Articles by Topic "Spiral ring skeleton"

1. Rationale for Applying Spirocyclic Building Blocks in Drug Molecule Optimization: Three-Dimensionalization, Conformational Control, and Property Trade-offs
   posted this at Jul 20, 2026

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   In the early stages of drug discovery, researchers usually focus first on activity: whether a compound can bind to the target, inhibit enzymatic activity, or produce the desired effect at the cellular level. However, as a project enters lead optimization, the factors that limit further ...