanced triolein and ethyl ferulate interesterification performance by CRL-AuNPs.  BIORESOURCE TECHNOLOGY,      [PMID:38493938] [10.1016/j.biortech.2024.130599]