GLP-1R agonist 2 - ≥98% , CAS No.281209-71-0

CAS: 281209-71-0 Cat. No.: G646480 Molecular Weight: 348.25 EC Number: 803-650-0 PubChem CID: 16007289

GRADE & PURITY ≥98%

Synonyms

HY-121835 | GLP-1R agonist DMB | N-tert-butyl-6,7-dichloro-3-(methylsulfonyl)quinoxalin-2-amine | N-(tert-Butyl)-6,7-dichloro-3-(methylsulfonyl)quinoxalin-2-amine | GLP-1R agonist | SCHEMBL2555049 | GLP-1R agonist 2 | HMS3740K03 | GLP1-agonist-2 | E98852

Storage

Protected from light,Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

GLP-1R agonist 2 (compound 2) is a potent GLP-1R agonist. GLP-1R agonist 2 has the potential for the research of metabolic diseases like Type2 Diabetes and Obesity.

Form:Solid

Specifications

Synonyms

HY-121835 | GLP-1R agonist DMB | N-tert-butyl-6, 7-dichloro-3-(methylsulfonyl)quinoxalin-2-amine | N-(tert-Butyl)-6, 7-dichloro-3-(methylsulfonyl)quinoxalin-2-amine | GLP-1R agonist | SCHEMBL2555049 | GLP-1R agonist 2 | HMS3740K03 | GLP1-agonist-2 | E98852

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

GLP-1R agonist 2 (compound 2) is a potent GLP-1R agonist. GLP-1R agonist 2 has the potential for the research of metabolic diseases like Type2 Diabetes and Obesity.

Storage

Protected from light, Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

AGONIST

Purity

≥98%

Names and Identifiers

• Pubchem Sid: 528764608
• Canonical Smiles: CC(C)(C)NC1=NC2=CC(=C(C=C2N=C1S(=O)(=O)C)Cl)Cl
• IUPAC Name: N-tert-butyl-6,7-dichloro-3-methylsulfonylquinoxalin-2-amine
• InChIKey: GNZCSGYHILBXLL-UHFFFAOYSA-N
• INCHI: 1S/C13H15Cl2N3O2S/c1-13(2,3)18-11-12(21(4,19)20)17-10-6-8(15)7(14)5-9(10)16-11/h5-6H,1-4H3,(H,16,18)
• Isomeric SMILES: CC(C)(C)NC1=NC2=CC(=C(C=C2N=C1S(=O)(=O)C)Cl)Cl
• WGK Germany: 3
• PubChem CID: 16007289
• Molecular Weight: 348.25

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Class Diazanaphthalenes
      • Subclass Benzodiazines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Class: Diazanaphthalenes
• Subclass: Benzodiazines
• Intermediate Tree Nodes: Not available
• Direct Parent: Quinoxalines
• Alternative Parents: Aminopyrazines Imidolactams Benzenoids Aryl chlorides Sulfones Heteroaromatic compounds Azacyclic compounds Organochlorides Organic oxides Hydrocarbon derivatives Amines
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Quinoxaline - Aminopyrazine - Aryl chloride - Aryl halide - Pyrazine - Imidolactam - Benzenoid - Heteroaromatic compound - Sulfonyl - Sulfone - Azacycle - Hydrocarbon derivative - Organosulfur compound - Organonitrogen compound - Organochloride - Organohalogen compound - Organic oxide - Organic oxygen compound - Organic nitrogen compound - Amine - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as quinoxalines. These are compounds containing a quinoxaline moiety, a bicyclic heterocycle made up of a benzene ring fused to a pyrazine ring.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

GLP1R Tclin Glucagon-like peptide 1 receptor (2 Activities)

Discover Target: GLP1R

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GLP1R Tclin Glucagon-like peptide 1 receptor (111429 Activities)

Discover Target: GLP1R

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Solubility: DMSO : 25 mg/mL (71.79 mM; ultrasonic and warming and heat to 60°C)
• Sensitivity: Light sensitive
• Molecular Weight: 348.200 g/mol
• XLogP3: 3.900
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 347.026 Da
• Monoisotopic Mass: 347.026 Da
• Topological Polar Surface Area: 80.300 Ų
• Heavy Atom Count: 21
• Formal Charge: 0
• Complexity: 475.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

References

1. Xin Sun, Jiangnan Hu, Maomao Ren, Hong Chang, Dongting Zhangsun, Baojian Zhang, Shuai Dong.  (2024)  Stapling Cysteine[2,4] Disulfide Bond of α-Conotoxin LsIA and Its Potential in Target Delivery.  Marine Drugs,      [PMID:39057423] [10.3390/md22070314]

2. Jinnai Liu, Jiawei Tang, Hao Chen, Li Zhang, Ganlan Li, Fuli Zhang, Shaoxin Chen, Jun Yu.  (2026)  Highly Enantioselective Chemoenzymatic and Kilogram-Scale Process Development of (S)-3-Bromo-2-(1-methoxyethyl)pyridine.  ORGANIC PROCESS RESEARCH & DEVELOPMENT,      [PMID:] [10.1021/acs.oprd.5c00349]