hSMG-1 inhibitor 11e - 10mM in DMSO , CAS No.1402452-10-1

CAS: 1402452-10-1 Cat. No.: H656478 Molecular Weight: 517.60 PubChem CID: 71458574

GRADE & PURITY 10mM in DMSO

Storage

Protected from light,Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

hSMG-1 inhibitor 11e is a potent and selective hSMG-1 kinase inhibitor with an IC 50 of <0.05 nM. hSMG-1 inhibitor 11e shows >900-fold selectivity over mTOR (IC 50 of 45 nM), PI3Kα/γ (IC 50 s of 61 nM and 92 nM) and CDK1/CDK2 (IC 50 s of 32 μM and 7.1 μM)

In Vitro

hSMG-1 kinase plays a dual role in a highly conserved RNA surveillance pathway termed nonsense-mediated RNA decay (NMD) and in cellular genotoxic stress response. Since deregulation of cellular responses to stress contributes to tumor growth and resistance to chemotherapy, hSMG-1 is a potential target for cancer treatment. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:hSMG-1 <0.05 nM (IC 50 ) mTOR 45 nM (IC 50 ) PI3Kα 61 nM (IC 50 ) PI3Kγ 92 nM (IC 50 ) CDK1 32 μM (IC 50 ) CDK2 7.1 μM (IC 50 )

Specifications

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

hSMG-1 inhibitor 11e is a potent and selective hSMG-1 kinase inhibitor with an IC 50 of <0.05 nM. hSMG-1 inhibitor 11e shows >900-fold selectivity over mTOR (IC 50 of 45 nM), PI3Kα/γ (IC 50 s of 61 nM and 92 nM) and CDK1/CDK2 (IC 50 s of 32 μM and 7.1 μM)

Storage

Protected from light, Desiccated, Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

• Isomeric SMILES: CC1=C(C=C(C=C1)NC2=NC=CC(=N2)C3=CC(=NC=C3)C4=CC=C(C=C4)NC(=O)NC)S(=O)(=O)N(C)C
• PubChem CID: 71458574
• Molecular Weight: 517.60