eIF4A3-IN-2 - 10mM in DMSO , CAS No.2095677-20-4

CAS: 2095677-20-4 Cat. No.: E656263 Formula: C₂₅H₁₉Br₂ClN₄O₂ Molecular Weight: 602.70 PubChem CID: 131953885

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

eIF4A3-IN-2 is a highly selective and noncompetitive eukaryotic initiation factor 4A-3 (eIF4A3) inhibitor with an IC 50 of 110 nM

In Vitro

eIF4A3-IN-2 (compound 2) binds to the allosteric region in eIF4A3 and inhibits in vitro ATPase, helicase, and cellular nonsense-mediated RNA decay (NMD) activities. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Apoptosis AnalysisCell Line: HEK293T cells (transfected with the NMD reporter) luciferase assay Concentration: 0.3, 1, 3, or 10 μM Incubation Time: 3 or 6 h Result: eIF4A3-IN-2 induces an approximately 3.2-fold increase in luciferase activity, indicating that NMD is inhibited by compound 2.

IC50& Target:IC50: 110 nM (eIF4A3)

Specifications

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

eIF4A3-IN-2 is a highly selective and noncompetitive eukaryotic initiation factor 4A-3 (eIF4A3) inhibitor with an IC 50 of 110 nM.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

• Isomeric SMILES: C1CN([C@H](CN1C(=O)C2=C3C=CC(=CN3N=C2)Br)C4=CC=C(C=C4)Cl)C(=O)C5=CC=C(C=C5)Br
• PubChem CID: 131953885
• Molecular Weight: 602.70

Associated Targets(Human)

EIF4A3 Tchem Eukaryotic initiation factor 4A-III (3 Activities)

Discover Target: EIF4A3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Frequently Asked Questions

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2095677-20-4, the molecular formula is C25H19Br2ClN4O2, and the molecular weight is 602.70 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.