Isocitrate dehydrogenase (IDH) is a key enzyme family involved in the tricarboxylic acid cycle, NADPH supply, α-ketoglutarate generation, and cellular redox homeostasis. In mammalian cells, the major isoenzymes include IDH1, IDH2, and IDH3. IDH1 and IDH2 are NADP⁺-dependent enzymes and are ...
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