PARP inhibitors
Poly (ADP-ribose) polymerase (PARP) inhibitors represent a class of therapeutic agents employed in the management of cancer, neurodegenerative disorders, and cardiovascular diseases.
Topic: treat tumors
Articles by Topic "treat tumors"
Knowledge Base
Pim Kinase Inhibitors
Pim kinases are a family of serine/threonine kinases that play critical roles in regulating cell cycle progression and programmed cell death (apoptosis). Two major isoforms have been identified—Pim-1 and Pim-2—both of which are expressed in lymphoid cells and are essential for ...
Paclitaxel
paclitaxel was first identified in 1971 as a potent anticancer compound. Originally isolated from the bark of the Pacific yew tree (Taxus brevifolia Nutt.), it has since been produced through synthetic and semi-synthetic approaches, ensuring broader accessibility for clinical and research use.
Papain and its application
Papain is an enzyme with a protein hydrolytic function and cysteine protease activity. The enzyme belongs to a superfamily that consists of a single polypeptide chain containing three disulfide bonds and a sulfhydryl group essential for enzymatic activity and is derived from the green papaya， ...
JAK-STAT Cell Signaling Pathway
The Janus kinase (JAK) signal transduction and transcriptional activator (STAT) pathway plays a key role in the signaling of a large number of cytokines and growth factors. These cytokines and growth factors are responsible for a variety of cellular functions, including proliferation, growth, ...