≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at 2-8°C Ships Wet ice Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 4 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
application：
Ethyl 3-Hydroxybutyrate is a useful synthetic intermediate. It is a reagent used to synthesize α-azido carboxylic acids. It is also used in Palladium mediated spiroketal synthesis.
| Pubchem Sid | 504753855 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504753855 |
| Canonical Smiles | CCOC(=O)CC(C)O |
| IUPAC Name | ethyl 3-hydroxybutanoate |
| InChIKey | OMSUIQOIVADKIM-UHFFFAOYSA-N |
| INCHI | 1S/C6H12O3/c1-3-9-6(8)4-5(2)7/h5,7H,3-4H2,1-2H3 |
| Isomeric SMILES | CCOC(=O)CC(C)O |
| WGK Germany | 3 |
| UN Number | 1993 |
| Packing Group | I |
| Molecular Weight | 132.16 |
| Beilstein | 1446190 |
| Reaxy-Rn | 1446190 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1446190&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organic acids and derivatives |
| Class | Hydroxy acids and derivatives |
| Subclass | Beta hydroxy acids and derivatives |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Beta hydroxy acids and derivatives |
| Alternative Parents | Fatty acid esters Secondary alcohols Carboxylic acid esters Monocarboxylic acids and derivatives Organic oxides Hydrocarbon derivatives Carbonyl compounds |
| Molecular Framework | Aliphatic acyclic compounds |
| Substituents | Fatty acid ester - Beta-hydroxy acid - Fatty acyl - Secondary alcohol - Carboxylic acid ester - Monocarboxylic acid or derivatives - Carboxylic acid derivative - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Carbonyl group - Alcohol - Aliphatic acyclic compound |
| Description | This compound belongs to the class of organic compounds known as beta hydroxy acids and derivatives. These are compounds containing a carboxylic acid substituted with a hydroxyl group on the C3 carbon atom. |
| External Descriptors | fatty acid ethyl ester |
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 I2123213 | Certificate of Analysis | Jul 10, 2025 | E101452 |
| I2123332 | Certificate of Analysis | Jul 10, 2025 | E101452 |
| I2123337 | Certificate of Analysis | Jul 10, 2025 | E101452 |
| I2123355 | Certificate of Analysis | Jul 10, 2025 | E101452 |
| E1711024 | Certificate of Analysis | Jan 20, 2025 | E101452 |
| L2502408 | Certificate of Analysis | Jun 27, 2024 | E101452 |
| L2502409 | Certificate of Analysis | Jun 27, 2024 | E101452 |
| L2502413 | Certificate of Analysis | Jun 27, 2024 | E101452 |
| L2502414 | Certificate of Analysis | Jun 27, 2024 | E101452 |
| E2409042 | Certificate of Analysis | Aug 07, 2021 | E101452 |
| L2417356 | Certificate of Analysis | Aug 07, 2021 | E101452 |
| Solubility | Slightly soluble in chloroform and methanol |
|---|---|
| Refractive Index | 1.42 |
| Flash Point(°F) | 170.6 °F |
| Flash Point(°C) | 64 °C |
| Boil Point(°C) | 170°C |
| Molecular Weight | 132.160 g/mol |
| XLogP3 | 0.200 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 4 |
| Exact Mass | 132.079 Da |
| Monoisotopic Mass | 132.079 Da |
| Topological Polar Surface Area | 46.500 Ų |
| Heavy Atom Count | 9 |
| Formal Charge | 0 |
| Complexity | 90.300 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 1 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
| 1. Jun Li, Pu Wang, Yu-Shu He, Zhi-Ren Zhu, Jin Huang. (2018) Toward Designing a Novel Oligopeptide-Based Deep Eutectic Solvent: Applied in Biocatalytic Reduction. ACS Sustainable Chemistry & Engineering, [PMID:] [10.1021/acssuschemeng.8b04989] |
| 2. Yilong Wang, Yongkai Xu, Yun Zhang, Aijun Sun, Yunfeng Hu. (2018) Functional characterization of salt-tolerant microbial esterase WDEst17 and its use in the generation of optically pure ethyl (R)-3-hydroxybutyrate. CHIRALITY, 30 (6): (769-776). [PMID:29573466] [10.1002/chir.22847] |
| 3. Wang Yilong, Zhang Yun, Hu Yunfeng. (2016) Functional Characterization of a Robust Marine Microbial Esterase and Its Utilization in the Stereo-Selective Preparation of Ethyl (S)-3-Hydroxybutyrate. APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, 180 (6): (1196-1212). [PMID:27299920] [10.1007/s12010-016-2161-1] |
| 4. Luyang Zhang, Ziran Wang, Zaiyu Zhang, Yuting Huang, Zhongjing Ren, Haipeng Wang, Wu Duan, Chaqi Gai, Chen Wang, Yang Zhang, Bomi Gweon, Rui You, Peng Yan. (2025) A Multiplexed and In Situ Self-Calibration Biosensor Integrated System for Metabolic Health Analysis in Human Urine. ADVANCED FUNCTIONAL MATERIALS, [PMID:] [10.1002/adfm.202520270] |
