EPhos Pd G4 , CAS No.2132978-44-8

CAS: 2132978-44-8 Cat. No.: E486882 Formula: C₅₀H₇₁NO₄PPdS+ Molecular Weight: 919.6 PubChem CID: 138962046

Storage

Room temperature

Overview

Description

Buchwald palladacycle precatalyst with EPhos ligand for Pd-catalyzed C–N cross-coupling between primary amines and aryl halides to form 2-arylaminooxazoles. Catalyst system was reported with NaOPh (CDS001581).It is a fourth generation (G4)Buchwaldprecatalyst that is similar to the third generation (G3) precatalysts except that the amino group on the biphenyl backbone is methylated. This modification helps to prevent the limitations of using the third generation precatalysts. It is air, moisture and thermally-stable and shows good solubility in common organic solvents. BrettPhos Pd G4 is highly useful in cross-coupling reactions. Some of its excellent features include lower catalyst loadings, shorter reaction time, and efficient formation of the active catalytic species and accurate control of ligand: palladium ratio.

Specifications

Storage

Room temperature

Names and Identifiers

• Canonical Smiles: CC(C)C1=CC(=C(C(=C1)C(C)C)C2=C(C(=CC=C2)OC(C)C)[PH+](C3CCCCC3)C4CCCCC4)C(C)C.C[N-]C1=CC=CC=C1C2=CC=CC=[C-]2.CS(=O)(=O)O.[Pd+2]
• IUPAC Name: dicyclohexyl-[2-propan-2-yloxy-6-[2,4,6-tri(propan-2-yl)phenyl]phenyl]phosphanium;methanesulfonic acid;methyl-(2-phenylphenyl)azanide;palladium(2+)
• InChIKey: LRMKRTFHVFDHRY-UHFFFAOYSA-O
• INCHI: 1S/C36H55OP.C13H11N.CH4O3S.Pd/c1-24(2)28-22-32(25(3)4)35(33(23-28)26(5)6)31-20-15-21-34(37-27(7)8)36(31)38(29-16-11-9-12-17-29)30-18-13-10-14-19-30;1-14-13-10-6-5-9-12(13)11-7-3-2-4-8-11;1-5(2,3)4;/h15,20-27,29-30H,9-14,16-19H2,1-8H3;2-7,9-10H,1H3;1H3,(H,2,3,4);/q;-2;;+2/p+1
• PubChem CID: 138962046
• Molecular Weight: 919.6

Chemical and Physical Properties

• Flash Point(°F): Not applicable
• Flash Point(°C): Not applicable