Organofluorine heterocycles are organic compounds that simultaneously contain an organofluorine structural unit and a heterocyclic scaffold. In the same molecule, these two structural factors often work in combination: the heterocycle provides recognition sites, electronic features, and scaffold ...
In drug discovery, many molecules end up stuck in the same awkward spot: potency is good, but exposure is insufficient; selectivity looks fine, but metabolism is too fast; in vitro is beautiful, yet in vivo distribution is disappointing. In those moments, you usually don’t want to rebuild the ...
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