Fisetin - Moligand™, 10mM in DMSO , CAS No.528-48-3

CAS: 528-48-3 Cat. No.: F409163 Molecular Weight: 286.24 Beilstein Registry Number: 18221 EC Number: 208-434-4
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GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
Synonyms
4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-
Storage
Store at -80°C
Shipped In
Dry ice packs + Cold packs
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Size
Status
Price
Qty
1ml
F409163-1ml
2
$89.90
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Why this grade

Moligand™, 10mM in DMSO Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 33 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

Information

Fisetin Fisetin (Fustel) is a potent sirtuin activating compound (STAC) and an agent that modulates sirtuins .
In vitro


In vivo


Cell Data

cell lines:

Concentrations:

Incubation Time:

Powder Purity:≥95%

Specifications

Synonyms
4H-1-Benzopyran-4-one, 2-(3, 4-dihydroxyphenyl)-3, 7-dihydroxy-
Specifications & Purity
Moligand™, 10mM in DMSO
Biochemical and Physiological Mechanisms
Fisetin (Fustel) is a potent sirtuin activating compound (STAC) and an agent that modulates sirtuins.
Storage
Store at -80°C
Shipped In
Dry ice packs + Cold packs
This product requires cold chain shipping. Ground and other economy services are not available.
Grade
Moligand™
Names and Identifiers
Isomeric SMILES C1=CC(=C(C=C1C2=C(C(=O)C3=C(O2)C=C(C=C3)O)O)O)O
RTECS LK9250000
Alternate CAS 1174865-69-0
Molecular Weight 286.24
Beilstein 18221
Reaxy-Rn 292829
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=292829&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Associated Targets(Human)
ALOX12 Tchem Arachidonate 12-lipoxygenase, 12S-type (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ACHE Tclin Acetylcholinesterase (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

1 results found

Lot NumberCertificate TypeDateItem
G2409585Certificate of AnalysisMay 09, 2026 F409163
Chemical and Physical Properties
Melt Point(°C)330°C
Documents & Articles
Citations of This Product
References
1. Nayun Kim, Junhye Kwon, Ui Sup Shin, Joohee Jung.  (2023)  Fisetin induces the upregulation of AKAP12 mRNA and anti-angiogenesis in a patient-derived organoid xenograft model.  BIOMEDICINE & PHARMACOTHERAPY,      [PMID:37801904] [10.1016/j.biopha.2023.115613]
2. Fangjie Han, Shulin Luo, Zhifang Wu, Zhishan Liang, Wenxin Yang, Dongxue Han, Zhonghui Sun, Zhenbang Liu, Li Niu.  (2023)  A label-free photoelectrochemical sensor based on BiVO4@graphene oxide hybrid for analysis of the antioxidant capacity in food.  JOURNAL OF ELECTROANALYTICAL CHEMISTRY,      [PMID:] [10.1016/j.jelechem.2023.117713]
3. Yufeng Chen, Guobin Xia, Chunfeng Wang, Huawei Wu, Xiaogang Xu, Genxiang Mao, Jiong Wu, Zhenlei Zhao.  (2023)  Impact of dietary plant flavonoids on 7,8-dihydroxyflavone transepithelial transport in human intestinal Caco-2 cells.  Food Science & Nutrition,      [PMID:37970375] [10.1002/fsn3.3581]
4. Xiao-Hua Zhang, Xiang-Dong Qing, Jing-Jing Zheng, Yan Yu, Jiaojiao Huang, Chao Kang, Zhi Liu.  (2023)  Aqueous two-phase systems coupled with chemometrics-enhanced HPLC-DAD for simultaneous extraction and determination of flavonoids in honey.  Food Chemistry-X,      [PMID:37780266] [10.1016/j.fochx.2023.100766]
5. Sichao Gu, Xuefeng Zhou, Xingshi Yuan, Yunliang Zhu, Hui Zhang, Lei Xu, Li Li.  (2023)  Photocurable fisetin silk fibroin hydrogel accelerates infected diabetic wounds healing through biofilm inhibition and macrophage immunomodulation.  MATERIALS LETTERS,      [PMID:] [10.1016/j.matlet.2023.134154]
6. Ruiyi Fan, Congyi Zhu, Diyang Qiu, Genlin Mao, Bernd Mueller-Roeber, Jiwu Zeng.  (2023)  Integrated transcriptomic and metabolomic analyses reveal key genes controlling flavonoid biosynthesis in Citrus grandis ‘Tomentosa’ fruits.  PLANT PHYSIOLOGY AND BIOCHEMISTRY,      [PMID:36724705] [10.1016/j.plaphy.2023.01.050]
7. Chun Xiao Li, Fu Rong Wang, Bing Zhang, Ze Yuan Deng, Hong Yan Li.  (2023)  Stability and antioxidant activity of phenolic compounds during in vitro digestion.  JOURNAL OF FOOD SCIENCE,  88  (2): (696-716).  [PMID:36617678] [10.1111/1750-3841.16440]
8. Hongting Deng, Yuanju He, Hui Cao, Lei Chen, Hui Teng.  (2022)  New insight into the effect of hydroxyl substituted flavonoids on the cytotoxicity of 2-amino-3-methylimidazo[4,5-f]quinoline.  Food Frontiers,  (1): (289-296).  [PMID:] [10.1002/fft2.194]
9. Wenjie Yu, Fengjie Sun, Ruixin Xu, Meng Cui, Yongquan Liu, Quanyuan Xie, Limin Guo, Chenxian Kong, Xin Li, Xiali Guo, Liping Luo.  (2022)  Chemical composition and anti-inflammatory activities of Castanopsis honey.  Food & Function,  14  (1): (250-261).  [PMID:36484340] [10.1039/D2FO02233H]
10. Xiaochong Song, Qing Luo, Xiaojia Huang.  (2022)  Speciation of organotin compounds in water and seafood samples by online hyphenation of porous polymer-based magnetism-enhanced in-tube solid phase microextraction and HPLC.  ANALYTICA CHIMICA ACTA,      [PMID:35998999] [10.1016/j.aca.2022.340175]
11. Zhang Xiao-Hua, Ma Yi-Xin, Yi Chong, Qing Xiang-Dong, Liu Zhi, Zheng Jing-Jing, Lin Fang, Lv Tian-Feng.  (2020)  Chemometrics-enhanced HPLC–DAD as a rapid and interference-free strategy for simultaneous quantitative analysis of flavonoids in Chinese propolis.  EUROPEAN FOOD RESEARCH AND TECHNOLOGY,  246  (10): (1909-1918).  [PMID:] [10.1007/s00217-020-03543-7]
12. Wei Yang, Zhi-Kai Tian, Hui-Xin Yang, Zhao-Jun Feng, Jian-Mei Sun, Hong Jiang, Chao Cheng, Qing-Lei Ming, Chan-Min Liu.  (2019)  Fisetin improves lead-induced neuroinflammation, apoptosis and synaptic dysfunction in mice associated with the AMPK/SIRT1 and autophagy pathway.  FOOD AND CHEMICAL TOXICOLOGY,      [PMID:31539617] [10.1016/j.fct.2019.110824]
13. Chengyun He, Xiaoling Liu, Zhaojing Jiang, Sheng Geng, Hanjun Ma, Benguo Liu.  (2019)  Interaction Mechanism of Flavonoids and α-Glucosidase: Experimental and Molecular Modelling Studies.  Foods,  (9): (355).  [PMID:31438605] [10.3390/foods8090355]
14. Ni Zeng, Guowen Zhang, Xing Hu, Junhui Pan, Deming Gong.  (2019)  Mechanism of fisetin suppressing superoxide anion and xanthine oxidase activity.  Journal of Functional Foods,      [PMID:] [10.1016/j.jff.2019.04.044]
15. Yike Yue, Yongsheng Chen, Sheng Geng, Guizhao Liang, Benguo Liu.  (2018)  Antioxidant and α-Glucosidase Inhibitory Activities of Fisetin.  Natural Product Communications,      [PMID:] [10.1177/1934578X1801301119]
16. Hui Wang, Wenxi Zhang, Yatao Cheng, Xinyu Zhang, Nannan Xue, Gaorong Wu, Meng Chen, Kang Fang, Wenbo Guo, Fei Zhou, Herong Cui, Tao Ma, Penglong Wang, Haimin Lei.  (2018)  Design, Synthesis and Biological Evaluation of Ligustrazine-Flavonoid Derivatives as Potential Anti-Tumor Agents.  MOLECULES,  23  (9): (2187).  [PMID:30200208] [10.3390/molecules23092187]
17. Tingting Wang, Huajuan Lin, Qian Tu, Jingjing Liu, Xican Li.  (2016)  Fisetin Protects DNA Against Oxidative Damage and Its Possible Mechanism.  Advanced Pharmaceutical Bulletin,      [PMID:27478791] [10.15171/apb.2016.037]
18. Xiaodan Liu, Xia Wu.  (2014)  Fluorescence enhancement of fisetin by silver nanoparticles with cetyltrimethyl ammonium bromide micelles.  RSC Advances,  (10): (7433-7439).  [PMID:] [10.1039/C4RA12726A]
19. Zhenning Xu, Mo Wang, Tingting Zhou, Huanshun Yin, Shiyun Ai.  (2013)  Electrochemical biosensing method for the detection of DNA methylation and assay of the methyltransferase activity.  SENSORS AND ACTUATORS B-CHEMICAL,      [PMID:] [10.1016/j.snb.2012.12.124]
20. Huanshun Yin, Zhenning Xu, Mo Wang, Xueping Zhang, Shiyun Ai.  (2012)  An electrochemical biosensor for assay of DNA methyltransferase activity and screening of inhibitor.  ELECTROCHIMICA ACTA,      [PMID:] [10.1016/j.electacta.2012.11.093]
21. Huanshun Yin, Yunlei Zhou, Zhenning Xu, Lijian Chen, Di Zhang, Shiyun Ai.  (2012)  An electrochemical assay for DNA methylation, methyltransferase activity and inhibitor screening based on methyl binding domain protein.  BIOSENSORS & BIOELECTRONICS,      [PMID:23021851] [10.1016/j.bios.2012.09.010]
22. Shujuan Xu, Yong Shao, Kun Ma, Qinghua Cui, Guiying Liu, Fei Wu, Minjie Li.  (2011)  Fluorescence light-up recognition of DNA nucleotide based on selective abasic site binding of an excited-state intramolecular proton transfer probe.  ANALYST,  136  (21): (4480-4485).  [PMID:21946800] [10.1039/C1AN15652G]
23. Li-Feng Li, Meng-Di Wang, Chen-Yang Zhang, Meng-Yao Jin, Hua-Lei Chen, Huan Luo, Tian-Yu Hou, Zhi-Jun Zhang, He Li.  (2025)  Influence of hydroxyl substitution on the inhibition of flavonoids in advanced glycation end-products formation in glucose-lysine-arginine Maillard reaction models.  FOOD RESEARCH INTERNATIONAL,      [PMID:40086959] [10.1016/j.foodres.2025.116068]
24. Jiayi Zhang, Jingzhi Wang, Junfeng Wang, Weifeng Ni, Shichao Liu, Daqing Zhao, Zhengqi Dong, Shiting Yu, Siming Wang, Weinan Wang, Meichen Liu.  (2025)  Integrated multi-omics and machine learning reveal the intrinsic relationship between color and flavor variations in processed ginseng products through major pigment dynamics and non-enzymatic pathways.  LWT-FOOD SCIENCE AND TECHNOLOGY,      [PMID:] [10.1016/j.lwt.2025.118161]
25. Ziyi Yin, Yanli Dong, Zhi Li, Qianqian Wang, Qiuhua Wu.  (2025)  Constructing natural flavonoid based hyper crosslinked polymer combined to HPLC/MS for accurate determination of phenolic endocrine disruptors in chicken and fish meat.  Food Chemistry-X,      [PMID:40989098] [10.1016/j.fochx.2025.102983]
26. Ming Guan, Xiaojing Kang, Le Wei, Xingjun Hu, Chao Han, Xing Li, Hanwen Liu, Liang Qu, Zhenwen Zhao.  (2022)  A dual-mode strategy combining SERS with MALDI FTICR MS based on core-shell silver nanoparticles for dye identification and semi-quantification in unearthed silks from Tang Dynasty.  TALANTA,      [PMID:35121543] [10.1016/j.talanta.2022.123277]
27. Xiao-Man Ji, Xin-Xin Dong, Jia-Peng Li, Guang-Jie Tai, Shu Qiu, Wei Wei, Ceaser Wankumbu Silumbwe, Davaadagva Damdinjav, Joseph Nicolao Otieno, Xiao-Xue Li, Ming Xu.  (2025)  Fisetin Clears Senescent Cells Through the Pi3k-Akt-Bcl-2/Bcl-xl Pathway to Alleviate Diabetic Aortic Aging.  PHYTOTHERAPY RESEARCH,      [PMID:40259678] [10.1002/ptr.8507]
28. Haolin Zhang, Jingjing Zhang, Hui Cao, Petra Högger, Randolph Arroo, Mohamed A. Farag, Avi Shpigelman, Jianbo Xiao, Chunlin Li.  (2025)  Amination of Flavonoids Possessing a Pyrogallol Group in Cell Culture Medium at 37°C.  Food Frontiers,  (2): (1058-1078).  [PMID:] [10.1002/fft2.70002]
29. Maolin Chu, Suna Jiang, Jiawei Xue, Wenjing Li, Guanhua Jing, Hongying Li, Juan Zhang, Wanhai Xu.  (2025)  Premature renal epithelial cell senescence promoted by LXN/Rps3/p53 signaling pathway activation increases calcium oxalate crystal deposition by altering macrophage polarization.  Frontiers in Immunology,      [PMID:41112268] [10.3389/fimmu.2025.1658989]
30. Yongmei Chen, Qingwen Wei, Jing Wang, Chuanyao Huang, Zhenghao Wang, Yuchun Liu.  (2025)  Studies on the Flavonoid Composition of Pleioblastus amarus Leaves and Shoots Based on Targeted Metabolomics.  Metabolites,  15  (11): (709).  [PMID:41295295] [10.3390/metabo15110709]
31. Deng Yu, Jiang Xinyu, Che Zhenzhen, Shang Yaqi, Hu Mengting, Wang Wentian, Yu Weixian, Yang Bai, Liu Xinchan.  (2025)  Fisetin carbon dots alleviate periodontitis by enhancing mitophagy through regulation of sirtuin 3 SUMOylation.  JOURNAL OF NANOBIOTECHNOLOGY,      [PMID:41353553] [10.1186/s12951-025-03907-9]
32. Dahe Qiao, Chun Yang, Xiaozeng Mi, Sihui Liang, Yan Guo, Juan Chen, Zhengwu Chen.  (2026)  Comprehensive evaluation of tea processing quality characteristics in ‘Qiancha 1′ tea plant cultivar: chemical profiling across tea types from multi-grade raw materials.  Applied Food Research,  (1): (101723).  [PMID:] [10.1016/j.afres.2026.101723]
33. Changhai Sun, Mengxin Xiao, Biyue Cui, Shiyuan Sun, Shushuang Shen, Shuting Zhang, Xinran Zhang, Liting Mu.  (2026)  Study on the Correlation Between Anthoxanthins Compounds' Reverse-Phase Chromatographic Behavior and Their Solubility.  JOURNAL OF MOLECULAR STRUCTURE,      [PMID:] [10.1016/j.molstruc.2026.145944]
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