10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
Fatostatin (125B11) HBr Fatostatin HBr (Fatostatin A, 125B11) is an inhibitor of sterol regulatory element binding protein (SREBP) . It impairs the activation of SREBP-1 and SREBP-2.
In vitro
Fatostatin inhibits the insulin-induced adipogenesis of 3T3-L1 cells and the serum-independent growth of human androgen-independent prostate cancer (DU145) cells. Fatostatin blocks the activation of SREBPs in cells in tissue culture. Fatostatin suppresses cell proliferation and anchorage-independent colony formation in both androgen-responsive LNCaP and androgen-insensitive C4-2B prostate cancer cells. Fatostatin also reduced in vitro invasion and migration in both cell lines. Further, fatostatin causes G2/M cell cycle arrest and induces apoptosis by increasing caspase-3/7 activity and the cleavages of caspase-3 and PARP.
In vivo
Fatostatin blocks increases in body weight, blood glucose, and hepatic fat accumulation in obese ob/ob mice, even under uncontrolled food intake. Fatostatin significantly inhibits subcutaneous C4-2B tumor growth and markedly decreases serum PSA level compared to the control group.
Cell Data
cell lines：
Concentrations：20 μM
Incubation Time：20 h
Powder Purity:≥99%
| Isomeric SMILES | CCCC1=NC=CC(=C1)C2=NC(=CS2)C3=CC=C(C=C3)C.Br |
|---|---|
| WGK Germany | 1 |
| Molecular Weight | 375.33 |
| Reaxy-Rn | 18508014 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=18508014&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
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| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 F2419027 | Certificate of Analysis | May 13, 2026 | F408346 |
