GRADE & PURITY 10mM in DMSO

Synonyms

Bibenzyl | rel-4,​4'-​[(1R,​2S)​-​1,​2-​diethyl-​1,​2-​ethanediyl]​bis-phenol

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Hexestrol (Bibenzyl) binds toERαandERβwithEC50of 0.07 nM and 0.175 nM, respectively.
In vitro

Hexestrol binds to ERα with EC50 of 0.07 nM and to ERβ with EC50 of 0.175 nM. Hexestrol inhibits activity of AKR1B13 with IC50 of 3.2 μM. Hexestrol inhibits the d-galactose dehydrogenase activity of thermophilus aldose 1-dehydrogenase with IC50 of 0.063 mM. Hexestrol inhibits the dehydrogenase activity of AKR1C20 towards 10 μM 4-androsten-3α-o1-17-one with IC50 values of 2.7 μM. Hexestrol inhibits 17HSD5 with IC50 of 30 μM, and inhibits TBER1 with IC50 of 0.8 μM. Hexestrol reacts with DNA through the catechol quinone, thus can be a carcinogen.

In vivo

Hexestrol administered intraperitoneally at dose of 6 mg/kg may decrease ovulation in mice, as evident by smaller ovaries and decreased luteal bodies and oocytes.
Cell Data

cell lines：Human T lymphoblastoid cells

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyms

Bibenzyl | rel-4, ​4'-​[(1R, ​2S)​-​1, ​2-​diethyl-​1, ​2-​ethanediyl]​bis-phenol

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Hexestrol (Bibenzyl) binds to ERα and ERβ with EC50 of 0.07 nM and 0.175 nM, respectively.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

• Isomeric SMILES: CC[C@H](C1=CC=C(C=C1)O)[C@@H](CC)C2=CC=C(C=C2)O
• UN Number: 2811
• Molecular Weight: 270.37
• Reaxy-Rn: 2056686
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2056686&ln=

Chemical and Physical Properties

• Solubility: Solubility (25°C) In vitro DMSO: 31 mg/mL (201.14 mM); Water: Insoluble; Ethanol: Insoluble
• Melt Point(°C): 185-188°C

References

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2. Sun Min, Wang Xiuqin, Ding Yali, Feng Juanjuan.  (2022)  Titania hybridized melamine–formaldehyde aerogel for online in-tube solid-phase microextraction of polycyclic aromatic hydrocarbons prior to HPLC–DAD.  MICROCHIMICA ACTA,  189  (12): (1-10).  [PMID:36416994] [10.1007/s00604-022-05572-3]

3. Yan Wu, Panpan Cao, Yanhao Jiang, Yanjuan Liu, Yuefei Zhang, Wei Chen, Zhengwu Bai, Sheng Tang.  (2022)  Ingenious introduction of aminopropylimidazole to tune the hydrophobic selectivity of dodecyl-bonded stationary phase for environmental organic pollutants.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2022.107933]

4. Yanqun Yang, Yipeng Huang, Zhuqiang Wu, Rui Shi, Zhengyi Chen, Guihua Ruan.  (2022)  Porous capillary monolithic column coupled with ultrahigh performance liquid chromatography-tandem mass spectrometry for fast and effective separation and determination of estrogens.  ANALYTICA CHIMICA ACTA,      [PMID:36089309] [10.1016/j.aca.2022.340270]

5. Jin Liu, Zhuoqun Su, Qinfeng Xu, Yiheng Shi, Di Wu, Lin Li, Yongning Wu, Guoliang Li.  (2022)  Facile synthesis of boric acid-functionalized magnetic covalent organic frameworks and application to magnetic solid-phase extraction of trace endocrine disrupting compounds from meat samples.  FOOD CHEMISTRY,      [PMID:35998488] [10.1016/j.foodchem.2022.133843]

6. Yuping Zhang, Ning Wang, Zhenyu Lu, Na Chen, Chengxing Cui, Xinxin Chen.  (2022)  Smart Titanium Wire Used for the Evaluation of Hydrophobic/Hydrophilic Interaction by In-Tube Solid Phase Microextraction.  MOLECULES,  27  (7): (2353).  [PMID:35408750] [10.3390/molecules27072353]

7. Jizhong Wu, Waqas Ahmad, Qin Ouyang, Jingui Zhang, Mingming Zhang, Quansheng Chen.  (2021)  Regenerative Flexible Upconversion-Luminescence Biosensor for Visual Detection of Diethylstilbestrol Based on Smartphone Imaging.  ANALYTICAL CHEMISTRY,      [PMID:34787394] [10.1021/acs.analchem.1c03325]

8. Mingxia Sun, Juanjuan Feng, Jiaqing Feng, Haili Sun, Yang Feng, Xiangping Ji, Chunying Li, Sen Han, Min Sun.  (2021)  Biochar nanosphere- and covalent organic framework nanosphere-functionalized titanium dioxide nanorod arrays on carbon fibers for solid-phase microextraction of organic pollutants.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2021.133645]

9. Xiaoxiao Zhu, Yijun Zhang, Pengfei Liu, Xiuzhi Bai, Na Chen, Yuping Zhang.  (2021)  Carbonized Aramid Fiber as the Adsorbent for In-Tube Solid-Phase Microextraction to Detect Estrogens in Water Samples.  Journal of Chemistry,      [PMID:] [10.1155/2021/9970518]

10. Wenqi Li, Jing Zhang, Wenli Zhu, Peige Qin, Qian Zhou, Minghua Lu, Xuebin Zhang, Wuduo Zhao, Shusheng Zhang, Zongwei Cai.  (2019)  Facile preparation of reduced graphene oxide/ZnFe2O4 nanocomposite as magnetic sorbents for enrichment of estrogens.  TALANTA,      [PMID:31816803] [10.1016/j.talanta.2019.120440]

11. Tianzhu Guan, Yonghai Sun, Yongjun Wang, Zhuolin Li, Tiezhu Li, Ligang Hou.  (2019)  Multi-Residue Method for the Analysis of Stilbene Estrogens in Milk.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,  20  (3): (744).  [PMID:30744198] [10.3390/ijms20030744]

12. Lei Chen, Mingyue Zhang, Fengfu Fu, Jingguang Li, Zian Lin.  (2018)  Facile synthesis of magnetic covalent organic framework nanobeads and application to magnetic solid-phase extraction of trace estrogens from human urine.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:30100013] [10.1016/j.chroma.2018.06.066]

13. Xuemin Chen, Yanhui Ma, Danchao Chen, Ming Ma, Chunya Li.  (2015)  Electrochemical fabrication of polymerized imidazole-based ionic liquid bearing pyrrole moiety for sensitive determination of hexestrol in chicken meat.  FOOD CHEMISTRY,      [PMID:25766811] [10.1016/j.foodchem.2015.02.038]

14. Jun Ding, Qiang Gao, Xiao-Shui Li, Wei Huang, Zhi-Guo Shi, Yu-Qi Feng.  (2011)  Magnetic solid-phase extraction based on magnetic carbon nanotube for the determination of estrogens in milk.  JOURNAL OF SEPARATION SCIENCE,  34  (18): (2498-2504).  [PMID:21780288] [10.1002/jssc.201100323]

15. Qiong-Wei Yu, Qiao Ma, Yu-Qi Feng.  (2011)  Temperature-response polymer coating for in-tube solid-phase microextraction coupled to high-performance liquid chromatography.  TALANTA,      [PMID:21530774] [10.1016/j.talanta.2011.03.003]

16. Jiaqi Xu, Wenrui Li, Min Sun, Qianyu Li, Fan Jiang, Yongning Wu, Guoliang Li.  (2025)  Magnetic cationic covalent organic framework for efficient enrichment and detection of phenolic endocrine disruptors in foodstuffs.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:40073640] [10.1016/j.chroma.2025.465827]

17. Wenjing Wang, Fei Zhai, Fupei Xu, Min Jia.  (2022)  Enzyme-free amplified and one-step rapid detection of bisphenol A using dual-terminal labeled split aptamer probes.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2022.107977]

18. Xian Liu, Like Chen, Yang Yang, Liping Xu, Junyong Sun, Tian Gan.  (2022)  MXene−reinforced octahedral PtCu nanocages with boosted electrocatalytic performance towards endocrine disrupting pollutants sensing.  JOURNAL OF HAZARDOUS MATERIALS,      [PMID:36137886] [10.1016/j.jhazmat.2022.130000]

19. Zhang Qianchun, Wang Yutong, Yang Bingnian, Bao Linchun, Wu Yun, Wang Xingyi.  (2022)  Development of an Efficient Solid-Phase Microextraction Monolithic Column for the Analysis of Estrogens in Human Urine and Serum Samples.  CHROMATOGRAPHIA,  85  (8): (733-741).  [PMID:] [10.1007/s10337-022-04178-4]

20. Tiemei Li, Xin Zhang, Lichong Duan, Shuhao Cui, Yingyu Chang, Xia Zhang.  (2025)  A novel ferrofluid based on hydrophobic deep eutectic solvent and Fe3O4@NH2-graphene oxide for the analysis of estrogens from various samples.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2025.115019]