10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
I-OMe-Tyrphostin AG 538 (I-OMe-AG 538) is a specific inhibitor of IGF-1R (insulin-like growth factor-1 receptor tyrosine kinase). I-OMe-Tyrphostin AG 538 inhibits IGF-1R-mediated signaling and is preferentially cytotoxic to nutrient-deprived PANC1 cells. I-OMe-Tyrphostin AG 538 is an ATP-competitive inhibitor of phosphatidylinositol-5-phosphate 4-kinase α (PI5P4Kα) , with an IC 50 of 1 µM
In Vitro
I-OMe-Tyrphostin AG 538 (I-OMe-AG 538) (0.1-1000 µM; 24 hours) is cytotoxic to PANC-1 cells in nutrient-deprived medium. I-OMe-Tyrphostin AG 538 (0-3 µM; 1 hour) blocks phosphorylation of IGF-1R, Akt and Erk. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: PANC-1 cells Concentration: 0.1, 1, 10, 1000 µM Incubation Time: 24 hours Result: Cytotoxic to PANC-1 cells in nutrient-deprived medium. Western Blot AnalysisCell Line: PANC-1 cells (stimulation with 50 ng/ml IGF-1 for 10 min) Concentration: 0.03, 0.3, 3 µM Incubation Time: 1 hour Result: Blocked phosphorylation of IGF-1R, Akt and Erk.
IC50& Target:IC50: 1 µM (PI5P4Kα)
| Isomeric SMILES | COC1=C(C(=CC(=C1)/C=C(\C#N)/C(=O)C2=CC(=C(C=C2)O)O)I)O |
|---|---|
| Alternate CAS | 1094048-77-7 |
| PubChem CID | 5353685 |
| Molecular Weight | 437.19 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
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View spec sheet →| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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