EL-102 - ≥99% , CAS No.1233948-61-2

CAS: 1233948-61-2 Cat. No.: E651242 Molecular Weight: 384.47 PubChem CID: 62705067

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

EL-102 is a hypoxia-induced factor 1 (Hif1α) inhibitor. EL-102 induces apoptosis , inhibits tubulin polymerisation and shows activities against prostate cancer . EL-102 can be used for the research of cancer

In Vitro

EL-102 (0-120 nM; 72 h) inhibits prostate cancer cells proliferation in vitro. EL-102 (0-100 nM; 72 h) shows cytotoxicity to prostate cancer cell lines. EL-102 (10-100 nM; 24-72 h) induces cellular apoptosis and affects cell cycle. EL-102 (10-100 nM; 24-48 h) affects PARP cleavage in DU145 cells. EL-102 (5 nM; 0-60 min) inhibits tubulin polymerisation activity. EL-102 (0-100 nM; 1 hour) inhibits Hif1α protein expression. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation AssayCell Line: CWR22, 22Rv1, DU145, PC-3, DLKP and DLKPA cell lines Concentration: 0-120 nM Incubation Time: 72 hours Result: Inhibited proliferation of CWR22, 22Rv1, DU145, PC-3, DLKP and doxorubicin-selected variant DLKPA cells with IC 50 s of 24, 21.7, 40.3, 37.0, 14.4 and 16.3 nM, respectively. Cell Cytotoxicity AssayCell Line: CWR22, 22Rv1, DU145 and PC-3 cell lines Concentration: 0-100 nM Incubation Time: 72 hours Result: Exibited cytotoxicity to prostate cancer cell lines, and showed no additive effect on the inhibition of cell viability with docetaxel. Apoptosis AnalysisCell Line: CWR22, 22Rv1, DU145, PC-3, DLKP and DLKPA cell lines Concentration: 10 and 100 nM Incubation Time: 24, 48 and 72 hours Result: Induced cell apoptosis to inhibits cell viability with a dose of 100 nM. Western Blot AnalysisCell Line: DU145 cell line Concentration: 10 and 100 nM Incubation Time: 24 and 48 hours Result: Increased PARP cleavage in DU145 cells and showed a more dramatic effect with docetaxel adding. Cell Cycle AnalysisCell Line: DU145 cell line Concentration: 10 and 100 nM Incubation Time: 24, 48 and 72 hours Result: Increased loss of cells from G1 phase and accumulated cells in G2/M phase. Western Blot AnalysisCell Line: Prostate cancer cells Concentration: 10 , 50 and 100 nM Incubation Time: 24 and 48 hours Result: Modestly inhibited Hif1α expression at doses of 50 and 100 nM in normoxia.

In Vivo

EL-102 (12 and 15 mg/kg; p.o. 5-day on and 2-day off, from 13 to 37 days after tumour transplantation) potentiates effects of docetaxel in vivo . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Nude mice with CWR22 xenografts Dosage: 12 and 15 mg/kg Administration: Oral gavage; 12 and 15 mg/kg 5-day on and 2-day off; from 13 to 37 days after tumour transplantation Result: Showed no effect on tumor growth, but enhanced the effect of docetaxel on tumor .

Form:Solid

IC50& Target:IC50: 24 nM (CWR22), 21.7 nM (22Rv1), 40.3 nM (DU145), 37.0 nM (PC-3), 14.4 nM (DLKP), 16.3 nM (DLKPA)

Specifications

Specifications & Purity

≥99%

Biochemical and Physiological Mechanisms

EL-102 is a hypoxia-induced factor 1 (Hif1α) inhibitor. EL-102 induces apoptosis , inhibits tubulin polymerisation and shows activities against prostate cancer . EL-102 can be used for the research of cancer.

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Purity

≥99%

Names and Identifiers

• Canonical Smiles: CC1=C(C=C(C=C1)C2=CSC(=C2)C#N)NS(=O)(=O)C3=CC=C(C=C3)OC
• IUPAC Name: N-[5-(5-cyanothiophen-3-yl)-2-methylphenyl]-4-methoxybenzenesulfonamide
• InChIKey: STJKZARVVAISJM-UHFFFAOYSA-N
• INCHI: 1S/C19H16N2O3S2/c1-13-3-4-14(15-9-17(11-20)25-12-15)10-19(13)21-26(22,23)18-7-5-16(24-2)6-8-18/h3-10,12,21H,1-2H3
• Isomeric SMILES: CC1=C(C=C(C=C1)C2=CSC(=C2)C#N)NS(=O)(=O)C3=CC=C(C=C3)OC
• PubChem CID: 62705067
• Molecular Weight: 384.47

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Class Benzene and substituted derivatives
      • Subclass Benzenesulfonamides

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Class: Benzene and substituted derivatives
• Subclass: Benzenesulfonamides
• Intermediate Tree Nodes: Not available
• Direct Parent: Benzenesulfonamides
• Alternative Parents: Phenoxy compounds Methoxybenzenes Anisoles Alkyl aryl ethers Thiophenes Sulfonyls Organosulfonic acids and derivatives Heteroaromatic compounds Thioenol ethers Sulfenyl compounds Nitriles Organopnictogen compounds Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Benzenesulfonamide - Phenoxy compound - Methoxybenzene - Phenol ether - Anisole - Alkyl aryl ether - Heteroaromatic compound - Thiophene - Sulfonyl - Organosulfonic acid or derivatives - Organic sulfonic acid or derivatives - Thioenolether - Organoheterocyclic compound - Sulfenyl compound - Nitrile - Carbonitrile - Ether - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organosulfur compound - Organooxygen compound - Organonitrogen compound - Aromatic heteromonocyclic compound
• Description: This compound belongs to the class of organic compounds known as benzenesulfonamides. These are organic compounds containing a sulfonamide group that is S-linked to a benzene ring.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Solubility: DMSO : ≥ 36 mg/mL (93.64 mM)
• Molecular Weight: 384.500 g/mol
• XLogP3: 4.100
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 5
• Exact Mass: 384.06 Da
• Monoisotopic Mass: 384.06 Da
• Topological Polar Surface Area: 116.000 Ų
• Heavy Atom Count: 26
• Formal Charge: 0
• Complexity: 616.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1