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· · COA & SDS available for every product · Same-day shipping on in-stock items GNE-0946 - ≥98% , CAS No.1677667-24-1
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Ice chest + Ice pads
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Why this grade ≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
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Quality documents SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview GNE-0946 is a potent and selective RORγ( RORc) agonist with an EC 50 value of 4 nM for HEK-293 cell.
Form:Solid
Specifications Specifications & Purity
≥98%
Biochemical and Physiological Mechanisms
GNE-0946 is a potent and selective RORγ( RORc) agonist with an EC 50 value of 4 nM for HEK-293 cell.
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Names and Identifiers Canonical Smiles C1=CC2=C(N=C(N2C=C1)C(=O)C3=C(C=CC=C3Cl)C(F)(F)F)C4=CC(=C(C=C4)C(=O)O)O IUPAC Name 4-[3-[2-chloro-6-(trifluoromethyl)benzoyl]imidazo[1,5-a]pyridin-1-yl]-2-hydroxybenzoic acid InChIKey UAAUZNSONHHQQI-UHFFFAOYSA-N INCHI 1S/C22H12ClF3N2O4/c23-14-5-3-4-13(22(24,25)26)17(14)19(30)20-27-18(15-6-1-2-9-28(15)20)11-7-8-12(21(31)32)16(29)10-11/h1-10,29H,(H,31,32) Isomeric SMILES C1=CC2=C(N=C(N2C=C1)C(=O)C3=C(C=CC=C3Cl)C(F)(F)F)C4=CC(=C(C=C4)C(=O)O)O PubChem CID 91664317 Molecular Weight 460.79
Documentation 📋 Safety Data Sheet (SDS) Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS → ✅ Certificate of Analysis (COA) Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA → 📊 Datasheet Quick-reference summary of product specifications and applications.
View datasheet → 🔬 Specification Sheet Full quality attributes and acceptance criteria for this grade.
View spec sheet →
Advanced Data Taxonomic Classification Kingdom Organic compounds Superclass Organic oxygen compounds Class Organooxygen compounds Subclass Carbonyl compounds Intermediate Tree Nodes Ketones - Aryl ketones - Phenylketones Direct Parent Aryl-phenylketones Alternative Parents Phenylimidazoles Salicylic acids Trifluoromethylbenzenes Benzoic acids Imidazopyridines Benzoyl derivatives 1-hydroxy-2-unsubstituted benzenoids 1-hydroxy-4-unsubstituted benzenoids Chlorobenzenes Pyridines and derivatives Aryl chlorides N-substituted imidazoles Vinylogous halides Vinylogous acids Heteroaromatic compounds Azacyclic compounds Carboxylic acids Organic oxides Organonitrogen compounds Organochlorides Alkyl fluorides Hydrocarbon derivatives Organofluorides Molecular Framework Aromatic heteropolycyclic compounds Substituents Aryl-phenylketone - 5-phenylimidazole - 4-phenylimidazole - Hydroxybenzoic acid - Trifluoromethylbenzene - Salicylic acid or derivatives - Salicylic acid - Imidazopyridine - Benzoic acid - Benzoic acid or derivatives - Benzoyl - Phenol - 1-hydroxy-2-unsubstituted benzenoid - Chlorobenzene - Halobenzene - 1-hydroxy-4-unsubstituted benzenoid - Benzenoid - Monocyclic benzene moiety - Pyridine - Aryl halide - Aryl chloride - N-substituted imidazole - Vinylogous halide - Heteroaromatic compound - Azole - Imidazole - Vinylogous acid - Azacycle - Organoheterocyclic compound - Carboxylic acid derivative - Carboxylic acid - Organofluoride - Organonitrogen compound - Alkyl halide - Alkyl fluoride - Hydrocarbon derivative - Organic oxide - Organic nitrogen compound - Organochloride - Organohalogen compound - Aromatic heteropolycyclic compound Description This compound belongs to the class of organic compounds known as aryl-phenylketones. These are aromatic compounds containing a ketone substituted by one aryl group, and a phenyl group. External Descriptors Not available Data sources 1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
3D Structure Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Solubility DMSO : 100 mg/mL (217.02 mM; ultrasonic and warming and heat to 60°C) Molecular Weight 460.800 g/mol XLogP3 6.400 Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 8 Rotatable Bond Count 4 Exact Mass 460.044 Da Monoisotopic Mass 460.044 Da Topological Polar Surface Area 91.900 Ų Heavy Atom Count 32 Formal Charge 0 Complexity 724.000 Isotope Atom Count 0 Defined Atom Stereocenter Count 0 Undefined Atom Stereocenter Count 0 Defined Bond Stereocenter Count 0 Undefined Bond Stereocenter Count 0 The total count of all stereochemical bonds 0 Covalently-Bonded Unit Count 1
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