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HIF-1α-IN-2 , CAS No.2762315-06-8
AVAILABLE TO ORDER
Storage
Store at 2-8°C,Protected from light,Desiccated
Shipped In
Wet ice
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Why this grade
for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Storage & shipping
Store at 2-8°C,Protected from light,Desiccated Ships Wet ice Check lot-specific COA for exact specifications.
Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
HIF-1α-IN-2 is an effective HIF-1α inhibitor with anticancer potencies ( IC 50 s of 28 nM and 15 nM in MDA-MB-231 and MiaPaCa-2 cells, respectively). HIF-1α-IN-2 suppresses HIF-1α expression by blocking transcription and protein translation
In Vitro
HIF-1α-IN-2 (compound 7f) (5 μM; 72h) suppresses the viability of MDA-MB-231 and MiaPaCa-2 cells with IC 50 s of 28 nM and 15 nM, respectively. HIF-1α-IN-2 (0-1 μM; 72h) suppresses the expression of HIF-1α and VEGF with dose-dependent effect. HIF-1α-IN-2 (0.25, 0.5, and 1 µM; 16-24h) can significantly inhibit the migration of MDA-MD-231 cells by 56% (0.25 µM), 83% (0.5 µM), and 85% (1 µM), respectively, and also noted in MiaPaCa-2 cells, which demonstrates the unique anti-migration effect of HIF-1α-IN-2. HIF-1α-IN-2 (0-1 μM; 72h) suppresses HIF-1α mRNA levels in MDA-MB-231 cells under hypoxia. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability Assay Cell Line: MDA-MB-231 cells, MiaPaCa-2 cellsConcentration: 5 μM Incubation Time: 72 hours Result: Suppressed the viability of these two cell lines with IC 50 of 28 nM and 15 nM in MDA-MB-231 and MiaPaCa-2 cells, respectively. Cell Viability Assay Cell Line: MDA-MB-231 cells, MiaPaCa-2 cellsConcentration: 5 μM Incubation Time: 72 hours Result: Suppressed the viability of these two cell lines with IC 50 of 28 nM and 15 nM in MDA-MB-231 and MiaPaCa-2 cells, respectively.
Form:Solid
IC50& Target:IC 50 : 28 nM (HIF-1α) in MDA-MB-231, 15 nM (HIF-1α) in MiaPaCa-2
Specifications
Biochemical and Physiological Mechanisms
HIF-1α-IN-2 is an effective HIF-1α inhibitor with anticancer potencies ( IC 50 s of 28 nM and 15 nM in MDA-MB-231 and MiaPaCa-2 cells, respectively). HIF-1α-IN-2xa0suppresses HIF-1α expression by blocking transcription andxa0protein translation.
Storage
Store at 2-8°C, Protected from light, Desiccated
Shipped In
Wet ice
This product requires cold chain shipping. Ground and other economy services are not available.
Action Type
INHIBITOR
Names and Identifiers
| Molecular Weight | 361.46 |
|---|
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →✅ Certificate of Analysis (COA)
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Look up COA →🔬 Specification Sheet
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Certificates（CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
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Chemical and Physical Properties
| Solubility | DMSO : 100 mg/mL (276.66 mM; Need ultrasonic) |
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