Fluocinolone Acetonide - Moligand™, 10mM in DMSO , Glucocorticoid receptor agonist, CAS No.67-73-2, Glucocorticoid receptor agonist

CAS: 67-73-2 Cat. No.: F407755 Molecular Weight: 452.49 EC Number: 200-668-5
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GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
Synonyms
Flucort-N | (6α,​11β,​16α)​-6,​9-​difluoro-​11,​21-​dihydroxy-​16,​17-​[(1-​methylethylidene)​bis(oxy)​]​-​pregna-​1,​4-​diene-​3,​20-​dione
Storage
Store at -80°C
Shipped In
Dry ice packs + Cold packs
 ·  off list, applied to all prices below.
Size
Status
Price
Qty
1ml
F407755-1ml
1
$60.90
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Why this grade

Moligand™, 10mM in DMSO Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 18 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

Information

Fluocinolone Acetonide Fluocinolone Acetonide (Flucort-N) is a corticosteroid that binds to the cytosolic glucocorticoid receptor.
In vitro


In vivo


Cell Data

cell lines:

Concentrations:

Incubation Time:

Powder Purity:≥99%

Specifications

Synonyms
Flucort-N | (6α, ​11β, ​16α)​-6, ​9-​difluoro-​11, ​21-​dihydroxy-​16, ​17-​[(1-​methylethylidene)​bis(oxy)​]​-​pregna-​1, ​4-​diene-​3, ​20-​dione
Specifications & Purity
Moligand™, 10mM in DMSO
Biochemical and Physiological Mechanisms
Fluocinolone Acetonide (Flucort-N) is a corticosteroid that binds to the cytosolic glucocorticoid receptor.
Storage
Store at -80°C
Shipped In
Dry ice packs + Cold packs
This product requires cold chain shipping. Ground and other economy services are not available.
Grade
Moligand™
Action Type
AGONIST
Mechanism of action
Glucocorticoid receptor agonist
Product Properties
ALogP2.5
Names and Identifiers
Isomeric SMILES C[C@]12C[C@@H]([C@]3([C@H]([C@@H]1C[C@@H]4[C@]2(OC(O4)(C)C)C(=O)CO)C[C@@H](C5=CC(=O)C=C[C@@]53C)F)F)O
WGK Germany 3
RTECS TU3830000
Molecular Weight 452.49
Reaxy-Rn 37811598
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=37811598&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Associated Targets(Human)
NR3C1 Tclin Glucocorticoid receptor (3 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Chemical and Physical Properties
Melt Point(°C)267-269°C
Documents & Articles
Citations of This Product
References
1. Yangjie LI, Jiaying HUANG, Jihui FANG, Zhiye HUANG.  (2022)  [Fast screening and confirmation of 73 common prohibited compounds in cosmetics by ultra performance liquid chromatography-quadrupole-time-of-flight high resolution mass spectrometry]..  Chinese Journal of Chromatography,  40  (5): (433-442).  [PMID:35478002] [10.3724/sp.j.1123.2021.09010]
2. Youfang Huang, Yanyun Li, Qing Luo, Xiaojia Huang.  (2020)  One-step preparation of functional groups-rich graphene oxide and carbon nanotubes nanocomposite for efficient magnetic solid phase extraction of glucocorticoids in environmental waters.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2020.126785]
3. Hua Li, Likun Zhao, Chaoqi Chen, Hua Zhu, Xuhui Mao.  (2025)  Immobilizing polycyclic aromatic hydrocarbon degrading bacteria with gel microspheres for bioaugmentation remediation of soil in a surfactant-enhanced slurry bioreactor.  Journal of Cleaner Production,      [PMID:] [10.1016/j.jclepro.2025.146653]
4. Zhe Zhao, Shumin Lin, Zhendong Yu, Ming Su, Bolong Liang, Shu-Xuan Liang, Xue-Hai Ju.  (2023)  Facile synthesis of triazine-based microporous organic network for high-efficient adsorption of flumequine and nadifloxacin: A comprehensive study on adsorption mechanisms and practical application potentials.  CHEMOSPHERE,      [PMID:36608878] [10.1016/j.chemosphere.2022.137731]
5. Xiaoxuan Zhou, Tao Liu, Shengyi Zhang, Bo Kang, Xu Duan, Yuanyuan Yan, Leiyu Feng, Yinguang Chen.  (2022)  Metagenomic insight of fluorene-boosted sludge acidogenic fermentation: Metabolic transformation of amino acids and monosaccharides.  SCIENCE OF THE TOTAL ENVIRONMENT,      [PMID:36587690] [10.1016/j.scitotenv.2022.161122]
6. Yue Cai, Binbin Yuan, Xiaoyue Ma, Guodong Fang, Dongmei Zhou, Juan Gao.  (2022)  Foliar application of SiO2 and ZnO nanoparticles affected polycyclic aromatic hydrocarbons uptake of Amaranth (Amaranthus tricolor L.): A metabolomics and typical statistical analysis.  SCIENCE OF THE TOTAL ENVIRONMENT,      [PMID:35429559] [10.1016/j.scitotenv.2022.155258]
7. Yingnan Liu, Wanqi Jiang, Zan Yang, Fei Tong, Lei Wang, Lu Zhu, Zhenyu Yu, Mingming Zheng, Yaqing Xiao, Yibin Zhou.  (2022)  Intelligent biogenic amine-responsive fluorescent label for visual and real-time monitoring of seafood freshness.  FOOD CHEMISTRY,      [PMID:35436636] [10.1016/j.foodchem.2022.132963]
8. Jiayang Zhang, Xiwen Ma, Xueping Dang, Huaixia Chen, Yuling Hu.  (2021)  Adsorption mechanism of polycyclic aromatic hydrocarbons on polythiophene-graphene covalent complex and its analytical application in food contact materials.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2021.106767]
9. Xiao-Yong Liao, Xue-Gang Gong, Li-Li Zhang, Daniel P. Cassidy.  (2021)  Micro-distribution of arsenic and polycyclic aromatic hydrocarbons and their interaction in Pteris vittata L..  ENVIRONMENTAL POLLUTION,      [PMID:33957513] [10.1016/j.envpol.2021.117250]
10. He-Tao Bian, Gao-Hua Wang, Jun-Jie Huang, Liang Liang, Ling Xiao, Hui-Ling Wang.  (2020)  Scutellarin protects against lipopolysaccharide-induced behavioral deficits by inhibiting neuroinflammation and microglia activation in rats.  INTERNATIONAL IMMUNOPHARMACOLOGY,      [PMID:33182053] [10.1016/j.intimp.2020.106943]
11. Yuan Hao, Yang Dezheng, Jia Zixian, Zhou Xiongfeng, Wang Hongli, Xu Qingnan, Wang Wenchun, Xu Yong.  (2020)  Activated Carbon Modified by Nanosecond Pulsed Discharge for Polycyclic Aromatic Hydrocarbons Detection.  PLASMA CHEMISTRY AND PLASMA PROCESSING,  40  (6): (1539-1553).  [PMID:] [10.1007/s11090-020-10114-x]
12. Wei Zhang, Peipei Zhou, Wei Liu, Huili Wang, Xuedong Wang.  (2020)  Enhanced adsorption/extraction of five typical polycyclic aromatic hydrocarbons from meat samples using magnetic effervescent tablets composed of dicationic ionic liquids and NiFe2O4 nanoparticles.  JOURNAL OF MOLECULAR LIQUIDS,      [PMID:] [10.1016/j.molliq.2020.113682]
13. Bian Hetao, Wang Gaohua, Huang Junjie, Liang Liang, Zheng Yage, Wei Yanyan, Wang Hui, Xiao Ling, Wang Huiling.  (2020)  Dihydrolipoic acid protects against lipopolysaccharide-induced behavioral deficits and neuroinflammation via regulation of Nrf2/HO-1/NLRP3 signaling in rat.  Journal of Neuroinflammation,  17  (1): (1-13).  [PMID:32450903] [10.1186/s12974-020-01836-y]
14. Zuotian Wu, Gaohua Wang, Huiling Wang, Ling Xiao, Yanyan Wei, Can Yang.  (2020)  Fluoxetine exposure for more than 2 days decreases the neuronal plasticity mediated by CRMP2 in differentiated PC12 cells.  BRAIN RESEARCH BULLETIN,      [PMID:32070769] [10.1016/j.brainresbull.2020.02.007]
15. Shutao Wang, Shiyu Liu, Xiange Che, Zhifang Wang, Jingkun Zhang, Deming Kong.  (2019)  Recognition of polycyclic aromatic hydrocarbons using fluorescence spectrometry combined with bird swarm algorithm optimization support vector machine.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,      [PMID:31374351] [10.1016/j.saa.2019.117404]
16. He Guo, Nan Jiang, Huijuan Wang, Kefeng Shang, Na Lu, Jie Li, Yan Wu.  (2019)  Enhanced catalytic performance of graphene-TiO2 nanocomposites for synergetic degradation of fluoroquinolone antibiotic in pulsed discharge plasma system.  APPLIED CATALYSIS B-ENVIRONMENTAL,      [PMID:] [10.1016/j.apcatb.2019.01.052]
17. Yan Kang, Huijun Xie, Bo Li, Jian Zhang, Huu Hao Ngo, Wenshan Guo, Zizhang Guo, Qiang Kong, Shuang Liang, Jie Liu, Tingting Cheng, Liwei Zhang.  (2018)  Performance of constructed wetlands and associated mechanisms of PAHs removal with mussels.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2018.09.152]
18. Xiaofei Liu, Xin Lu, Yong Huang, Chengwei Liu, Shulin Zhao.  (2013)  Fe3O4@ionic liquid@methyl orange nanoparticles as a novel nano-adsorbent for magnetic solid-phase extraction of polycyclic aromatic hydrocarbons in environmental water samples.  TALANTA,      [PMID:24401423] [10.1016/j.talanta.2013.11.039]
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