eIF4A3-IN-18 , CAS No.1402931-84-3

CAS: 1402931-84-3 Cat. No.: E650559 Formula: C₂₉H₂₈N₂O₆ Molecular Weight: 500.54

Storage

Store at 2-8°C,Protected from light,Desiccated

Shipped In

Wet ice

Overview

eIF4A3-IN-18 (compound 74) is a silvestrol analogue. eIF4A3-IN-18 interferes the assembling of eIF4F translation complex with EC 50 values of 0.8, 35 and 2 nM for myc-LUC, tub-LUC and the growth inhibition for MBA-MB-231 cells. eIF4A3-IN-18 also has cytotoxicity to RMPI-8226 cells with an LC 50 of 0.06 nM. eIF4A3-IN-18 can be used for the research of human cancer pathogenesis.

Form:Solid

Specifications

Biochemical and Physiological Mechanisms

eIF4A3-IN-18 (compound 74) is a silvestrol ( HY-13251 ) analogue. eIF4A3-IN-18 interferes the assembling of eIF4F translation complex with EC 50 values of 0.8, 35 and 2 nM for myc-LUC, tub-LUC and the growth inhibition for MBA-MB-231 cells. eIF4A3-IN-18 a

Storage

Store at 2-8°C,Protected from light,Desiccated

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

Canonical Smiles

COC1=CC=C([C@@]23OC4=CC(C#N)=CC(OC)=C4[C@]2(O)[C@@H]([C@@H]([C@H]3C5=CC=CC=C5)C(N(C)C)=O)O)C=C1

Molecular Weight

500.54

Frequently Asked Questions

How should this product be stored?

Store at 2–8 °C, protected from light, desiccated. Keep the container tightly closed with desiccant — the material is moisture-sensitive.

How is this product shipped?

This product ships chilled on wet ice. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1402931-84-3, the molecular formula is C29H28N2O6, and the molecular weight is 500.54 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.