Hydroxytyrosol - ≥95% , CAS No.10597-60-1

CAS: 10597-60-1 Cat. No.: H306005 Molecular Weight: 154.16 Beilstein Registry Number: 2208118 EC Number: 600-704-3
AVAILABLE TO ORDER
GRADE & PURITY ≥95%
Synonyms
dopet | HY-N0570 | AM20020163 | HYDROXYTYROSOL [INCI] | (1)Benzothieno(2,3-d)pyrimidin-4(1H)-one, 5,6,7,8-tetrahydro-2-methyl- | 3,4-dihydroxy-1-benzeneethanol | 4-(2-Hydroxy-ethyl)-benzene-1,2-diol | 4-(2-hydroxyethyl)benzene-1,2-diol | NSC-758468 | QEU0
Storage
Store at 2-8°C,Argon charged
Shipped In
Wet ice
 ·  off list, applied to all prices below.
Size
Status
Price
Qty
250mg
H306005-250mg
2
$15.90
1g
H306005-1g
2
$25.90
5g
H306005-5g
2
$32.90
Enter a quantity for the sizes you want to add.
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Why this grade

≥95% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Store at 2-8°C,Argon charged Ships Wet ice Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 26 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Specifications

Synonyms
dopet | HY-N0570 | AM20020163 | HYDROXYTYROSOL [INCI] | (1)Benzothieno(2, 3-d)pyrimidin-4(1H)-one, 5, 6, 7, 8-tetrahydro-2-methyl- | 3, 4-dihydroxy-1-benzeneethanol | 4-(2-Hydroxy-ethyl)-benzene-1, 2-diol | 4-(2-hydroxyethyl)benzene-1, 2-diol | NSC-758468 | QEU0
Specifications & Purity
≥95%
Storage
Store at 2-8°C, Argon charged
Shipped In
Wet ice
This product requires cold chain shipping. Ground and other economy services are not available.
Purity
≥95%
Names and Identifiers
Pubchem Sid504755628
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/504755628
Canonical SmilesC1=CC(=C(C=C1CCO)O)O
IUPAC Name4-(2-hydroxyethyl)benzene-1,2-diol
InChIKeyJUUBCHWRXWPFFH-UHFFFAOYSA-N
INCHI1S/C8H10O3/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,9-11H,3-4H2
Isomeric SMILES C1=CC(=C(C=C1CCO)O)O
WGK Germany 3
Molecular Weight 154.16
Beilstein 2208118
Reaxy-Rn 2208118
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2208118&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassBenzenoids
ClassPhenols
SubclassTyrosols and derivatives
Intermediate Tree Nodes Not available
Direct ParentTyrosols
Alternative Parents Catechols  1-hydroxy-4-unsubstituted benzenoids  1-hydroxy-2-unsubstituted benzenoids  Benzene and substituted derivatives  Primary alcohols  Hydrocarbon derivatives  
Molecular FrameworkAromatic homomonocyclic compounds
Substituents Tyrosol - Catechol - 1-hydroxy-4-unsubstituted benzenoid - 1-hydroxy-2-unsubstituted benzenoid - Monocyclic benzene moiety - Organic oxygen compound - Hydrocarbon derivative - Primary alcohol - Organooxygen compound - Alcohol - Aromatic homomonocyclic compound
DescriptionThis compound belongs to the class of organic compounds known as tyrosols. These are organic aromatic compounds containing a phenethyl alcohol moiety that carries a hydroxyl group at the 4-position of the benzene group.
External Descriptors catechols - primary alcohol
3D Structure
Interactive Chemical Structure Model





Associated Targets(Human)
ALOX5 Tclin Arachidonate 5-lipoxygenase (6568 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BACE1 Tchem Beta-secretase 1 (15641 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HT-29 (80576 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PANC-1 (6144 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PC-3 (62116 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SH-SY5Y (11521 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SK-BR-3 (5175 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SW480 (6023 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HeLa (62764 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DG-75 (165 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Associated Targets(non-human)
NA Neuraminidase (1107 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Pseudomonas aeruginosa (123386 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Staphylococcus aureus (210822 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Escherichia coli (133304 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Aspergillus niger (16508 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Bacillus subtilis (32866 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Candida albicans (78123 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Salmonella enterica (1497 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MDCK (10148 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mechanisms of Action
Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

12 results found

Lot NumberCertificate TypeDateItem
G2215538Certificate of AnalysisApr 07, 2026 H306005
G2215539Certificate of AnalysisApr 07, 2026 H306005
I2308158Certificate of AnalysisAug 30, 2023 H306005
I2308159Certificate of AnalysisAug 30, 2023 H306005
I2306498Certificate of AnalysisAug 29, 2023 H306005
I2306499Certificate of AnalysisAug 29, 2023 H306005
I2306500Certificate of AnalysisAug 29, 2023 H306005
I2306501Certificate of AnalysisAug 29, 2023 H306005
I2306502Certificate of AnalysisAug 29, 2023 H306005
I2306503Certificate of AnalysisAug 29, 2023 H306005
G2215540Certificate of AnalysisJul 01, 2022 H306005
I2306191Certificate of AnalysisJul 01, 2022 H306005

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Chemical and Physical Properties
Refractive Index1.58
Molecular Weight154.160 g/mol
XLogP3-0.700
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count3
Rotatable Bond Count2
Exact Mass154.063 Da
Monoisotopic Mass154.063 Da
Topological Polar Surface Area60.700 Ų
Heavy Atom Count11
Formal Charge0
Complexity116.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Citations of This Product
References
1. Shuyan Han, Hongmei Hou, Yiren Zhang, Zhongxiang Fang, Yun Li, Le Zhang, Yandan Wang, Shijia Zhang, Hui Zhang, Qingzhe Jin, Gangcheng Wu, Xingguo Wang.  (2023)  Oleuropein and its hydrolysate from extra virgin olive oil inhibit breast cancer cells proliferation interfering with the PI3K-AKT signal pathway.  Journal of Functional Foods,      [PMID:] [10.1016/j.jff.2023.105880]
2. Chenchen Zhao, Yu Sha, Wei Zhuang, Yuan Rao, Jihang Zhang, Jinglan Wu, Tao Shen, Zhuotao Tan, Chenjie Zhu, Hongman Zhang, Hanjie Ying.  (2023)  Production of hydroxytyrosol from tyrosol via controllable oxidation with immobilized tyrosinase: A comparative study.  PROCESS BIOCHEMISTRY,      [PMID:] [10.1016/j.procbio.2023.06.017]
3. Fengxia Tang, Chuan Li, Xiaoran Yang, Jiandu Lei, Hongxia Chen, Changwei Zhang, Chengzhang Wang.  (2022)  Effect of Variety and Maturity Index on the Physicochemical Parameters Related to Virgin Olive Oil from Wudu (China).  Foods,  12  (1): (7).  [PMID:36613224] [10.3390/foods12010007]
4. Fan Wu, Fulin Tian, Zhou Jin, Jing Liu, Weiping Jin, Xuan Chen, Zhan Wang, Xiwu Jia, Benguo Liu, Lingyi Liu, Wangyang Shen.  (2021)  Antioxidant capacities of heat-treated wheat germ and extruded compounded bran.  CEREAL CHEMISTRY,  99  (3): (582-592).  [PMID:] [10.1002/cche.10520]
5. Xiaorong Zhang, Yun Jiang, Jiajie Mao, Xuekun Ren, Yinghui Ji, Yixin Mao, Yang Chen, Xiaoyu Sun, Yihuai Pan, Jianfeng Ma, Shengbin Huang.  (2021)  Hydroxytyrosol prevents periodontitis-induced bone loss by regulating mitochondrial function and mitogen-activated protein kinase signaling of bone cells.  FREE RADICAL BIOLOGY AND MEDICINE,      [PMID:34610362] [10.1016/j.freeradbiomed.2021.09.027]
6. Mingtao Zhao, Xulin Hong, Abdullah, Ruilian Yao, Yi Xiao.  (2020)  Rapid biosynthesis of phenolic glycosides and their derivatives from biomass-derived hydroxycinnamates.  GREEN CHEMISTRY,  23  (2): (838-847).  [PMID:] [10.1039/D0GC03595E]
7. Yang Li, Ying Peng, Ping Ma, Mengyue Wang, Chongsheng Peng, Pengfei Tu, Xiaobo Li.  (2019)  In vitro and in vivo metabolism of Cistanche tubulosa extract in normal and chronic unpredictable stress-induced depressive rats.  JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,      [PMID:31352203] [10.1016/j.jchromb.2019.121728]
8. Jiahong Han, Min Dai, Yan Zhao, Enbo Cai, Lianxue Zhang, Xiaohuan Jia, Nian Sun, Xuan Fei, Hui Shu.  (2019)  Compatibility effects of ginseng and Ligustrum lucidum Ait herb pair on hematopoietic recovery in mice with cyclophosphamide-induced myelosuppression and its material basis.  Journal of Ginseng Research,      [PMID:32148411] [10.1016/j.jgr.2019.01.001]
9. Hao QIAN, Fang-Jun YU, Dan-Yi LU, Bao-Jian WU, Xing-Wang ZHANG, Huan WANG, Zhi-Guo MA.  (2018)  Identification of poliumoside metabolites in rat plasma, urine, bile, and intestinal bacteria with UPLC/Q-TOF-MS.  Chinese Journal of Natural Medicines,      [PMID:30502769] [10.1016/S1875-5364(18)30129-8]
10. Li-xing Wu, Yu-yu Xu, Zhi-jian Yang, Qing Feng.  (2018)  Hydroxytyrosol and olive leaf extract exert cardioprotective effects by inhibiting GRP78 and CHOP expression.  Journal of Biomedical Research,      [PMID:29760296] [10.7555/JBR.32.20170111]
11. Lingyi Liu, Zhou Jin, Min Wang, Wangyang Shen, Zhenzhou Zhu, Zhan Wang, Lianliang Liu.  (2018)  W/O Nano-Emulsions with Olive Leaf Phenolics Improved Oxidative Stability of Sacha Inchi Oil.  EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY,  120  (5): (1700471).  [PMID:] [10.1002/ejlt.201700471]
12. Zhihong Wang, Chengzhang Wang, Changwei Zhang, Wenjun Li.  (2017)  Ultrasound-assisted enzyme catalyzed hydrolysis of olive waste and recovery of antioxidant phenolic compounds.  Innovative Food Science & Emerging Technologies,      [PMID:] [10.1016/j.ifset.2017.02.013]
13. Yang Li, Guisheng Zhou, Ying Peng, Pengfei Tu, Xiaobo Li.  (2015)  Screening and identification of three typical phenylethanoid glycosides metabolites from Cistanches Herba by human intestinal bacteria using UPLC/Q-TOF-MS.  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,      [PMID:26551535] [10.1016/j.jpba.2015.10.038]
14. Shiming Tang, Zhilin Ouyang, Ying Huo, Daocheng Liao, Zhiteng Zhang, Ying Lin, Suiping Zheng.  (2024)  An engineered dual-functional L-DOPA decarboxylase enables a minimized hydroxytyrosol cascade.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:39615727] [10.1016/j.ijbiomac.2024.138176]
15. Meiyu Gu, Jiahui Shi, Boya Zhang, Xibo Wang, Xu Wang.  (2024)  Covalent modification of soy protein isolates by hydroxytyrosol: Effects on structural and functional properties of adducts.  LWT-FOOD SCIENCE AND TECHNOLOGY,      [PMID:] [10.1016/j.lwt.2024.116041]
16. Tian Xia, Xiao-jiang Mao, Jian Zhang, Samad Rahimnejad, Kang-le Lu.  (2024)  Effects of quercetin and hydroxytyrosol supplementation in a high-fat diet on growth, lipid metabolism, and mitochondrial function in spotted seabass (Lateolabrax maculatus).  AQUACULTURE,      [PMID:] [10.1016/j.aquaculture.2023.740538]
17. Wen-Kai Liu, Xiu-Xin Ren, Lian Xu, Juan Lin.  (2025)  Modular cascade with engineered HpaB for efficient synthesis of hydroxytyrosol.  BIOORGANIC CHEMISTRY,      [PMID:39764921] [10.1016/j.bioorg.2025.108125]
18. Wen-Kai Liu, Bing-Mei Su, Xin-Qi Xu, Lian Xu, Juan Lin.  (2024)  Multienzymatic Cascade for Synthesis of Hydroxytyrosol via Two-Stage Biocatalysis.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,      [PMID:38940657] [10.1021/acs.jafc.4c04228]
19. Yi Wang, Ruge Lin, Laiming Zhang, Suqing Lan, Xingqian Ye, Haibo Pan, Shiguo Chen.  (2024)  Oxygen influences in vitro assessment for phenolic compounds: Digestive stability, α-glucosidase inhibitory activity and bioavailability.  FOOD CHEMISTRY,      [PMID:39608122] [10.1016/j.foodchem.2024.142165]
20. Yang Li, Guisheng Zhou, Shihua Xing, Pengfei Tu, Xiaobo Li.  (2015)  Identification of Echinacoside Metabolites Produced by Human Intestinal Bacteria Using Ultraperformance Liquid Chromatography–Quadrupole Time-of-Flight Mass Spectrometry.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,      [PMID:26186273] [10.1021/acs.jafc.5b02881]
21. Yang Li, Ying Peng, Mengyue Wang, Guisheng Zhou, Yulong Zhang, Xiaobo Li.  (2016)  Rapid screening and identification of the differences between metabolites of Cistanche deserticola and C. tubulosa water extract in rats by UPLC-Q-TOF-MS combined pattern recognition analysis.  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,      [PMID:27639339] [10.1016/j.jpba.2016.09.018]
22. Yang Li, Ying Peng, Mengyue Wang, Pengfei Tu, Xiaobo Li.  (2017)  Human Gastrointestinal Metabolism of the Cistanches Herba Water Extract in Vitro: Elucidation of the Metabolic Profile Based on Comprehensive Metabolite Identification in Gastric Juice, Intestinal Juice, Human Intestinal Bacteria, and Intestinal Microsomes.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,      [PMID:28771352] [10.1021/acs.jafc.7b02829]
23. Hongyu Zhang, Guoshun Lin, Yang Yang, Yifei Wang, Xiushuo Yang, Guige Hou, Zhenbo Wang, Qingguo Meng, Yun Hou.  (2025)  Hydroxytyrosol Inhibits BPS-Induced NF-κB Signaling Pathway Activation, Mitigates Oxidative Stress, and Reduces Neuronal Apoptosis.  JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY,  39  (6): (e70303).  [PMID:40384030] [10.1002/jbt.70303]
24. Defan Zeng, Wenfeng Peng, Yupan Li, Fuquan Zhang, Xiaoxue Liao, Lusheng Liao.  (2025)  Effect of High-Efficiency Antioxidant on Storage Stability of Constant-Viscosity Natural Rubber.  POLYMER ENGINEERING AND SCIENCE,      [PMID:] [10.1002/pen.70220]
25. Hongyu Zhang, Guoshun Lin, Yifei Wang, Aihui Zheng, Hanlin Luo, Zhang Cao, Guige Hou, Yun Hou.  (2025)  Therapeutic potential of hydroxytyrosol against bisphenol S-induced toxicity to microglia via targeting cytochrome P450 1A1 (CYP1A1).  PHYTOMEDICINE,      [PMID:41330185] [10.1016/j.phymed.2025.157629]
26. Sitong Wu, Shiyao Li, Binglan Jia, Songge Cai, Qiang Cui, Xibo Wang, Xu Wang.  (2026)  Modulating dynamic interactions between soy protein isolate and hydroxytyrosol via pH-driven technology: Binding mechanism, structure, and functional characteristics.  LWT-FOOD SCIENCE AND TECHNOLOGY,      [PMID:] [10.1016/j.lwt.2026.119286]
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