GNE 220 hydrochloride - ≥98% , CAS No.2448286-21-1

CAS: 2448286-21-1 Cat. No.: G651637 Molecular Weight: 474.99 PubChem CID: 134828260

GRADE & PURITY ≥98%

Storage

Store at 2-8°C,Desiccated

Shipped In

Wet ice

Overview

GNE 220 (hydrochloride) is a potent and selective inhibitor of MAP4K4 , with an IC 50 of 7 nM.

In Vitro

GNE-220 also inhibits a few other kinases with IC 50 s of 9 nM, 476 nM and 1.1 μM for MINK (MAP4K6), DMPK and KHS1 (MAP4K5), respectively. GNE-220 alters human umbilical vein endothelial cells (HUVEC) sprout morphology. GNE-220 also reduces pERM + retraction fibres in a dose-dependent manner. GNE-220 also dose-dependently increased the number of active-INTβ1 + long focal adhesions (FAs). MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:MAP4K4 7 nM (IC 50 ) MAP4K5 9 nM (IC 50 ) MAP4K6 1.1 μM (IC 50 ) DMPK 476 nM (IC 50 )

Specifications

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

GNE 220 (hydrochloride) is a potent and selective inhibitor of MAP4K4 , with an IC 50 of 7 nM.

Storage

Store at 2-8°C, Desiccated

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Purity

≥98%

Names and Identifiers

• Canonical Smiles: CC1=C2C(=NC(=N1)C3=CN(N=C3)C)C4=C(N2)N=CC(=C4)C5=CC=C(C=C5)N6CCN(CC6)C.Cl
• IUPAC Name: 6-methyl-12-[4-(4-methylpiperazin-1-yl)phenyl]-4-(1-methylpyrazol-4-yl)-3,5,8,10-tetrazatricyclo[7.4.0.02,7]trideca-1(9),2,4,6,10,12-hexaene;hydrochloride
• InChIKey: VBVBAEHNBOTZQV-UHFFFAOYSA-N
• INCHI: 1S/C25H26N8.ClH/c1-16-22-23(30-24(28-16)19-14-27-32(3)15-19)21-12-18(13-26-25(21)29-22)17-4-6-20(7-5-17)33-10-8-31(2)9-11-33;/h4-7,12-15H,8-11H2,1-3H3,(H,26,29);1H
• PubChem CID: 134828260
• Molecular Weight: 474.99

Chemical and Physical Properties

• Solubility: DMSO : 5.4 mg/mL (11.37 mM; Need ultrasonic) H2O : 5 mg/mL (10.53 mM; Need ultrasonic)