Why does nitrobenzene not undergo the Friedel-Crafts acylation reaction?
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Why does nitrobenzene not undergo the Friedel-Crafts acylation reaction?
·Reviewed·Published ·Updated ·8 min read
Why does nitrobenzene not undergo the Friedel-Crafts acylation reaction?
Because the nitro group on nitrobenzene belongs to a strong passivation group, which has electron absorption induction and conjugation effects, and the density of the π electron cloud on the benzene ring decreases, the Friedel-Crafts acylation reaction will not occur.
Da — when not otherwise indicated, molecular weight units are daltons. Mw — weight-average molecular weight. Mn — number-average molecular weight.
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Aladdin Scientific. "Why does nitrobenzene not undergo the Friedel-Crafts acylation reaction?" Aladdin Knowledge Base, updated Oct 9, 2023. https://www.aladdinsci.com/us_en/faqs/why-does-nitrobenzene-not-undergo-the-friedel-crafts-acylation-reaction-en.html
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