Etomoxir - Moligand™, ≥98% , CAS No.124083-20-1

CAS: 124083-20-1 Cat. No.: E124862 Molecular Weight: 326.82

GRADE & PURITY Moligand™, ≥98%

Synonyms

ETOMOXIR [WHO-DD] | HY-50202 | STK709190 | DTXSID801025772 | Etomoxir [INN] | AC-32627 | (R)-(+)-Etomoxir | 2-OXIRANECARBOXYLIC ACID, 2-(6-(4-CHLOROPHENOXY)HEXYL)-, ETHYL ESTER, (2R)- | CHEBI:95011 | NCGC00378789-04 | BDBM50237625 | UNII-MSB3DD2XP6 | GTPL

Storage

Protected from light,Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Overview

Etomoxir is a cell-permeable, irreversible, and stereospecific inhibitor of carnitine palmitoyltransferase (CPT)-1 and DGAT activity in the mitochondria of rat heart H9c2 myoblastic cells at a concentration of 1-80 μM and 40 μM, respectively.

Specifications

Synonyms

ETOMOXIR [WHO-DD] | HY-50202 | STK709190 | DTXSID801025772 | Etomoxir [INN] | AC-32627 | (R)-(+)-Etomoxir | 2-OXIRANECARBOXYLIC ACID, 2-(6-(4-CHLOROPHENOXY)HEXYL)-, ETHYL ESTER, (2R)- | CHEBI:95011 | NCGC00378789-04 | BDBM50237625 | UNII-MSB3DD2XP6 | GTPL

Specifications & Purity

Moligand™, ≥98%

Biochemical and Physiological Mechanisms

An inhibitor of carnitine palmitoyltransferase A (CPT1), which is required for the oxidation of long-chain acyl CoA esters. Also a strong inhibitor of mitochondrial CPT1 and a candidate as an anti-diabetic drug.CPT1 inhibitor. Inhibits β-oxidation in mito

Storage

Protected from light, Store at -20°C, Argon charged

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥98%

Names and Identifiers

• Pubchem Sid: 504764958
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504764958
• Canonical Smiles: CCOC(=O)C1(CO1)CCCCCCOC2=CC=C(C=C2)Cl
• IUPAC Name: ethyl (2R)-2-[6-(4-chlorophenoxy)hexyl]oxirane-2-carboxylate
• InChIKey: DZLOHEOHWICNIL-QGZVFWFLSA-N
• INCHI: 1S/C17H23ClO4/c1-2-20-16(19)17(13-22-17)11-5-3-4-6-12-21-15-9-7-14(18)8-10-15/h7-10H,2-6,11-13H2,1H3/t17-/m1/s1
• Isomeric SMILES: CCOC(=O)[C@]1(CO1)CCCCCCOC2=CC=C(C=C2)Cl
• Molecular Weight: 326.82
• Reaxy-Rn: 8273691
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=8273691&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Class Phenol ethers

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Class: Phenol ethers
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Phenol ethers
• Alternative Parents: Phenoxy compounds Fatty acid esters Chlorobenzenes Alkyl aryl ethers Oxirane carboxylic acids Aryl chlorides Carboxylic acid esters Oxacyclic compounds Monocarboxylic acids and derivatives Dialkyl ethers Organochlorides Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Phenoxy compound - Phenol ether - Alkyl aryl ether - Chlorobenzene - Fatty acid ester - Halobenzene - Aryl chloride - Aryl halide - Monocyclic benzene moiety - Fatty acyl - Oxirane carboxylic acid or derivatives - Oxirane carboxylic acid - Carboxylic acid ester - Oxacycle - Carboxylic acid derivative - Organoheterocyclic compound - Dialkyl ether - Oxirane - Ether - Monocarboxylic acid or derivatives - Organic oxide - Organooxygen compound - Hydrocarbon derivative - Organic oxygen compound - Carbonyl group - Organochloride - Organohalogen compound - Aromatic heteromonocyclic compound
• Description: This compound belongs to the class of organic compounds known as phenol ethers. These are aromatic compounds containing an ether group substituted with a benzene ring.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

KB (17409 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ABCB11 Tchem Bile salt export pump (2311 Activities)

Discover Target: ABCB11

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Sus scrofa (849 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Solubility: Soluble in Chloroform, Ethyl Acetate
• Sensitivity: Light sensitive
• Molecular Weight: 326.800 g/mol
• XLogP3: 4.300
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 11
• Exact Mass: 326.128 Da
• Monoisotopic Mass: 326.128 Da
• Topological Polar Surface Area: 48.100 Ų
• Heavy Atom Count: 22
• Formal Charge: 0
• Complexity: 342.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 1
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

References

1. Cui Tang, Hui Wang, Lina Guo, Chan Zou, Jianming Hu, Hanyong Zhang, Wenhu Zhou, Guoping Yang.  (2023)  CpG-Conjugated Silver Nanoparticles as a Multifunctional Nanomedicine to Promote Macrophage Efferocytosis and Repolarization for Atherosclerosis Therapy.  ACS Applied Materials & Interfaces,      [PMID:37910772] [10.1021/acsami.3c11227]

2. Lingxiang Ran, Qiu Chen, Xingyu Lu, Zhixiang Gao, Fengmei Cui, Xiaolong Liu, Boxin Xue.  (2023)  Novel treatment and insight for irradiation-induced injuries: Dibucaine ameliorates irradiation-induced testicular injury by inhibiting fatty acid oxidation in primary Leydig cells.  BIOMEDICINE & PHARMACOTHERAPY,      [PMID:37224756] [10.1016/j.biopha.2023.114903]

3. Jin Nan, Bi Aiwei, Lan Xiaojing, Xu Jun, Wang Xiaomin, Liu Yingluo, Wang Ting, Tang Shuai, Zeng Hanlin, Chen Ziqi, Tan Minjia, Ai Jing, Xie Hua, Zhang Tao, Liu Dandan, Huang Ruimin, Song Yue, Leung Elaine Lai-Han, Yao Xiaojun, Ding Jian, Geng Meiyu, Lin Shu-Hai, Huang Min.  (2019)  Identification of metabolic vulnerabilities of receptor tyrosine kinases-driven cancer.  Nature Communications,  10  (1): (1-15).  [PMID:31221965] [10.1038/s41467-019-10427-2]

4. Jiao Shihong, Tang Binghua, Wang Yong, Li Chun, Zeng Zifan, Cui Lixia, Zhang Xuefeng, Shao Mingyan, Guo Dongqing, Wang Qiyan.  (2018)  Pro-angiogenic Role of Danqi Pill Through Activating Fatty Acids Oxidation Pathway Against Coronary Artery Disease.  Frontiers in Pharmacology,      [PMID:30564122] [10.3389/fphar.2018.01414]

5. Jing Wang, Nuli Xie, Shan Lu, Bo Xiao, Yangqin Ou, Qingnian Li, Dexian Liu, Wenhu Zhou.  (2024)  CpG and Rutin Co-Loaded DNA Tetrahedra for Targeted Therapy of Intracerebral Hemorrhage: Synergistic Hematoma Clearance and Neuroinflammation Inhibition.  ADVANCED FUNCTIONAL MATERIALS,      [PMID:] [10.1002/adfm.202403469]

6. Xiangying Zou, Jiayu Jia, Tengfei Zhu, Shouping Cai, Yiman He, Shunde Su, Yu Fang, Jian Li, Guifang Lin, Jun Su.  (2024)  Identification of pine wood nematode (Bursaphelenchus xylophilus) loading response genes in Japanese pine sawyer (Monochamus alternatus) through comparative genomics and transcriptomics.  PEST MANAGEMENT SCIENCE,      [PMID:38511764] [10.1002/ps.8090]

7. Zhonghua Dong, Xiao Li, Xuan Wang, Jingya Xu, Wei Xu.  (2025)  Ergosterol from Edible Fungi: Enhancing Fatty Acid Oxidation via CPT1A to Protect Against Diabetic Kidney Disease.  Food & Function,      [PMID:40704985] [10.1039/D5FO00371G]

8. Kefan Zheng, Hongdi Cui, Ziheng Tang, Entong Song, Qingran Kong, Jiaming Zhang, Hao Li, Qi Zhao.  (2025)  Long-chain fatty acid β-oxidation regulates embryonic development by H3K18 acetylation in mice.  Frontiers in Cell and Developmental Biology,      [PMID:41415208] [10.3389/fcell.2025.1683028]

9. Li Yuan, Han Dongyang, Liu Junjie, Qiao Yuxin, Wei Jiaoxia, Lu Haitao, Yao Li.  (2026)  A novel role for decadienyl-L-carnitine in pulmonary vascular remodeling and the underlying interventional mechanism of osthole.  Chinese Medicine,  21  (1): (87).  [PMID:41840734] [10.1186/s13020-026-01362-8]