Epiandrosterone - 10mM in DMSO , CAS No.481-29-8

CAS: 481-29-8 Cat. No.: E407759 Molecular Weight: 290.4 EC Number: 207-563-3

GRADE & PURITY 10mM in DMSO

Synonyms

3β-androsterone, EpiA | 3β-Hydroxy-5α-androstane-17-one

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Epiandrosterone Epiandrosterone (3β-androsterone, EpiA) is a steroid hormone with weak androgenic activity, is a natural metabolite of DHEA.
In vitro

Epiandrosterone is a natural metabolite of dehydroepiandrosterone (DHEA) via the 5α-reductaseenzyme. Epiandrosterone is formed in peripheral tissues, from which it is released into the circulation and is ultimately excreted in the urine. Epiandrosterone is only a weak androgen, but it is widely recognized to inhibit the pentosephosphate pathway (PPP) and to decrease intracellular NADPH levels. Epiandrosterone attenuates NO-evoked relaxation of pulmonary artery , although it inhibits angiotensin II- and hypoxia-induced vasoconstriction in isolated lungs and relaxes isolated pulmonary arteries pre-constricted with KCl.

In vivo

Cell Data

cell lines：MES-SA, MDA-MB-468, MCF-7, HCT116, HT29, U87MG, PC-3 and DU145 cells

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyms

3β-androsterone, EpiA | 3β-Hydroxy-5α-androstane-17-one

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Epiandrosterone (3β-androsterone, EpiA) is a steroid hormone with weak androgenic activity, is a natural metabolite of DHEA.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

• Isomeric SMILES: C[C@]12CC[C@@H](C[C@@H]1CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CCC4=O)C)O
• Molecular Weight: 290.4
• Reaxy-Rn: 2055720
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2055720&ln=

References

1. Bairen Du, Jingjing Zhang, Yanjie Dong, Junwei Wang, Longwen Lei, Rengfei Shi.  (2020)  Determination of testosterone/epitestosterone concentration ratio in human urine by capillary electrophoresis.  STEROIDS,      [PMID:32603755] [10.1016/j.steroids.2020.108691]