Exendin (5-39) is a potent Glukagon-like peptide 1 ( GLP-1 ) receptor antagonist. Exendin (5-39) improves memory impairment in β-amyloid protein-treated rats
In Vivo
Exendin (5-39) (intracerebroventricular injection; 0.3 μg; once daily; 1-week) increases GLT-1 protein levels in the hippocampus of male Wistar rats. Additionally, hippocampal slices are prepared from Ex-treated or vehicle rats,Exendin (5-39) decreases fEPSP decay time and increases the input-output relation and decreased the paired-pulse ratio in the dentate gyrus (DG). Furthermore, Ex inhibits long-term depression but not long-term potentiation in the DG . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Wistar rats (3 weeks old and 18 days pregnant) Dosage: 0.3 μg Administration: Intracerebroventricular injection; 0.3 μg; once daily; 1-week Result: Inhibited GLT-1 protein levels and inhibited long-term depression in rats.
Form:Solid
IC50& Target:IC50: GLP-1 receptor
Specifications
Specifications & Purity
≥99%
Biochemical and Physiological Mechanisms
Exendin (5-39) is a potent Glukagon-like peptide 1 ( GLP-1 ) receptor antagonist. Exendin (5-39) improves memory impairment in β-amyloid protein-treated rats.
Storage
Protected from light,Argon charged,Desiccated,Store at -80°C
Shipped In
Dry ice packs + Cold packs
This product requires cold chain shipping. Ground and other economy services are not available.
Action Type
ANTAGONIST
Purity
≥99%
Names and Identifiers
Molecular Weight
3806.30
Advanced Data
Certificates (CoA,COO,BSE/TSE and Analysis Chart)
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