Ethyl 3,4-Dihydroxycinnamate - ≥97% , CAS No.66648-50-8

Name: Ethyl 3,4-Dihydroxycinnamate - ≥97% , CAS No.66648-50-8
Brand: Aladdin Scientific
SKU: E341244
Availability: InStock

CAS: 66648-50-8 Cat. No.: E341244 Molecular Weight: 208.2 EC Number: 676-772-3

COA

Skip to the end of the images gallery

Ethyl 3,4-Dihydroxycinnamate - ≥97% CAS No(66648-50-8) by Aladdin Scientific

Skip to the beginning of the images gallery

AVAILABLE TO ORDER

GRADE & PURITY ≥97%

Synonyms

4gqq | NSC619661 | NSC-619661 | ethyl 3-(3,4-dihydroxyphenyl)prop-2-enoate | (E)-ethyl caffeate | AC-34380 | HY-N6966 | 2-oxo-3-(phosphonooxy)-Propanoic acid | Caffeic acid ethyl ester | DTXSID201336725 | (E)-Ethyl Dihydroxycinnamate | 3-(3,4-Dihydroxy-ph

Storage

Protected from light,Store at -20°C

Shipped In

Ice chest + Ice pads

Size

Status

Price

Qty

250mg

E341244-250mg

8-12 wks(?)

$15.90

E341244-1g

8-12 wks(?)

$24.90

$39.90
Save $15.00 (37.59%)

E341244-5g

8-12 wks(?)

$85.90

$129.90
Save $44.00 (33.87%)

25g

E341244-25g

8-12 wks(?)

$328.90

$399.90
Save $71.00 (17.75%)

Enter a quantity for the sizes you want to add.

Bulk / Custom

♡ Wish List ⇅ Compare ⎙ Print page

Overview Specifications Product Properties Names and Identifiers Documentation Advanced Data Taxonomic Classification 3D Structure Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Solution Calculators Reviews

🧪

Why this grade

≥97% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Protected from light,Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

Ethyl 3,4-Dihydroxycinnamate is an ethyl ester resulting from the formal condensation of the carboxy group of trans-caffeic acid with ethanol.Natural product derived from plant source.

Ethyl 3,4-dihydroxycinnamate shows anti-inflammatory, immunomodulatory, and anti-carcinogenic properties. It is a potent and specific inhibitor of NF-κB and its downstream inflammatory mediators: NOS2 (inducible nitric oxide synthase; NOS; NOS II), Cox-2 (cyclooxygenase-2), and prostaglandin E2 (PGE2). Ethyl 3,4-Dihydroxycinnamate prevents DNA single-strand breaks caused by H2O2.

Application

Used for compound screening libraries, metabolomics, phytochemistry, and drug research.

Specifications

Synonyms

4gqq | NSC619661 | NSC-619661 | ethyl 3-(3, 4-dihydroxyphenyl)prop-2-enoate | (E)-ethyl caffeate | AC-34380 | HY-N6966 | 2-oxo-3-(phosphonooxy)-Propanoic acid | Caffeic acid ethyl ester | DTXSID201336725 | (E)-Ethyl Dihydroxycinnamate | 3-(3, 4-Dihydroxy-ph

Specifications & Purity

≥97%

Biochemical and Physiological Mechanisms

Ethyl dihydroxycinnamate exhibits potent cytotoxicity, inhibits COX-2 and P-hydroxybenzoic acid, both involved in inflammation and cytokine synthesis. It demonstrates antibacterial efficacy against MRSA and Bacillus subtilis and inhibits cancer cell growt

Storage

Protected from light, Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥97%

Product Properties

pKa	pKₐ: 8.71 (Predicted)

Names and Identifiers

Canonical Smiles	CCOC(=O)C=CC1=CC(=C(C=C1)O)O
IUPAC Name	ethyl (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate
InChIKey	WDKYDMULARNCIS-GQCTYLIASA-N
INCHI	1S/C11H12O4/c1-2-15-11(14)6-4-8-3-5-9(12)10(13)7-8/h3-7,12-13H,2H2,1H3/b6-4+
Isomeric SMILES	CCOC(=O)/C=C/C1=CC(=C(C=C1)O)O
Molecular Weight	208.2
Reaxy-Rn	2646303
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2646303&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Phenylpropanoids and polyketides
  - Class Cinnamic acids and derivatives
    - Subclass Hydroxycinnamic acids and derivatives

Kingdom	Organic compounds
Superclass	Phenylpropanoids and polyketides
Class	Cinnamic acids and derivatives
Subclass	Hydroxycinnamic acids and derivatives
Intermediate Tree Nodes	Not available
Direct Parent	Coumaric acids and derivatives
Alternative Parents	Cinnamic acid esters Styrenes Catechols Fatty acid esters 1-hydroxy-4-unsubstituted benzenoids 1-hydroxy-2-unsubstituted benzenoids Enoate esters Monocarboxylic acids and derivatives Organic oxides Hydrocarbon derivatives Carbonyl compounds
Molecular Framework	Aromatic homomonocyclic compounds
Substituents	Coumaric acid or derivatives - Cinnamic acid ester - Catechol - Styrene - 1-hydroxy-4-unsubstituted benzenoid - 1-hydroxy-2-unsubstituted benzenoid - Phenol - Fatty acid ester - Fatty acyl - Benzenoid - Monocyclic benzene moiety - Alpha,beta-unsaturated carboxylic ester - Enoate ester - Carboxylic acid ester - Carboxylic acid derivative - Monocarboxylic acid or derivatives - Organooxygen compound - Hydrocarbon derivative - Organic oxygen compound - Carbonyl group - Organic oxide - Aromatic homomonocyclic compound
Description	This compound belongs to the class of organic compounds known as coumaric acids and derivatives. These are aromatic compounds containing Aromatic compounds containing a cinnamic acid moiety (or a derivative thereof) hydroxylated at the C2 (ortho-), C3 (meta-), or C4 (para-) carbon atom of the benzene ring.
External Descriptors	hydroxycinnamic acid
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

3D Structure

Associated Targets(Human)

ALOX5 Tclin Arachidonate 5-lipoxygenase (6568 Activities)

Discover Target: ALOX5

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

BeWo (124 Activities)

Lot Number	Certificate Type	Date	Item
B2604219	Certificate of Analysis	Jan 16, 2026	E341244
B2604220	Certificate of Analysis	Jan 16, 2026	E341244
B2604221	Certificate of Analysis	Jan 16, 2026	E341244
B2604224	Certificate of Analysis	Jan 16, 2026	E341244

Sensitivity	light sensitive
Refractive Index	n20D1.61 (Predicted)
Boil Point(°C)	376.98° C at 760 mmHg (Predicted)
Melt Point(°C)	142.0°C-148.0°C
Molecular Weight	208.210 g/mol
XLogP3	2.600
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	4
Exact Mass	208.074 Da
Monoisotopic Mass	208.074 Da
Topological Polar Surface Area	66.800 Å²
Heavy Atom Count	15
Formal Charge	0
Complexity	237.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	1
Covalently-Bonded Unit Count	1

Ethyl 3,4-Dihydroxycinnamate - ≥97% , CAS No.66648-50-8

Why this grade

Storage & shipping

Quality documents

Literature proof

Overview

Specifications

Documentation

📋 Safety Data Sheet (SDS)

✅ Certificate of Analysis (COA)

📊 Datasheet

🔬 Specification Sheet

Advanced Data

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

Customer Reviews

View related series