Articles by Topic "MAPK"

1. Macrophage CCR5 Pathway: Chemotactic Signaling, Inflammatory Regulation, and Roles in Disease Microenvironments
   posted this at Jun 21, 2026

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   CCR5 is one of the important chemokine receptors in macrophages. It primarily recognizes CC chemokines such as CCL3, CCL4, and CCL5, and regulates macrophage recruitment, migration, inflammatory cytokine release, phagocytic function, and tissue microenvironment remodeling through G ...
2. TNF Signaling Pathway: Receptor Layering Structure, Complex Conversion Mechanisms, and the Inflammation–Death Effector Network
   posted this at May 13, 2026

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   The TNF signaling pathway is one of the most central signaling networks in inflammatory responses, cell fate regulation, and tissue homeostasis maintenance. Its complexity is not reflected in the single fact that TNF can induce inflammation, but in that the same ligand stimulus can, under ...
3. RANK Signaling Pathway: Molecular Components, Activation Mechanisms, and Biological Effects
   posted this at Apr 28, 2026

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   The RANK signaling pathway is an important component of the TNF receptor superfamily signaling network, with a core axis composed of RANKL, RANK, and OPG.
4. VEGF Signaling Pathway: Receptor Lineage, Activation Mechanisms, and Biological Effects
   posted this at Apr 28, 2026

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   The VEGF (vascular endothelial growth factor) signaling pathway is one of the central molecular networks in angiogenesis research. Its role is not limited to promoting endothelial cell proliferation.